LMPD Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
LMP012760

UniProt Annotations

Entry Information
Gene Namedihydrolipoamide S-acetyltransferase
Protein EntryODP2_RAT
UniProt IDP08461
SpeciesRat
Comments
Comment typeDescription
Catalytic ActivityAcetyl-CoA + enzyme N(6)-(dihydrolipoyl)lysine = CoA + enzyme N(6)-(S-acetyldihydrolipoyl)lysine.
CofactorName=(R)-lipoate; Xref=ChEBI:CHEBI:83088; Note=Binds 1 lipoyl cofactor covalently.;
DiseaseNote=Primary biliary cirrhosis (PBC) is an autoimmune disease characterized by inflammatory obliteration of intra- hepatic bile duct, leading to liver cell damage and cirrhosis. The E2 component of pyruvate dehydrogenase complex is the autoantigen for PBC.
FunctionThe pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle.
SimilarityBelongs to the 2-oxoacid dehydrogenase family
SimilarityContains 2 lipoyl-binding domains
Subcellular LocationMitochondrion matrix.
SubunitPart of the multimeric pyruvate dehydrogenase complex that contains multiple copies of pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (DLAT, E2) and lipoamide dehydrogenase (DLD, E3). These subunits are bound to an inner core composed of about 48 DLAT and 12 PDHX molecules. Interacts with PDK2 and PDK3 (By similarity)
Tissue SpecificityExpressed in flagella of epididymal sperm