LMPD Database

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LMP012844

UniProt Annotations

Entry Information
Gene Namecarboxylesterase 1D
Protein EntryCES1D_RAT
UniProt IDP16303
SpeciesRat
Comments
Comment typeDescription
Biophysicochemical PropertiesKinetic parameters: KM=0.71 M for oleic acid ; Vmax=1482 nmol/h/mg enzyme toward oleic acid ; pH dependence: Optimum pH for FAEE synthesis is 7.0. Optimum pH for PNPB- hydrolyzing activity is 6-8. ;
Catalytic ActivityA carboxylic ester + H(2)O = an alcohol + a carboxylate. {ECO:0000255|PROSITE-ProRule:PRU10039, ECO:0000269|PubMed:1429692}.
Catalytic ActivityA long-chain-fatty-acyl ethyl ester + H(2)O = a long-chain-fatty acid + ethanol
Enzyme RegulationFAEE-synthesizing and PNPB-hydrolyzing activities are both inhibited by DFP
FunctionMajor lipase in white adipose tissue (By similarity). Involved in the metabolism of xenobiotics and of natural substrates. Hydrolyzes triacylglycerols and monoacylglycerols, with a preference for monoacylglycerols. The susceptibility of the substrate increases with decreasing acyl chain length of the fatty acid moiety. Catalyzes the synthesis of fatty acid ethyl esters
SimilarityBelongs to the type-B carboxylesterase/lipase family
Subcellular LocationEndoplasmic reticulum lumen. Cytoplasm, cytosol {ECO:0000250}. Lipid droplet .
SubunitHomotrimer
Tissue SpecificityDetected in liver, lung and testis, but not in kidney (at protein level)