LMPD Database

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LMP012915

UniProt Annotations

Entry Information
Gene Namesuccinate dehydrogenase complex, subunit A, flavoprotein (Fp)
Protein EntrySDHA_RAT
UniProt IDQ920L2
SpeciesRat
Comments
Comment typeDescription
Catalytic ActivitySuccinate + a quinone = fumarate + a quinol.
CofactorName=FAD; Xref=ChEBI:CHEBI:57692; Evidence= ;
FunctionFlavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). Can act as a tumor suppressor
PathwayCarbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1.
PtmDeacetylated by SIRT3
PtmPhosphorylation at Tyr-207 is important for efficient electron transfer in complex II and the prevention of ROS generation
SimilarityBelongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily
Subcellular LocationMitochondrion inner membrane ; Peripheral membrane protein ; Matrix side .
SubunitComponent of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD. Interacts with SDHAF2/SDH5; interaction is required for FAD attachment (By similarity). Interacts with TRAP1 (By similarity)