LMPD Database

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LMP012926

UniProt Annotations

Entry Information
Gene Namezinc finger, DHHC-type containing 7
Protein EntryZDHC7_RAT
UniProt IDQ923G5
SpeciesRat
Comments
Comment typeDescription
Catalytic ActivityPalmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.
DomainThe DHHC domain is required for palmitoyltransferase activity
FunctionPalmitoyltransferase with broad specificity. Palmitoylates SNAP25 and DLG4/PSD95. May palmitoylate GABA receptors on their gamma subunit (GABRG1, GABRG2 and GABRG3) and thereby regulate their synaptic clustering and/or cell surface stability (By similarity). Palmitoylates sex steroid hormone receptors, including ESR1, PGR and AR, thereby regulating their targeting to the plasma membrane. This affects rapid intracellular signaling by sex hormones via ERK and AKT kinases and the generation of cAMP, but does not affect that mediated by their nuclear receptors (By similarity). May play a role in follicle stimulation hormone (FSH) activation of testicular Sertoli cells
SimilarityBelongs to the DHHC palmitoyltransferase family
SimilarityContains 1 DHHC-type zinc finger
Subcellular LocationMembrane ; Multi-pass membrane protein {ECO:0000305}. Golgi apparatus .
Tissue SpecificityWidely expressed. Present in Sertoli cells (at protein level)