LMPD Database

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LMP012960

UniProt Annotations

Entry Information
Gene Namephospholipase B1
Protein EntryPLB1_RAT
UniProt IDO54728
SpeciesRat
Comments
Comment typeDescription
Catalytic Activity2-lysophosphatidylcholine + H(2)O = glycerophosphocholine + a carboxylate.
Catalytic ActivityPhosphatidylcholine + H(2)O = 1- acylglycerophosphocholine + a carboxylate.
DomainRepeat 2 contains the catalytic domain.
Enzyme RegulationInhibited by diisopropyl fluorophosphate.
FunctionMembrane-associated phospholipase. Exhibits a calcium- independent broad substrate specificity including phospholipase A2/lysophospholipase activity. Preferential hydrolysis at the sn-2 position of diacylphospholipids and diacyglycerol, whereas it shows no positional specificity toward triacylglycerol. Exhibits also esterase activity toward p-nitrophenyl. May act on the brush border membrane to facilitate the absorption of digested lipids. {ECO:0000269|PubMed:11401559, ECO:0000269|PubMed:9442064, ECO:0000269|PubMed:9442065}.
PtmUndergoes proteolytic cleavage in the ileum
SimilarityBelongs to the 'GDSL' lipolytic enzyme family. Phospholipase B1 subfamily
Subcellular LocationApical cell membrane ; Single- pass type I membrane protein {ECO:0000269|PubMed:9442064, ECO:0000269|PubMed:9442065}. Note=Present in the intestinal brush border membranes.
Tissue SpecificityExpressed in the ileum mucosa, Paneth cells spermatocytes, spermatids and sperm (at protein level). Expressed in the ileum, jejunum, esophagus and testis