LMPD Database

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LMP012975

UniProt Annotations

Entry Information
Gene Nameretinol saturase (all trans retinol 13,14 reductase)
Protein EntryRETST_RAT
UniProt IDQ8VHE9
SpeciesRat
Comments
Comment typeDescription
Catalytic ActivityAll-trans-13,14-dihydroretinol + acceptor = all-trans-retinol + reduced acceptor.
CofactorName=NAD(+); Xref=ChEBI:CHEBI:57540; Evidence={ECO:0000250}; Name=NADP(+); Xref=ChEBI:CHEBI:58349; Evidence={ECO:0000250}; Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000250};
CofactorName=NAD(+); Xref=ChEBI:CHEBI:57540; Evidence= ; Name=NADP(+); Xref=ChEBI:CHEBI:58349; Evidence= ; Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence= ;
FunctionRetinol saturase carrying out the saturation of the 13- 14 double bond of all-trans-retinol to produce all-trans-13,14- dihydroretinol. Has activity toward all-trans-retinol as substrate. Does not use all-trans-retinoic acid nor 9-cis, 11-cis or 13-cis-retinol isomers as substrates. May play a role in the metabolism of vitamin A (By similarity)
FunctionRetinol saturase carrying out the saturation of the 13- 14 double bond of all-trans-retinol to produce all-trans-13,14- dihydroretinol. Has activity toward all-trans-retinol as substrate. Does not use all-trans-retinoic acid nor 9-cis, 11-cis or 13-cis-retinol isomers as substrates. May play a role in the metabolism of vitamin A (By similarity). {ECO:0000250}.
InductionDown-regulated in mammary adenocarcinomas
InductionDown-regulated in mammary adenocarcinomas. {ECO:0000269|PubMed:11753649}.
SimilarityBelongs to the carotenoid/retinoid oxidoreductase family. CrtISO subfamily
SimilarityBelongs to the carotenoid/retinoid oxidoreductase family. CrtISO subfamily. {ECO:0000305}.
Subcellular LocationEndoplasmic reticulum membrane {ECO:0000250}; Peripheral membrane protein .
Subcellular LocationEndoplasmic reticulum membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Tissue SpecificityHighly expressed in liver, kidney and heart
Tissue SpecificityHighly expressed in liver, kidney and heart. {ECO:0000269|PubMed:11753649}.