LMPD Database

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LMP013038

UniProt Annotations

Entry Information
Gene Namehydroxysteroid (17-beta) dehydrogenase 11
Protein EntryDHB11_RAT
UniProt IDQ6AYS8
SpeciesRat
Comments
Comment typeDescription
Catalytic ActivityEstradiol-17-beta + NAD(P)(+) = estrone + NAD(P)H.
FunctionCan convert androstan-3-alpha,17-beta-diol (3-alpha- diol) to androsterone in vitro, suggesting that it may participate in androgen metabolism during steroidogenesis. May act by metabolizing compounds that stimulate steroid synthesis and/or by generating metabolites that inhibit it. Has no activity toward DHEA (dehydroepiandrosterone), or A-dione (4-androste-3,17-dione), and only a slight activity toward testosterone to A-dione (By similarity)
SimilarityBelongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily
Subcellular LocationSecreted .