LMPD Database

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LMP013063

UniProt Annotations

Entry Information
Gene Nameubiquitin interaction motif containing 1
Protein EntryUIMC1_RAT
UniProt IDQ5PQK4
SpeciesRat
Comments
Comment typeDescription
DomainThe Abraxas-interacting region (AIR) mediates the interaction with FAM175A/Abraxas
DomainThe UIM-linker region between the 2 UIM repeats determines the selectivity for 'Lys-63'-linked ubiquitin. The length of the linker is important. The linker reduces the flexibility between the UIM repeats and promotes high-affinity and linkage-selective interactions (By similarity)
FunctionUbiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. May interact with monoubiquitinated histones H2A and H2B; the relevance of such results is however unclear in vivo. Does not bind Lys-48'-linked ubiquitin. May indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1 (By similarity)
PtmPhosphorylated upon DNA damage by ATM or ATR
PtmSumoylated
SimilarityBelongs to the RAP80 family
SimilarityContains 2 UIM (ubiquitin-interacting motif) repeats
Subcellular LocationNucleus . Note=Localizes at sites of DNA damage at double-strand breaks (DSBs)
SubunitComponent of the BRCA1-A complex, at least composed of the BRCA1, BARD1, UIMC1/RAP80, FAM175A/Abraxas, BRCC3/BRCC36, BRE/BRCC45 and BABAM1/NBA1. In the BRCA1-A complex, interacts directly with FAM175A/Abraxas. Interacts with ESR1, NR6A1, TSP57 and UBE2I (By similarity)