LMPD Database

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LMP013170

UniProt Annotations

Entry Information
Gene Nameprostaglandin reductase 2
Protein EntryPTGR2_RAT
UniProt IDQ5BK81
SpeciesRat
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1 ; IsoId=Q5BK81-1; Sequence=Displayed; Note=Gene prediction based on similarity to mouse ortholog. ; Name=2 ; IsoId=Q5BK81-2; Sequence=VSP_052852; Note=No experimental confirmation available. ;
Catalytic Activity11-alpha-hydroxy-9,15-dioxoprost-5-enoate + NAD(P)(+) = (5Z)-(13E)-11-alpha-hydroxy-9,15-dioxoprosta-5,13- dienoate + NAD(P)H
FunctionFunctions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto- PGE2-alpha with highest activity towards 15-keto-PGE2. Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation (By similarity)
SimilarityBelongs to the NADP-dependent oxidoreductase L4BD family
Subcellular LocationCytoplasm .
SubunitMonomer