LMPD Database

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LMP013180

UniProt Annotations

Entry Information
Gene NameRAB21, member RAS oncogene family
Protein EntryRAB21_RAT
UniProt IDQ6AXT5
SpeciesRat
Comments
Comment typeDescription
FunctionRegulates integrin internalization and recycling, but does not influence the traffic of endosomally translocated receptors in general. As a result, may regulate cell adhesion and migration. During the mitosis of adherent cells, controls the endosomal trafficking of integrins which is required for the successful completion of cytokinesis (By similarity)
SimilarityBelongs to the small GTPase superfamily. Rab family
Subcellular LocationEndoplasmic reticulum membrane; Lipid- anchor. Golgi apparatus membrane. Early endosome membrane. Cytoplasmic vesicle membrane .
SubunitInteracts with the cytoplasmic tail of integrins ITGA1, ITGA2, ITGA5, ITGA6, ITGA11 and ITGB1; this interaction is dependent upon its GDP/GTP cycle