LMPD Database

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LMP013437

UniProt Annotations

Entry Information
Gene Nameprotein arginine methyltransferase 7
Protein EntryANM7_RAT
UniProt IDQ5U4E8
SpeciesRat
Comments
Comment typeDescription
Catalytic ActivityS-adenosyl-L-methionine + arginine-[histone] = S-adenosyl-L-homocysteine + N(omega)-methyl-arginine-[histone].
Catalytic ActivityS-adenosyl-L-methionine + [myelin basic protein]-arginine = S-adenosyl-L-homocysteine + [myelin basic protein]-N(omega)-methyl-arginine.
FunctionArginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Specifically mediates the symmetric dimethylation of histone H4 'Arg-3' to form H4R3me2s. Plays a role in gene imprinting by being recruited by CTCFL at the H19 imprinted control region (ICR) and methylating histone H4 to form H4R3me2s, possibly leading to recruit DNA methyltransferases at these sites. May also play a role in embryonic stem cell (ESC) pluripotency. Also able to mediate the arginine methylation of histone H2A and myelin basic protein (MBP) in vitro; the relevance of such results is however unclear in vivo (By similarity)
SimilarityBelongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N- methyltransferase family. PRMT7 subfamily. {ECO:0000255|PROSITE- ProRule:PRU01015}.
SimilarityContains 2 SAM-dependent MTase PRMT-type domains
Subcellular LocationCytoplasm, cytosol . Nucleus .
SubunitHomodimer and heterodimer. Interacts with CTCFL, PRMT5 and SNRPD3 (By similarity)