LMPD Database

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LMP013537

UniProt Annotations

Entry Information
Gene Name3-oxoacid CoA transferase 2A
Protein EntrySCO2A_RAT
UniProt IDQ5XIJ9
SpeciesRat
Comments
Comment typeDescription
Catalytic ActivitySuccinyl-CoA + a 3-oxo acid = succinate + a 3- oxoacyl-CoA
FunctionKey enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate (By similarity). Probably play and important roles in the energy metabolism of spermatozoa (By similarity)
PathwayKetone metabolism; succinyl-CoA degradation; acetoacetyl- CoA from succinyl-CoA: step 1/1.
SimilarityBelongs to the 3-oxoacid CoA-transferase family
Subcellular LocationMitochondrion .
SubunitHomodimer
Tissue SpecificityExpressed in flagella of epididymal sperm