LMPD Database

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LMP013555

UniProt Annotations

Entry Information
Gene NameNPC1-like 1
Protein EntryNPCL1_RAT
UniProt IDQ6T3U3
SpeciesRat
Comments
Comment typeDescription
FunctionPlays a major role in cholesterol homeostasis. Is critical for the uptake of cholesterol across the plasma membrane of the intestinal enterocyte. Is the direct molecular target of ezetimibe, a drug that inhibits cholesterol absorption (By similarity). Lack of activity leads to multiple lipid transport defects. The protein may have a function in the transport of multiple lipids and their homeostasis. Acts as a negative regulator of NPC2 and down-regulates its expression and secretion by inhibiting its maturation and accelerating its degradation (By similarity)
PtmHighly glycosylated.
SimilarityBelongs to the patched family
SimilarityContains 1 SSD (sterol-sensing) domain
Subcellular LocationApical cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=Subfractionation of brush border membranes from proximal enterocytes suggests considerable association with the apical membrane fraction. Exists as a predominantly cell surface membrane expressed protein.
SubunitInteracts with RAB11A, MYO5B and RAB11FIP2. Interaction with RAB11A, MYO5B and RAB11FIP2 is required for proper transport to the plasma membrane upon cholesterol depletion (By similarity). Interacts with NPC2 (By similarity)
Tissue SpecificitySmall intestine showed the highest level of expression. Expression in other tissues including gall bladder, liver, testis and stomach is also observed. Along the duodenum- ileum axis, the levels vary in different segments of the intestine with peak expression in the proximal jejunum. Protein expression is confined to the enterocyte. Discrete localization to the epithelial layer bordering the luminal space along the crypt- villus axis. Protein expression in the enterocyte is observed closest to the luminal space. Expression in enterocytes from the proximal (jejunum) but not in the distal (ileum) region