LMPD Database

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LMP013572

UniProt Annotations

Entry Information
Gene Nameprostaglandin D2 receptor-like
Protein EntryPD2R_RAT
UniProt IDQ9R261
SpeciesRat
Comments
Comment typeDescription
FunctionReceptor for prostaglandin D2 (PGD2). The activity of this receptor is mainly mediated by G(s) proteins that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP. A mobilization of calcium is also observed, but without formation of inositol 1,4,5-trisphosphate
SimilarityBelongs to the G-protein coupled receptor 1 family
Subcellular LocationCell membrane ; Multi-pass membrane protein .
Tissue SpecificityStrongly expressed in eye and gastrointestinal tract (GIT), moderately in the brain and oviduct and weakly in the epididymis. In the eye, expressed in the epithelium of the iris and ciliary body and in photoreceptor cells of the retina. In the brain, expressed in leptomeninges, choroid plexus and spinal cord (sensory and motor neurons of the dorsal and ventral horns). In the stomach, expressed in the mucous-secreting goblet cells and the columnar epithelium. Expressed in platelets