LMPD Database

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LMP009137

UniProt Annotations

Entry Information
Gene Namequiver
Protein EntryQVR_DROME
UniProt ID
SpeciesDrosophila
Comments
Comment typeDescription
Disruption PhenotypeBoth daytime and nighttime sleep are severely reduced in both males and females. A small percentage of flies (around 9%) do not sleep at all. A moderate reduction has minimal effects on baseline sleep but markedly reduces the amount of recovery sleep after sleep deprivation. Mutants have impaired Sh-dependent K(+) current. {ECO:0000269|PubMed:18635795}.
FunctionRequired for homeostatic regulation of sleep under normal conditions and after sleep deprivation. Important regulator of the Sh K(+) channel, acting as a signaling molecule that connects sleep drive to lowered membrane excitability, possibly by enhancing K(+) channel activity and thus reducing neuronal excitability. {ECO:0000269|PubMed:18635795}.
PtmN-glycosylated. {ECO:0000269|PubMed:18635795}.
Sequence CautionSequence=AAL90233.1; Type=Miscellaneous discrepancy; Note=Several sequencing errors.; Evidence={ECO:0000305};
SimilarityBelongs to the quiver family. {ECO:0000305}.
Subcellular LocationCell membrane; Lipid-anchor, GPI-anchor.
Tissue SpecificityEnriched in brain and head. {ECO:0000269|PubMed:18635795}.
Web ResourceName=Protein Spotlight; Note=Sleepless nights - Issue 101 of January 2009; URL="http://web.expasy.org/spotlight/back_issues/101";