LMPD Database

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LMP012737

UniProt Annotations

Entry Information
Gene Namesterol regulatory element binding transcription factor 1
Protein EntrySRBP1_RAT
UniProt IDP56720
SpeciesRat
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=SREBP-1A; IsoId=P56720-2; Sequence=Displayed; Name=SREBP-1C; Synonyms=ADD1; IsoId=P56720-1; Sequence=VSP_030860;
FunctionTranscriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the fatty acid and to a lesser degree the cholesterol synthesis pathway (By similarity). Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3'). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3')
PtmAt low cholesterol the SCAP/SREBP complex is recruited into COPII vesicles for export from the ER. In the Golgi complex SREBPs are cleaved sequentially by site-1 and site-2 protease. The first cleavage by site-1 protease occurs within the luminal loop, the second cleavage by site-2 protease occurs within the first transmembrane domain and releases the transcription factor from the Golgi membrane. Apoptosis triggers cleavage by the cysteine proteases caspase-3 and caspase-7 (By similarity)
PtmPhosphorylated by AMPK, leading to suppress protein processing and nuclear translocation, and repress target gene expression. Phosphorylation at Ser-395 by SIK1 represses activity possibly by inhibiting DNA-binding (By similarity)
Sequence CautionSequence=L16995; Type=Frameshift; Positions=902, 939, 956, 972, 1016; Evidence= ;
SimilarityBelongs to the SREBP family
SimilarityContains 1 bHLH (basic helix-loop-helix) domain
Subcellular LocationEndoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle, COPII-coated vesicle membrane; Multi-pass membrane protein. Note=Moves from the endoplasmic reticulum to the Golgi in the absence of sterols.
Subcellular LocationProcessed sterol regulatory element-binding protein 1: Nucleus.
SubunitForms a tight complex with SCAP in the ER membrane. Efficient DNA binding of the soluble transcription factor fragment requires dimerization with another bHLH protein. Interacts with LMNA.
Tissue SpecificityExpressed predominantly in brown adipose tissue.