Lipidomics studies on macrophages - bone marrow-derived macrophages treated with 25-hydroxy-cholesterol +/- lipid-depleted media containing compactin

Averages of biological replicates - (GP) Glycerophospholipids Legend: : View data/graphs for replicates : View time course graphs for averages of biological replicates Ctrl: Untreated BMDM cells (control) 25-OHC: Cells treated with 25-OH-cholesterol at time 0 *: BMDM cells in lipid-depleted media containing compactin 25-OHC*: cells in lipid-depleted media containing compactin and treated with 25-OHC at time 0 PA | PC | PE | PG | PI | PS | DNA Details Time course graph (ave of biol. reps) LM_ID Name 25-OHC* * 25-OHC Ctrl 0 hrs 25-OHC* * 25-OHC Ctrl 30 min 25-OHC* * 25-OHC Ctrl 1 hr 25-OHC* * 25-OHC Ctrl 2 hrs 25-OHC* * 25-OHC Ctrl 4 hrs 25-OHC* * 25-OHC Ctrl 8 hrs 25-OHC* * 25-OHC Ctrl 12 hrs 25-OHC* * 25-OHC Ctrl 24 hrs Units . . . . Ratio plot Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp - LPI(18:0) - 34.2 - 37.8 26.8 30.4 28.4 31.3 49 31.4 32.9 40.8 45.3 37.8 39.2 43.9 50.3 72.1 63.5 46.7 59.5 45.9 92.9 33.5 65.7 72.6 42.5 36.5 144 95.1 83.4 70.4 pmol/sample Ratio plot Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp - PI(34:1) - 31.2 - 39.3 31.5 48.2 33 26.7 41.1 47 27.2 50.2 51.9 43.6 47.3 39.7 44.6 62.4 46.8 43.6 53.4 60.7 70.6 79.6 96.7 82.6 84.4 72.7 144 120 89.1 68.3 pmol/sample Ratio plot Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp - PI(34:2) - 18.1 - 21.6 16.3 22.6 17.8 15 16.7 23.2 15.1 25.8 24.1 18.1 21.7 19.6 19.2 26.7 18.1 22.1 19.5 27.1 30.2 37.2 29.3 34.9 29.1 33.3 43.5 48.2 29.1 30.2 pmol/sample Ratio plot Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp - PI(36:1) - 42.8 - 42.8 44.4 62.6 44 32.5 66.5 65.5 35 67 80.3 62.5 70.6 62 62.7 90.7 69 60.2 71.9 85.7 82.3 87.5 109 111 77.5 72.2 159 144 83.7 75.9 pmol/sample Ratio plot Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp - PI(36:2) - 82.7 - 97.5 101 139 111 78.1 127 143 98.5 162 131 105 141 135 94.5 137 127 106 103 139 136 197 207 233 155 167 286 295 177 184 pmol/sample Ratio plot Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp - PI(36:3) - 18.3 - 26.9 19.5 29.1 28.9 20 27.5 32.1 26.1 40 29.5 25 39.3 30.6 21.6 32.2 36.2 28.3 23.1 31.7 39.3 49.6 37.2 45.5 37.8 35.3 54 55.3 44.6 39 pmol/sample Ratio plot Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp - PI(36:4) - 17.7 - 28 17.9 28.1 26.3 20 25.6 31.3 23.6 37.8 24.7 22.9 38.5 30.4 19.7 27.6 36.8 27 22.4 28.2 43.8 49.2 41.4 41.2 52.3 41.1 57.3 52.4 58.8 41.7 pmol/sample Ratio plot Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp - PI(38:2) - 18.2 - 24.9 17.6 25.6 25.1 17.4 25.6 29.9 19.7 33 33.1 29.6 38.7 32.1 30.2 40.6 40.5 33.6 31.5 41 45.3 39.6 34.6 36.7 34 35.7 52.3 50 32.6 32.3 pmol/sample Ratio plot Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp - PI(38:3) - 72 - 106 72.9 107 120 76.2 104 113 93 160 126 111 182 143 104 156 164 138 110 147 190 177 129 140 146 148 176 188 132 134 pmol/sample Ratio plot Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp - PI(38:4) - 124 - 184 131 190 214 142 177 200 186 278 196 177 289 252 154 232 263 215 171 234 284 302 230 271 262 247 324 318 271 250 pmol/sample Ratio plot Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp - PI(38:5) - 74.5 - 116 85.3 119 126 87.5 101 122 111 168 121 97.2 169 161 84.5 135 142 122 92.5 136 153 179 121 144 144 144 151 159 134 149 pmol/sample Ratio plot Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp - PI(38:6) - 6.76 - 10.4 7.04 8.22 8.44 6.57 9.55 11.8 9.66 13.8 10.3 8.54 12.9 10.6 7.74 11.3 11.9 10.1 8.65 11.7 12 15.1 10.2 15 11.9 13.7 14.1 19 14.9 10.6 pmol/sample Ratio plot Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp - PI(40:4) - 7.98 - 11.5 7.12 9.75 10.6 7.71 8.02 11.9 9.22 15.8 11 9.22 16 13.7 9.29 13.2 14.9 12.7 8.83 14.4 16.2 17.6 12.5 14.5 13.8 16.2 18.4 17.6 13.9 11 pmol/sample Ratio plot Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp - PI(40:5) - 10.8 - 17.7 10.8 15.6 19.4 12.1 13.6 20.5 14.4 23.8 18.1 14.5 25.8 21.3 14.5 22.2 23.8 21.1 15.4 22.6 28.7 29.7 18.8 20.8 23 25.2 26.8 26.4 24.4 21.5 pmol/sample Ratio plot Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp - PI(40:6) - 8.83 - 14.4 8.78 12.8 14.5 9.13 12.9 17.6 12.6 20.7 14.9 12.3 20.6 17.4 11.6 17.4 18.3 17.1 12.4 19.3 22.8 23.7 14.7 22.3 19.3 20.3 21 20.9 18.5 16 pmol/sample