Microarray analysis of bone marrow-derived macrophage cells treated with Kdo₂-lipid A (KLA) and ATP

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Heatmap of ATP/KLA timecourse data for lipid category EM (Ratio to control values)

Gene Time course graph Description Treatment 15min 30min 1min 2min 4min 8min 20min Alox5 KLA  ATP  ATP+KLA arachidonate 5-lipoxygenase (Alox5), mRNA [NM_009662] KLA 0.83 0.87 0.88 0.87 0.71 0.58 0.21   ATP 1.03 1.03 1.14 1.21 0.93 0.55 0.41   ATP+KLA 0.86 0.85 0.90 0.97 0.84 0.61 0.24 Pla2g1b KLA  ATP  ATP+KLA phospholipase A2, group IB, pancreas (Pla2g1b), mRNA [NM_011107] KLA 1.00 1.01 1.01 1.11 1.00 1.28 1.00   ATP 0.98 1.03 1.09 1.03 1.01 1.02 1.04   ATP+KLA 0.93 0.94 1.01 1.00 0.94 1.09 1.07 Pla2g4a KLA  ATP  ATP+KLA phospholipase A2, group IVA (cytosolic, calcium-dependent) (Pla2g4a), mRNA [NM_008869] KLA 3.93 4.49 4.86 6.39 6.43 3.10 1.68   ATP 1.13 1.35 1.27 1.30 1.01 5.37 1.47   ATP+KLA 3.63 4.45 4.75 7.11 2.96 4.08 2.60 Pla2g4b KLA  ATP  ATP+KLA phospholipase A2, group IVB (cytosolic) (Pla2g4b), mRNA [NM_145378] KLA 1.08 1.18 0.95 1.01 0.97 0.97 0.77   ATP 1.04 1.14 1.27 0.94 0.88 1.18 0.70   ATP+KLA 1.23 1.43 1.21 1.01 1.15 1.16 0.78 Pla2g5 KLA  ATP  ATP+KLA phospholipase A2, group V (Pla2g5), transcript variant 2, mRNA [NM_011110] KLA 0.65 0.62 0.56 0.53 0.62 1.60 3.01   ATP 0.90 0.82 0.88 1.69 1.82 1.26 6.32   ATP+KLA 0.63 0.59 0.65 0.63 0.91 1.56 5.59 Pla2g6 KLA  ATP  ATP+KLA phospholipase A2, group VI (Pla2g6), mRNA [NM_016915] KLA 0.60 0.59 0.56 0.60 0.94 1.31 1.59   ATP 1.10 1.14 0.95 1.05 1.06 1.13 1.14   ATP+KLA 0.63 0.56 0.54 0.56 0.71 0.97 1.55 Ptgds KLA  ATP  ATP+KLA prostaglandin D2 synthase (brain) (Ptgds), mRNA [NM_008963] KLA 1.19 1.16 1.11 1.19 1.04 0.98 0.93   ATP 0.99 0.99 1.10 1.07 1.02 1.00 0.97   ATP+KLA 1.18 1.18 1.31 1.39 1.09 0.89 0.90 Ptges KLA  ATP  ATP+KLA prostaglandin E synthase (Ptges), mRNA [NM_022415] KLA 16.01 15.00 16.36 20.05 28.20 32.79 23.08   ATP 1.00 1.03 1.44 2.27 10.67 30.61 17.52   ATP+KLA 14.56 16.98 20.33 21.07 21.87 25.39 38.01 Ptgs1 KLA  ATP  ATP+KLA prostaglandin-endoperoxide synthase 1 (Ptgs1), mRNA [NM_008969] KLA 0.74 0.74 0.76 0.74 0.61 0.53 0.18   ATP 1.01 1.05 1.29 1.14 0.99 1.16 3.96   ATP+KLA 0.77 0.71 0.88 0.77 0.75 0.61 0.40 Ptgs2 KLA  ATP  ATP+KLA prostaglandin-endoperoxide synthase 2 (Ptgs2), mRNA [NM_011198] KLA 181.04 220.88 218.58 132.79 103.05 22.69 18.02   ATP 2.47 9.45 52.12 208.62 271.22 306.11 6.86   ATP+KLA 233.38 387.29 617.86 1069.32 608.44 290.80 112.22