LIPID MAPS® Lipidomic Ion Mobility Database

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The Lipidomic Ion Mobility database was developed in collaboration with the McLean research group at Vanderbilt University, Nashville, TN who have generated a repository (The Unified Compendium) of > 3800 experimentally acquired CCS values obtained from traceable molecular standards and measured with drift tube-mass spectrometers.

The initial database was created by mapping a subset of 835 lipid measurements to the LIPID MAPS® classification system and contains representatives from 7 of the 8 major lipid categories. The database has been expanded to include data provided by the Griffin lab at the University of Cambridge, UK, who aquired 47 Fatty Acids, for which a total of 268 conformers could be detected. Data on oxidised lipids from the Fedorova lab in Dresden was added in 2023.

The Lipidomic Ion Mobility database can be searched by lipid name and filtered by LIPID MAPS® lipid category.

Lipid Category Number of CCS Values
Fatty Acyls 572
Glycerolipids 4
Glycerophospholipids 324
Sphingolipids 147
Sterol Lipids 74
Prenol Lipids 13
Polyketides 101
TOTAL 1235
Number of Entries by LIPID MAPS® Category

References

Ion mobility conformational lipid atlas for high confidence lipidomics., (2019), Nature Communications volume 10, Article number: 985, DOI: 10.1038/s41467-019-08897-5
A Comprehensive UHPLC Ion Mobility Quadrupole Time-of-Flight Method for Profiling and Quantification of Eicosanoids, Other Oxylipins, and Fatty Acids., (2019), Anal. Chem. 91 (13), 8025-8035, DOI: 10.1021/acs.analchem.8b04615
An Interlaboratory Evaluation of Drift Tube Ion Mobility–Mass Spectrometry Collision Cross Section Measurements., (2017), Anal. Chem. 89 (17), 9048–9055, DOI: 10.1021/acs.analchem.7b01729