Microarray analysis of bone marrow-derived macrophage cells treated with Kdo₂-lipid A (KLA) and ATP

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Heatmap of ATP/KLA timecourse data for lipid category FC (Ratio to control values)

Gene Time course graph Description Treatment 15min 30min 1min 2min 4min 8min 20min Acaa1a KLA  ATP  ATP+KLA acetyl-Coenzyme A acyltransferase 1A (Acaa1a), mRNA [NM_130864] KLA 1.53 1.60 1.88 2.07 2.41 2.64 1.82   ATP 1.07 0.99 0.98 1.10 0.94 0.83 1.58   ATP+KLA 1.64 1.64 1.73 1.75 1.61 1.39 1.85 Acox1 KLA  ATP  ATP+KLA acyl-Coenzyme A oxidase 1, palmitoyl (Acox1), mRNA [NM_015729] KLA 0.79 0.81 0.78 0.68 0.66 0.69 0.81   ATP 0.97 1.09 0.93 0.90 0.81 0.78 1.22   ATP+KLA 0.81 0.82 0.69 0.68 0.59 0.70 0.88 Acox3 KLA  ATP  ATP+KLA acyl-Coenzyme A oxidase 3, pristanoyl (Acox3), mRNA [NM_030721] KLA 0.56 0.56 0.63 0.55 0.50 0.48 0.68   ATP 1.10 1.00 0.85 0.76 0.87 0.44 0.73   ATP+KLA 0.61 0.66 0.57 0.49 0.57 0.48 0.47 Elovl2 KLA  ATP  ATP+KLA elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 2 (Elovl2), mRNA [NM_019423] KLA 1.12 1.08 1.23 1.23 1.42 1.38 1.15   ATP 0.89 0.96 1.06 1.01 1.10 1.49 1.16   ATP+KLA 1.06 1.21 1.14 1.21 1.44 2.32 1.68 Elovl5 KLA  ATP  ATP+KLA ELOVL family member 5, elongation of long chain fatty acids (yeast) (Elovl5), mRNA [NM_134255] KLA 0.77 0.76 0.78 0.59 0.51 0.48 0.65   ATP 0.95 0.97 1.17 1.28 0.91 0.54 0.69   ATP+KLA 0.74 0.76 0.83 0.79 0.61 0.46 0.43 Elovl6 KLA  ATP  ATP+KLA ELOVL family member 6, elongation of long chain fatty acids (yeast) (Elovl6), mRNA [NM_130450] KLA 0.40 0.35 0.30 0.23 0.19 0.18 0.23   ATP 0.94 0.86 1.19 0.77 0.43 0.35 0.44   ATP+KLA 0.38 0.35 0.39 0.34 0.34 0.20 0.15 Fads1 KLA  ATP  ATP+KLA fatty acid desaturase 1 (Fads1), mRNA [NM_146094] KLA 0.36 0.37 0.33 0.27 0.20 0.23 0.63   ATP 0.99 1.03 0.82 0.93 0.69 0.23 0.87   ATP+KLA 0.38 0.38 0.29 0.34 0.26 0.18 0.33 Fads2 KLA  ATP  ATP+KLA fatty acid desaturase 2 (Fads2), mRNA [NM_019699] KLA 0.84 0.82 0.87 0.71 0.55 0.37 0.31   ATP 1.04 1.10 1.03 1.27 0.98 0.58 0.49   ATP+KLA 0.84 0.83 0.86 0.97 0.72 0.44 0.23 Fasn KLA  ATP  ATP+KLA fatty acid synthase (Fasn), mRNA [NM_007988] KLA 0.51 0.49 0.46 0.44 0.41 0.35 0.41   ATP 0.97 0.93 0.98 0.95 0.83 0.67 0.62   ATP+KLA 0.52 0.47 0.47 0.58 0.51 0.44 0.25 Hadha KLA  ATP  ATP+KLA 9 days embryo whole body cDNA, RIKEN full-length enriched library, clone:D030026J11 product:hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), alpha subunit, full insert KLA 0.96 0.92 0.91 0.80 0.97 0.92 0.90   ATP 0.72 0.64 0.63 0.71 0.91 0.93 0.93   ATP+KLA 0.79 0.72 0.68 0.73 0.87 0.90 0.88 Hadha KLA  ATP  ATP+KLA hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), alpha subunit (Hadha), nuclear gene encoding mitochondrial protein, mRNA [NM_178878] KLA 1.10 1.17 1.36 1.16 1.23 1.10 1.00   ATP 1.16 1.22 1.03 1.40 1.09 0.79 1.11   ATP+KLA 1.33 1.35 1.16 1.41 1.00 0.92 1.31 Pla2g1b KLA  ATP  ATP+KLA phospholipase A2, group IB, pancreas (Pla2g1b), mRNA [NM_011107] KLA 1.00 1.01 1.01 1.11 1.00 1.28 1.00   ATP 0.98 1.03 1.09 1.03 1.01 1.02 1.04   ATP+KLA 0.93 0.94 1.01 1.00 0.94 1.09 1.07 Pla2g4a KLA  ATP  ATP+KLA phospholipase A2, group IVA (cytosolic, calcium-dependent) (Pla2g4a), mRNA [NM_008869] KLA 3.93 4.49 4.86 6.39 6.43 3.10 1.68   ATP 1.13 1.35 1.27 1.30 1.01 5.37 1.47   ATP+KLA 3.63 4.45 4.75 7.11 2.96 4.08 2.60 Pla2g4b KLA  ATP  ATP+KLA phospholipase A2, group IVB (cytosolic) (Pla2g4b), mRNA [NM_145378] KLA 1.08 1.18 0.95 1.01 0.97 0.97 0.77   ATP 1.04 1.14 1.27 0.94 0.88 1.18 0.70   ATP+KLA 1.23 1.43 1.21 1.01 1.15 1.16 0.78 Pla2g5 KLA  ATP  ATP+KLA phospholipase A2, group V (Pla2g5), transcript variant 2, mRNA [NM_011110] KLA 0.65 0.62 0.56 0.53 0.62 1.60 3.01   ATP 0.90 0.82 0.88 1.69 1.82 1.26 6.32   ATP+KLA 0.63 0.59 0.65 0.63 0.91 1.56 5.59 Pla2g6 KLA  ATP  ATP+KLA phospholipase A2, group VI (Pla2g6), mRNA [NM_016915] KLA 0.60 0.59 0.56 0.60 0.94 1.31 1.59   ATP 1.10 1.14 0.95 1.05 1.06 1.13 1.14   ATP+KLA 0.63 0.56 0.54 0.56 0.71 0.97 1.55 Scd1 KLA  ATP  ATP+KLA stearoyl-Coenzyme A desaturase 1 (Scd1), mRNA [NM_009127] KLA 0.79 0.81 0.86 0.72 0.59 0.43 0.33   ATP 0.97 0.87 0.82 0.75 0.68 0.62 0.72   ATP+KLA 0.78 0.74 0.67 0.68 0.54 0.45 0.28 Scd2 KLA  ATP  ATP+KLA stearoyl-Coenzyme A desaturase 2 (Scd2), mRNA [NM_009128] KLA 0.10 0.08 0.08 0.07 0.11 0.19 0.48   ATP 1.02 0.63 0.27 0.13 0.12 0.33 0.59   ATP+KLA 0.09 0.06 0.05 0.04 0.05 0.06 0.07 Scd3 KLA  ATP  ATP+KLA stearoyl-coenzyme A desaturase 3 (Scd3), mRNA [NM_024450] KLA 1.06 1.01 1.07 1.08 1.14 1.21 1.43   ATP 1.02 1.04 1.06 1.02 1.06 1.03 1.07   ATP+KLA 1.06 1.06 0.96 1.10 1.19 1.15 1.30 Tecr KLA  ATP  ATP+KLA trans-2,3-enoyl-CoA reductase KLA 0.83 0.95 0.97 0.79 0.84 0.77 0.75   ATP 1.20 1.35 0.82 1.40 1.07 0.73 0.70   ATP+KLA 1.19 0.99 0.64 1.28 0.69 0.69 0.59