Microarray analysis of bone marrow-derived macrophage cells treated with Kdo₂-lipid A (KLA) and ATP

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Heatmap of ATP/KLA timecourse data for lipid category GL,GP (Ratio to control values)

Gene Time course graph Description Treatment 15min 30min 1min 2min 4min 8min 20min Agpat6 KLA  ATP  ATP+KLA 1-acylglycerol-3-phosphate O-acyltransferase 6 (lysophosphatidic acid acyltransferase, zeta) (Agpat6), mRNA [NM_018743] KLA 1.14 1.08 1.21 1.15 1.17 1.25 1.50   ATP 1.05 1.02 0.91 0.91 1.11 1.42 1.26   ATP+KLA 1.16 1.17 0.96 0.87 1.00 1.40 1.35 Cdipt KLA  ATP  ATP+KLA CDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase) (Cdipt), mRNA [NM_026638] KLA 0.75 0.74 0.71 0.67 0.79 0.87 1.15   ATP 1.07 1.03 0.76 0.81 0.75 0.77 1.18   ATP+KLA 0.82 0.72 0.51 0.53 0.51 0.72 1.22 Cds1 KLA  ATP  ATP+KLA CDP-diacylglycerol synthase 1 (Cds1), mRNA [NM_173370] KLA 2.81 2.96 3.62 3.43 3.28 1.96 0.97   ATP 1.07 1.05 0.86 0.90 0.78 0.82 1.17   ATP+KLA 2.84 2.92 2.34 2.04 1.61 1.01 0.97 Chkb KLA  ATP  ATP+KLA choline kinase beta (Chkb), mRNA [NM_007692] KLA 0.70 0.72 0.70 0.66 0.86 0.79 0.78   ATP 0.96 0.86 0.72 0.86 1.35 1.43 0.95   ATP+KLA 0.68 0.55 0.52 0.61 1.24 1.30 1.10 Chpt1 KLA  ATP  ATP+KLA choline phosphotransferase 1 (Chpt1), mRNA [NM_144807] KLA 1.16 1.18 1.24 1.15 1.16 1.09 1.23   ATP 1.01 1.05 1.16 1.09 0.98 0.96 0.98   ATP+KLA 1.20 1.15 1.13 1.18 1.17 1.33 1.25 Dgkz KLA  ATP  ATP+KLA diacylglycerol kinase zeta (Dgkz), mRNA [NM_138306] KLA 0.21 0.22 0.23 0.29 0.56 1.23 1.39   ATP 1.08 1.25 0.90 1.22 0.85 0.57 1.44   ATP+KLA 0.23 0.22 0.18 0.31 0.60 0.80 1.45 Etnk1 KLA  ATP  ATP+KLA gb|PREDICTED: Mus musculus ethanolamine kinase 1 (Etnk1), mRNA [XM_908334] KLA 5.38 5.56 5.81 5.53 4.73 4.65 2.51   ATP 1.01 1.05 1.13 1.21 1.24 2.34 2.30   ATP+KLA 5.41 5.64 5.14 6.04 5.38 4.90 5.42 Gpam KLA  ATP  ATP+KLA glycerol-3-phosphate acyltransferase, mitochondrial (Gpam), nuclear gene encoding mitochondrial protein, mRNA [NM_008149] KLA 1.04 0.97 1.00 1.04 0.90 0.96 1.00   ATP 0.98 1.18 1.10 0.95 0.70 0.98 1.37   ATP+KLA 1.03 1.06 1.05 1.01 0.79 0.89 1.00 Pcyt1a KLA  ATP  ATP+KLA 10 days neonate cerebellum cDNA, RIKEN full-length enriched library, clone:B930020C23 product:phosphate cytidylyltransferase 1, choline, alpha isoform, full insert sequence [AK163685] KLA 0.63 0.65 0.76 0.82 0.87 1.04 0.67   ATP 1.00 1.10 0.81 1.07 2.85 1.72 1.60   ATP+KLA 0.64 0.63 0.48 0.97 2.62 2.63 1.66 Pcyt1a KLA  ATP  ATP+KLA phosphate cytidylyltransferase 1, choline, alpha isoform (Pcyt1a), mRNA [NM_009981] KLA 0.67 0.77 0.90 0.96 0.99 1.16 0.81   ATP 0.93 1.04 0.85 1.22 2.93 1.57 1.91   ATP+KLA 0.72 0.73 0.82 1.17 2.79 2.47 1.62 Pcyt2 KLA  ATP  ATP+KLA phosphate cytidylyltransferase 2, ethanolamine (Pcyt2), mRNA [NM_024229] KLA 0.58 0.57 0.56 0.46 0.49 0.42 0.54   ATP 0.97 0.94 1.03 0.99 0.70 0.66 1.11   ATP+KLA 0.59 0.58 0.60 0.54 0.43 0.34 0.45 Pemt KLA  ATP  ATP+KLA phosphatidylethanolamine N-methyltransferase (Pemt), nuclear gene encoding mitochondrial protein, mRNA [NM_008819] KLA 1.00 1.08 1.08 0.99 0.92 0.83 0.93   ATP 1.08 1.16 1.04 1.22 1.02 0.89 0.84   ATP+KLA 1.14 1.10 0.92 1.05 0.83 0.76 0.71 Pisd KLA  ATP  ATP+KLA phosphatidylserine decarboxylase (Pisd), mRNA [NM_177298] KLA 0.71 0.66 0.72 0.80 0.95 0.98 1.03   ATP 1.00 0.89 0.79 0.67 0.96 1.16 0.99   ATP+KLA 0.69 0.65 0.58 0.58 0.90 1.12 0.99 Pla2g1b KLA  ATP  ATP+KLA phospholipase A2, group IB, pancreas (Pla2g1b), mRNA [NM_011107] KLA 1.00 1.01 1.01 1.11 1.00 1.28 1.00   ATP 0.98 1.03 1.09 1.03 1.01 1.02 1.04   ATP+KLA 0.93 0.94 1.01 1.00 0.94 1.09 1.07 Pld1 KLA  ATP  ATP+KLA phospholipase D1 (Pld1), mRNA [NM_008875] KLA 0.71 0.73 0.67 0.73 0.88 0.96 1.25   ATP 0.99 0.88 0.73 0.68 0.45 1.23 1.12   ATP+KLA 0.70 0.67 0.58 0.59 0.48 0.91 1.48 Pnpla3 KLA  ATP  ATP+KLA patatin-like phospholipase domain containing 3 (Pnpla3), mRNA [NM_054088] KLA 0.88 0.99 1.04 0.97 1.00 0.91 1.03   ATP 0.95 1.03 1.05 1.03 1.01 0.93 0.99   ATP+KLA 1.02 1.05 1.00 0.94 0.95 0.98 0.95 Ppap2a KLA  ATP  ATP+KLA phosphatidic acid phosphatase 2a (Ppap2a), transcript variant 2, mRNA [NM_008903] KLA 2.62 2.85 4.01 5.61 7.83 10.88 16.34   ATP 1.00 1.02 1.09 1.28 1.26 2.38 1.44   ATP+KLA 2.78 2.77 2.99 3.42 2.85 3.58 6.58 Ppap2b KLA  ATP  ATP+KLA phosphatidic acid phosphatase type 2B (Ppap2b), mRNA [NM_080555] KLA 2.73 2.72 2.65 2.39 1.07 1.48 3.26   ATP 0.99 0.97 1.60 2.76 18.64 27.23 9.19   ATP+KLA 2.69 2.80 4.36 4.20 14.33 15.32 17.91 Ppap2c KLA  ATP  ATP+KLA phosphatidic acid phosphatase type 2c (Ppap2c), mRNA [NM_015817] KLA 0.94 0.88 0.91 0.79 0.65 0.46 0.51   ATP 1.01 1.03 1.00 1.12 1.24 0.90 0.83   ATP+KLA 0.95 0.93 0.87 0.95 0.79 0.63 0.43 Ptdss1 KLA  ATP  ATP+KLA phosphatidylserine synthase 1 (Ptdss1), mRNA [NM_008959] KLA 0.88 0.95 0.96 0.86 0.88 0.92 1.05   ATP 1.02 1.05 0.90 1.08 0.99 0.93 1.17   ATP+KLA 0.95 0.93 0.81 0.85 0.67 0.83 1.10 Ptdss2 KLA  ATP  ATP+KLA phosphatidylserine synthase 2 (Ptdss2), mRNA [NM_013782] KLA 0.95 0.95 1.01 1.06 1.17 1.33 1.26   ATP 0.90 0.93 0.92 1.04 0.83 0.85 1.34   ATP+KLA 0.93 0.95 0.93 0.90 0.90 0.96 1.42