Microarray analysis of bone marrow-derived macrophage cells treated with Kdo2-lipid A (KLA) and ATP

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Kdo2-Lipid A / ATP gene array data - treatment:control ratios

KEGG pathway: Citrate cycle (TCA cycle) (mmu00020)

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Gene symbol    Time course plot Accession Description Treatment 15min 30min 1hr 2hr 4hr 8hr 20hr
1500032O
14Rik
KLA  ATP  ATP+KLA
 AK005350 adult male cerebellum cDNA, RIKEN full-length enriched library, clone:1500032O14 product:succinate dehydrogenase complex, subunit A, flavoprotein (Fp), full insert sequence. [AK005350] KLA 1.01 .97 .97 .98 1.01 1.05 1.04
ATP .61 .42 .41 .55 1.05 1.12 .96
KLA/ATP .62 .53 .54 .68 1.10 1.02 .88
4933405O
20Rik
KLA  ATP  ATP+KLA
 NM_172901 RIKEN cDNA 4933405O20 gene (4933405O20Rik), mRNA [NM_172901] KLA .98 .99 1.01 1.07 1.03 1.01 1.03
ATP .95 .97 .99 .96 .99 1.01 1.02
KLA/ATP .93 1.01 .99 .98 .98 .92 .96
AK031343
KLA  ATP  ATP+KLA
 AK031343 13 days embryo male testis cDNA, RIKEN full-length enriched library, clone:6030410A06 product:unclassifiable, full insert sequence [AK031343] KLA 1.03 .97 .92 1.01 .97 .90 .94
ATP 1.00 1.00 .92 .95 .97 .99 .98
KLA/ATP .98 1.01 .86 .99 .91 .93 1.00
Acly
KLA  ATP  ATP+KLA
 AK043466 7 days neonate cerebellum cDNA, RIKEN full-length enriched library, clone:A730098H14 product:unclassifiable, full insert sequence. [AK043466] KLA .99 .97 .93 .93 .97 .98 .94
ATP 1.01 1.00 .93 .98 1.00 .95 1.00
KLA/ATP .99 1.01 .91 .94 .97 .95 1.02
Acly
KLA  ATP  ATP+KLA
 NM_134037 ATP citrate lyase (Acly), mRNA [NM_134037] KLA 1.03 1.18 1.07 .98 .99 .92 .97
ATP 1.04 1.26 1.05 1.29 .98 .91 1.07
KLA/ATP 1.19 1.12 .98 1.46 .88 .94 .81
Aco1
KLA  ATP  ATP+KLA
 NM_007386 aconitase 1 (Aco1), mRNA [NM_007386] KLA .82 .85 .80 .78 .73 .74 .84
ATP 1.02 1.07 1.04 .96 .95 .88 .83
KLA/ATP .83 .86 .81 .80 .76 .73 .62
Aco2
KLA  ATP  ATP+KLA
 AK029122 10 days neonate skin cDNA, RIKEN full-length enriched library, clone:4732494K09 product:hypothetical protein, full insert sequence [AK029122] KLA 1.02 1.02 .99 .98 .97 1.04 .83
ATP .98 1.04 1.05 .95 .95 1.02 1.00
KLA/ATP .96 .95 1.00 1.04 1.06 1.03 .99
Aco2
KLA  ATP  ATP+KLA
 NM_080633 aconitase 2, mitochondrial (Aco2), nuclear gene encoding mitochondrial protein, mRNA [NM_080633] KLA .93 .96 .97 .91 .97 .99 1.07
ATP 1.05 1.04 .98 .92 .90 .83 .99
KLA/ATP 1.01 1.06 .86 .89 .83 .93 .93
Cs
KLA  ATP  ATP+KLA
 NM_026444 citrate synthase (Cs), nuclear gene encoding mitochondrial protein, mRNA [NM_026444] KLA 1.09 1.07 1.04 1.05 1.08 1.15 1.14
ATP .91 .93 1.02 .90 .90 1.08 1.38
KLA/ATP .99 1.04 1.09 .98 .98 .90 1.13
Csl
KLA  ATP  ATP+KLA
 NM_027945 citrate synthase like (Csl), mRNA [NM_027945] KLA 1.41 1.32 1.35 1.51 1.61 1.39 1.58
ATP 1.17 1.15 .98 1.23 1.18 1.33 2.00
KLA/ATP 1.32 1.53 1.45 1.59 1.13 1.14 1.77
Dlat
KLA  ATP  ATP+KLA
 NM_145614 dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) (Dlat), mRNA [NM_145614] KLA 1.00 1.05 1.03 .95 .87 .83 1.15
ATP .94 1.01 1.22 1.09 .80 .57 .91
KLA/ATP .96 1.01 1.05 .98 .70 .48 .54
Dld
KLA  ATP  ATP+KLA
 NM_007861 dihydrolipoamide dehydrogenase (Dld), mRNA [NM_007861] KLA 1.60 1.66 1.84 1.66 1.47 1.16 1.17
ATP 1.05 1.08 1.21 1.06 1.15 1.24 .93
KLA/ATP 1.52 1.63 1.65 1.42 1.17 1.05 .79
Dld
KLA  ATP  ATP+KLA
 U73445 dihydrolipoamide dehydrogenase (Dld) mRNA, complete cds. [U73445] KLA 1.48 1.43 1.43 1.47 1.25 1.05 1.16
ATP .94 .93 1.18 .86 1.02 1.46 .97
KLA/ATP 1.39 1.37 1.50 1.10 1.11 1.14 .85
Dlst
KLA  ATP  ATP+KLA
 AK171100 NOD-derived CD11c +ve dendritic cells cDNA, RIKEN full-length enriched library, clone:F630223O05 product:dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex), full insert sequence [AK171100] KLA .90 .87 .88 .83 1.10 .86 1.09
ATP .97 .78 .47 .80 2.22 1.46 1.21
KLA/ATP 1.00 .91 .66 .76 1.24 1.06 1.04
Dlst
KLA  ATP  ATP+KLA
 NM_030225 dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) (Dlst), mRNA [NM_030225] KLA 1.15 1.22 1.20 1.11 1.02 .97 1.13
ATP 1.02 1.01 1.02 .95 1.01 1.36 1.19
KLA/ATP 1.23 1.29 1.23 1.19 .99 .98 .99
Fh1
KLA  ATP  ATP+KLA
 NM_010209 fumarate hydratase 1 (Fh1), mRNA [NM_010209] KLA 1.00 .88 .79 .83 .55 .36 .39
ATP 1.05 1.05 1.08 .98 .89 .49 .45
KLA/ATP .91 .95 1.06 .92 .72 .41 .18
Idh1
KLA  ATP  ATP+KLA
 NM_010497 isocitrate dehydrogenase 1 (NADP+), soluble (Idh1), transcript variant 2, mRNA [NM_010497] KLA .71 .74 .69 .70 .54 .45 .63
ATP 1.22 1.28 1.00 1.28 1.06 .62 .81
KLA/ATP .76 .81 .68 .88 .55 .47 .40
Idh2
KLA  ATP  ATP+KLA
 NM_173011 isocitrate dehydrogenase 2 (NADP+), mitochondrial (Idh2), nuclear gene encoding mitochondrial protein, mRNA [NM_173011] KLA .83 .83 .88 .94 .66 .31 .38
ATP 1.04 1.09 1.14 1.48 1.26 .39 .49
KLA/ATP .90 .92 1.04 1.10 .82 .41 .20
Idh3a
KLA  ATP  ATP+KLA
 NM_029573 isocitrate dehydrogenase 3 (NAD+) alpha (Idh3a), nuclear gene encoding mitochondrial protein, mRNA [NM_029573] KLA .99 1.06 .85 .83 .67 .51 .73
ATP .95 1.07 1.12 1.22 .93 .46 .52
KLA/ATP .92 1.00 .91 1.12 .75 .42 .21
Idh3b
KLA  ATP  ATP+KLA
 NM_130884 isocitrate dehydrogenase 3 (NAD+) beta (Idh3b), nuclear gene encoding mitochondrial protein, mRNA [NM_130884] KLA .89 .94 .94 .89 .97 1.00 1.12
ATP 1.01 1.07 .94 1.16 .94 .52 .68
KLA/ATP .92 .94 .78 1.05 .78 .73 .58
Idh3g
KLA  ATP  ATP+KLA
 NM_008323 isocitrate dehydrogenase 3 (NAD+), gamma (Idh3g), nuclear gene encoding mitochondrial protein, mRNA [NM_008323] KLA .74 .69 .66 .68 .61 .55 .63
ATP .94 .91 1.06 1.09 .93 .66 .62
KLA/ATP .72 .74 .80 .80 .73 .56 .48
Mdh1
KLA  ATP  ATP+KLA
 AK077724 8 days embryo whole body cDNA, RIKEN full-length enriched library, clone:5730556L21 product:unclassifiable, full insert sequence [AK077724] KLA .85 .75 .69 .67 .72 .81 .82
ATP .93 .83 .61 .59 .72 .72 .88
KLA/ATP .79 .76 .67 .58 .74 .74 .80
Mdh1
KLA  ATP  ATP+KLA
 NM_008618 malate dehydrogenase 1, NAD (soluble) (Mdh1), mRNA [NM_008618] KLA .79 .72 .66 .66 .52 .49 .57
ATP .98 1.00 1.17 1.09 .96 .70 .66
KLA/ATP .70 .73 .92 .78 .76 .65 .52
Mdh2
KLA  ATP  ATP+KLA
 NM_008617 malate dehydrogenase 2, NAD (mitochondrial) (Mdh2), nuclear gene encoding mitochondrial protein, mRNA [NM_008617] KLA .90 .91 .81 .86 .81 .91 1.26
ATP .96 .86 1.04 .80 1.01 1.36 1.33
KLA/ATP .87 .79 1.04 .71 .95 1.04 .95
Mm.1845
KLA  ATP  ATP+KLA
 142351600 Unknown KLA .93 .92 .89 .81 .76 .84 .65
ATP 1.01 .94 1.08 1.00 .77 1.95 1.13
KLA/ATP .91 .84 .85 .81 .59 .66 .77
Mm.31830
2
KLA  ATP  ATP+KLA
 124487482 Unknown KLA 1.02 1.02 1.02 1.06 1.03 .98 1.05
ATP 1.00 .99 1.04 1.17 1.04 .98 .96
KLA/ATP 1.04 1.02 1.22 1.05 .99 .99 .99
Ogdh
KLA  ATP  ATP+KLA
 NM_010956 oxoglutarate dehydrogenase (lipoamide) (Ogdh), nuclear gene encoding mitochondrial protein, mRNA [NM_010956] KLA 1.00 1.05 1.10 .95 1.06 1.08 1.30
ATP 1.10 1.28 .95 1.23 .93 1.15 1.82
KLA/ATP 1.27 1.11 .81 1.21 .76 1.13 1.83
Ogdhl
KLA  ATP  ATP+KLA
 NM_001081130 oxoglutarate dehydrogenase-like (Ogdhl), mRNA [NM_001081130] KLA 1.03 1.07 1.03 1.02 1.00 .97 .91
ATP .94 .99 .98 .99 .93 .99 1.01
KLA/ATP .97 1.02 1.03 .93 .95 .90 1.04
Pck2
KLA  ATP  ATP+KLA
 NM_028994 phosphoenolpyruvate carboxykinase 2 (mitochondrial) (Pck2), nuclear gene encoding mitochondrial protein, mRNA [NM_028994] KLA .40 .37 .32 .28 .37 .56 .55
ATP .99 .96 .86 .94 1.02 .57 .77
KLA/ATP .40 .37 .31 .35 .42 .35 .46
Pcx
KLA  ATP  ATP+KLA
 NM_008797 pyruvate carboxylase (Pcx), nuclear gene encoding mitochondrial protein, mRNA [NM_008797] KLA 1.28 1.34 1.44 1.30 1.34 1.23 .91
ATP 1.11 1.09 1.19 1.29 1.19 1.49 1.16
KLA/ATP 1.34 1.41 1.63 1.53 1.39 1.05 1.15
Pdha1
KLA  ATP  ATP+KLA
 NM_008810 pyruvate dehydrogenase E1 alpha 1 (Pdha1), nuclear gene encoding mitochondrial protein, mRNA [NM_008810] KLA .92 .96 .94 .92 .94 1.04 1.18
ATP .98 1.03 1.14 1.10 1.02 1.05 .91
KLA/ATP .93 .93 .97 .94 .81 .82 .69
Pdha2
KLA  ATP  ATP+KLA
 NM_008811 pyruvate dehydrogenase E1 alpha 2 (Pdha2), mRNA [NM_008811] KLA 1.04 .95 .98 .99 1.00 1.04 .98
ATP 1.00 .97 .95 1.00 1.01 .99 1.01
KLA/ATP 1.05 1.07 .91 1.02 .98 1.00 1.05
Pdhb
KLA  ATP  ATP+KLA
 NM_024221 pyruvate dehydrogenase (lipoamide) beta (Pdhb), mRNA [NM_024221] KLA 1.14 1.05 1.00 .97 1.03 .90 .88
ATP 1.08 1.10 1.12 1.23 1.24 1.24 1.21
KLA/ATP 1.01 1.16 1.13 1.21 1.23 1.44 1.26
Pdhx
KLA  ATP  ATP+KLA
 NM_175094 pyruvate dehydrogenase complex, component X (Pdhx), nuclear gene encoding mitochondrial protein, mRNA [NM_175094] KLA 1.15 1.12 1.12 1.12 1.07 1.14 1.12
ATP 1.04 1.02 1.14 .94 1.03 1.30 .98
KLA/ATP 1.25 1.20 1.26 1.05 1.08 1.38 .89
Sdha
KLA  ATP  ATP+KLA
 NM_023281 succinate dehydrogenase complex, subunit A, flavoprotein (Fp) (Sdha), nuclear gene encoding mitochondrial protein, mRNA [NM_023281] KLA .97 1.04 1.13 .96 .99 .90 1.09
ATP 1.09 1.20 .93 1.16 .88 .55 .94
KLA/ATP 1.12 1.16 .82 1.02 .65 .65 .78
Sdhb
KLA  ATP  ATP+KLA
 NM_023374 succinate dehydrogenase complex, subunit B, iron sulfur (Ip) (Sdhb), mRNA [NM_023374] KLA .83 .83 .84 .90 .88 1.22 1.74
ATP 1.08 1.02 1.04 1.19 1.05 .63 .87
KLA/ATP .86 .84 .89 .89 .95 .94 .95
Sdhc
KLA  ATP  ATP+KLA
 NM_025321 succinate dehydrogenase complex, subunit C, integral membrane protein (Sdhc), nuclear gene encoding mitochondrial protein, mRNA [NM_025321] KLA .90 .95 1.00 .93 .95 .84 1.01
ATP 1.19 1.21 .98 1.38 1.06 .58 .88
KLA/ATP 1.07 1.18 .93 1.11 .90 .80 .75
Sdhd
KLA  ATP  ATP+KLA
 NM_025848 succinate dehydrogenase complex, subunit D, integral membrane protein (Sdhd), nuclear gene encoding mitochondrial protein, mRNA [NM_025848] KLA .94 .92 .93 .92 .93 .92 1.07
ATP .98 1.02 1.05 1.16 .96 .91 .94
KLA/ATP .90 .98 .91 1.01 .94 1.06 1.01
Sucla2
KLA  ATP  ATP+KLA
 AK016060 adult male testis cDNA, RIKEN full-length enriched library, clone:4930547K18 product:unclassifiable, full insert sequence. [AK016060] KLA .92 1.07 .96 1.02 .97 .95 1.02
ATP 1.08 1.02 1.00 1.06 .92 1.01 .94
KLA/ATP .94 1.04 1.04 .96 .94 .94 .90
Sucla2
KLA  ATP  ATP+KLA
 NM_011506 succinate-Coenzyme A ligase, ADP-forming, beta subunit (Sucla2), nuclear gene encoding mitochondrial protein, mRNA [NM_011506] KLA 1.10 1.02 1.00 1.06 .87 .81 .86
ATP .98 .95 1.30 1.02 .93 .69 .72
KLA/ATP .98 1.02 1.35 1.04 1.00 .61 .52
Suclg1
KLA  ATP  ATP+KLA
 NM_019879 succinate-CoA ligase, GDP-forming, alpha subunit (Suclg1), mRNA [NM_019879] KLA .87 .88 .81 .81 .84 .79 .89
ATP 1.14 1.06 1.05 1.06 .87 .41 .81
KLA/ATP .93 .92 .92 .92 .76 .49 .49
Suclg2
KLA  ATP  ATP+KLA
 NM_011507 succinate-Coenzyme A ligase, GDP-forming, beta subunit (Suclg2), mRNA [NM_011507] KLA .99 1.07 1.08 .88 .74 .49 .67
ATP 1.00 1.14 1.15 1.44 .91 .37 .45
KLA/ATP 1.08 1.08 .94 1.18 .65 .40 .35