Microarray analysis of bone marrow-derived macrophage cells treated with Kdo2-lipid A (KLA) and ATP

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Kdo2-Lipid A / ATP gene array data - treatment:control ratios

KEGG pathway: Primary bile acid biosynthesis (mmu00120)

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Gene symbol    Time course plot Accession Description Treatment 15min 30min 1hr 2hr 4hr 8hr 20hr
AK087232
KLA  ATP  ATP+KLA
AK087232 0 day neonate lung cDNA, RIKEN full-length enriched library, clone:E030037J19 product:unclassifiable, full insert sequence. [AK087232] KLA .99 1.12 1.03 1.03 1.01 .89 1.05
ATP 1.01 1.00 1.04 1.06 1.01 1.01 .92
KLA/ATP 1.02 1.05 .97 1.00 1.05 .84 .98
Acot8
KLA  ATP  ATP+KLA
NM_133240 acyl-CoA thioesterase 8 (Acot8), mRNA [NM_133240] KLA 1.03 1.01 .85 1.11 1.32 1.56 1.41
ATP .98 1.02 1.00 1.07 .85 .95 1.38
KLA/ATP 1.04 .89 1.01 1.18 1.03 .96 1.70
Acox2
KLA  ATP  ATP+KLA
NM_053115 acyl-Coenzyme A oxidase 2, branched chain (Acox2), mRNA [NM_053115] KLA .99 1.04 1.04 1.06 1.01 1.01 .99
ATP 1.06 1.08 .97 1.04 1.02 1.00 1.02
KLA/ATP 1.07 1.05 1.03 1.01 1.01 1.04 1.02
Akr1d1
KLA  ATP  ATP+KLA
NM_145364 aldo-keto reductase family 1, member D1 (Akr1d1), mRNA [NM_145364] KLA 1.00 1.04 1.01 1.02 .98 1.01 .97
ATP 1.01 .99 .99 1.04 1.01 .99 1.00
KLA/ATP .98 1.03 .93 .96 .99 1.08 1.02
Amacr
KLA  ATP  ATP+KLA
NM_008537 alpha-methylacyl-CoA racemase (Amacr), mRNA [NM_008537] KLA .64 .63 .59 .57 .51 .48 .77
ATP .99 .93 1.20 1.14 .69 .61 1.01
KLA/ATP .62 .65 .73 .82 .67 .67 .51
Baat
KLA  ATP  ATP+KLA
NM_007519 bile acid-Coenzyme A: amino acid N-acyltransferase (Baat), mRNA [NM_007519] KLA .98 .99 1.01 .95 .97 .97 1.01
ATP .97 .97 1.01 .99 1.12 1.01 1.00
KLA/ATP 1.02 1.04 1.00 1.05 1.10 .99 1.01
Ch25h
KLA  ATP  ATP+KLA
NM_009890 cholesterol 25-hydroxylase (Ch25h), mRNA [NM_009890] KLA 11.10 11.52 17.65 19.84 9.53 5.77 .63
ATP 1.63 1.73 2.93 3.18 4.70 2.08 .09
KLA/ATP 10.54 12.33 25.06 31.45 23.23 8.11 .78
Cyp27a1
KLA  ATP  ATP+KLA
NM_024264 cytochrome P450, family 27, subfamily a, polypeptide 1 (Cyp27a1), nuclear gene encoding mitochondrial protein, mRNA [NM_024264] KLA 1.03 .98 1.22 1.00 .87 .57 .40
ATP 1.07 1.06 .99 1.18 .71 .41 .38
KLA/ATP 1.02 1.10 1.24 1.03 .72 .50 .34
Cyp39a1
KLA  ATP  ATP+KLA
NM_018887 cytochrome P450, family 39, subfamily a, polypeptide 1 (Cyp39a1), mRNA [NM_018887] KLA 1.18 1.20 1.24 1.25 1.13 .98 .61
ATP 1.02 .97 1.06 1.00 .96 1.12 .66
KLA/ATP 1.16 1.23 1.17 1.24 1.10 1.09 .64
Cyp46a1
KLA  ATP  ATP+KLA
NM_010010 cytochrome P450, family 46, subfamily a, polypeptide 1 (Cyp46a1), mRNA [NM_010010] KLA 1.65 1.63 1.66 1.89 1.58 1.99 1.60
ATP 1.02 .95 1.13 1.12 1.18 1.41 1.43
KLA/ATP 1.54 1.51 1.98 1.68 1.84 1.67 1.83
Cyp7a1
KLA  ATP  ATP+KLA
NM_007824 cytochrome P450, family 7, subfamily a, polypeptide 1 (Cyp7a1), mRNA [NM_007824] KLA 1.03 .99 .97 1.00 .97 1.03 .99
ATP .99 .99 1.02 1.04 .99 .99 1.03
KLA/ATP 1.03 1.00 .99 .99 .91 .97 .99
Cyp7b1
KLA  ATP  ATP+KLA
NM_007825 cytochrome P450, family 7, subfamily b, polypeptide 1 (Cyp7b1), mRNA [NM_007825] KLA 1.16 1.20 1.26 1.21 1.10 1.05 1.07
ATP 1.06 1.02 1.01 .95 .99 1.00 .98
KLA/ATP 1.27 1.31 1.24 1.13 1.16 1.10 1.03
Cyp8b1
KLA  ATP  ATP+KLA
NM_010012 cytochrome P450, family 8, subfamily b, polypeptide 1 (Cyp8b1), mRNA [NM_010012] KLA .98 1.06 1.04 1.00 1.03 1.03 1.06
ATP 1.00 .99 1.02 1.04 1.06 1.01 1.09
KLA/ATP 1.08 .99 1.05 1.19 1.11 1.11 1.01
Hsd17b4
KLA  ATP  ATP+KLA
NM_008292 hydroxysteroid (17-beta) dehydrogenase 4 (Hsd17b4), mRNA [NM_008292] KLA .86 .77 .82 .76 .61 .63 .59
ATP .98 .98 1.31 1.09 1.02 .80 .64
KLA/ATP .80 .86 1.04 .87 .85 .68 .54
Hsd3b7
KLA  ATP  ATP+KLA
NM_133943 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 (Hsd3b7), transcript variant 1, mRNA [NM_133943] KLA .44 .39 .41 .32 .35 .47 .79
ATP 1.17 1.01 .82 .89 1.02 .96 1.61
KLA/ATP .47 .42 .35 .34 .49 .56 .89
Mm.10984
KLA  ATP  ATP+KLA
6678010 Unknown KLA .98 1.03 .96 1.03 .98 .98 .98
ATP .96 .96 1.01 1.06 .93 .93 .93
KLA/ATP .96 .93 .84 .93 1.08 1.19 1.04
Scp2
KLA  ATP  ATP+KLA
NM_011327 sterol carrier protein 2, liver (Scp2), mRNA [NM_011327] KLA .88 .85 .85 .77 .71 .68 .66
ATP 1.03 1.13 1.25 1.38 1.10 .63 .47
KLA/ATP .85 .88 .91 1.06 .83 .58 .38
Slc27a5
KLA  ATP  ATP+KLA
NM_009512 solute carrier family 27 (fatty acid transporter), member 5 (Slc27a5), mRNA [NM_009512] KLA .94 .95 .95 1.02 1.03 .97 1.02
ATP 1.03 .95 1.04 1.10 .97 .91 1.00
KLA/ATP 1.06 .96 .94 .99 1.04 1.01 1.04