Microarray analysis of bone marrow-derived macrophage cells treated with Kdo2-lipid A (KLA) and ATP

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Kdo2-Lipid A / ATP gene array data - treatment:control ratios

KEGG pathway: Phosphatidylinositol signaling system (mmu04070)

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Gene symbol    Time course plot Accession Description Treatment 15min 30min 1hr 2hr 4hr 8hr 20hr
AK086155
KLA  ATP  ATP+KLA
 AK086155 15 days embryo head cDNA, RIKEN full-length enriched library, clone:D930008J19 product:unclassifiable, full insert sequence. [AK086155] KLA 1.02 1.05 1.02 1.02 .99 1.08 .93
ATP .98 1.06 1.35 1.04 .94 1.11 1.08
KLA/ATP .98 .94 1.11 1.03 1.04 1.04 1.13
Calm1
KLA  ATP  ATP+KLA
 NM_009790 calmodulin 1 (Calm1), mRNA [NM_009790] KLA 1.20 1.26 1.30 1.06 1.16 1.09 1.18
ATP 1.07 1.20 1.00 1.29 .99 .64 .58
KLA/ATP 1.31 1.31 .93 1.31 .97 .83 .59
Calm2
KLA  ATP  ATP+KLA
 NM_007589 calmodulin 2 (Calm2), mRNA [NM_007589] KLA .79 .81 .71 .67 .54 .45 .64
ATP .99 1.03 1.04 .93 .82 .52 .76
KLA/ATP .76 .78 .76 .77 .73 .47 .42
Calm3
KLA  ATP  ATP+KLA
 NM_007590 calmodulin 3 (Calm3), mRNA [NM_007590] KLA .95 .96 .93 1.03 1.05 1.08 1.00
ATP .93 .96 .99 .97 .93 .84 .72
KLA/ATP .89 .93 .90 .91 1.02 .98 .70
Calm4
KLA  ATP  ATP+KLA
 NM_020036 calmodulin 4 (Calm4), mRNA [NM_020036] KLA 1.02 .96 1.05 1.00 .99 1.00 1.01
ATP 1.10 1.05 1.03 1.01 .94 .98 .98
KLA/ATP .99 1.12 1.01 1.03 .98 1.07 1.02
Calm5
KLA  ATP  ATP+KLA
 NM_001008706 calmodulin 5 (Calm5), mRNA [NM_001008706] KLA 1.02 1.11 .99 .98 1.07 1.01 1.09
ATP 1.07 1.05 1.04 1.04 1.01 1.04 .99
KLA/ATP 1.00 1.00 .97 1.07 1.00 1.07 .98
Calml3
KLA  ATP  ATP+KLA
 NM_027416 calmodulin-like 3 (Calml3), mRNA [NM_027416] KLA 1.01 .95 1.05 .91 1.01 .98 .89
ATP .91 1.05 1.04 1.01 .93 1.07 .99
KLA/ATP 1.01 .96 .97 .96 .97 .92 .99
Cdipt
KLA  ATP  ATP+KLA
 NM_026638 CDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase) (Cdipt), mRNA [NM_026638] KLA .75 .74 .71 .67 .79 .87 1.15
ATP 1.07 1.03 .76 .81 .75 .77 1.18
KLA/ATP .82 .72 .51 .53 .51 .72 1.22
Cds1
KLA  ATP  ATP+KLA
 NM_173370 CDP-diacylglycerol synthase 1 (Cds1), mRNA [NM_173370] KLA 2.81 2.96 3.63 3.43 3.28 1.96 .97
ATP 1.08 1.05 .86 .90 .78 .83 1.17
KLA/ATP 2.84 2.92 2.34 2.04 1.61 1.01 .98
Cds2
KLA  ATP  ATP+KLA
 NM_138651 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2 (Cds2), mRNA [NM_138651] KLA 1.05 1.06 1.06 1.17 1.32 1.73 2.21
ATP .97 .93 .91 .77 .97 1.88 3.79
KLA/ATP 1.09 1.12 1.07 .94 1.16 1.49 4.77
Dgka
KLA  ATP  ATP+KLA
 NM_016811 diacylglycerol kinase, alpha (Dgka), mRNA [NM_016811] KLA 3.34 3.15 3.23 3.20 2.95 1.29 .45
ATP 1.11 .97 1.01 .90 1.32 1.39 1.33
KLA/ATP 2.97 3.42 3.95 2.85 2.49 1.47 1.21
Dgkb
KLA  ATP  ATP+KLA
 AK032509 adult male olfactory brain cDNA, RIKEN full-length enriched library, clone:6430574F24 product:DIACYLGLYCEROL KINASE, BETA (EC 2.7.1.107) (DIGLYCERIDE KINASE) (DGK- BETA) (DAG KINASE BETA) (90 KDA DIACYLGLYCEROL KINASE) homolog [Rattus nor KLA .92 .92 .98 .93 1.01 1.06 1.00
ATP 1.03 1.05 .97 1.00 .95 1.03 .99
KLA/ATP 1.00 1.07 1.02 .97 1.00 .96 .97
Dgkb
KLA  ATP  ATP+KLA
 AK083222 adult male hippocampus cDNA, RIKEN full-length enriched library, clone:C630029D13 product:DIACYLGLYCEROL KINASE, BETA (EC 2.7.1.107) (DIGLYCERIDE KINASE) (DGK- BETA) (DAG KINASE BETA) (90 KDA DIACYLGLYCEROL KINASE) homolog [Rattus norvegi KLA 1.02 1.02 1.12 1.01 1.00 1.05 .99
ATP .97 1.01 1.06 .95 1.07 1.03 1.03
KLA/ATP .95 .99 1.05 1.02 1.04 .96 1.06
Dgkb
KLA  ATP  ATP+KLA
 AK122355 mRNA for mKIAA0718 protein [AK122355] KLA 1.03 .96 1.11 1.02 .95 .94 .97
ATP 1.00 .99 1.09 1.01 1.02 .96 .95
KLA/ATP .97 1.00 1.05 1.03 .95 1.02 .95
Dgkb
KLA  ATP  ATP+KLA
 NM_178681 diacylglycerol kinase, beta (Dgkb), mRNA [NM_178681] KLA 1.05 1.08 1.03 1.04 .94 1.01 1.04
ATP 1.04 1.02 1.04 .95 1.01 1.03 1.05
KLA/ATP 1.09 .95 1.00 1.03 1.06 1.05 1.05
Dgkd
KLA  ATP  ATP+KLA
 AK076439 0 day neonate head cDNA, RIKEN full-length enriched library, clone:4832425N18 product:DIACYLGLYCEROL KINASE, DELTA (EC 2.7.1.107) (DIGLYCERIDE KINASE) (DGK-DELTA) (DAG KINASE DELTA) (130 KDA DIACYLGLYCEROL KINASE) (FRAGMENT) homolog [Homo KLA .43 .42 .38 .38 .44 .36 .28
ATP 1.08 1.06 .96 1.28 1.01 .42 .25
KLA/ATP .42 .41 .38 .39 .46 .40 .23
Dgkd
KLA  ATP  ATP+KLA
 AK172901 mRNA for mKIAA0145 protein [AK172901] KLA .27 .25 .22 .22 .23 .23 .22
ATP .87 .79 .81 .66 .58 .34 .31
KLA/ATP .22 .22 .19 .15 .20 .22 .15
Dgke
KLA  ATP  ATP+KLA
 NM_019505 diacylglycerol kinase, epsilon (Dgke), mRNA [NM_019505] KLA 1.17 1.16 1.09 .92 .86 .99 1.25
ATP 1.02 1.01 .92 .79 .99 1.14 1.10
KLA/ATP 1.19 1.16 .98 .87 .97 1.05 .88
Dgkg
KLA  ATP  ATP+KLA
 AK089261 NOD-derived CD11c +ve dendritic cells cDNA, RIKEN full-length enriched library, clone:F630107L03 product:SIMILAR TO DIACYLGLYCEROL KINASE 3 (GAMMA) homolog [Mus musculus], full insert sequence. [AK089261] KLA .95 .91 .97 .98 .97 .93 .96
ATP 1.04 1.02 .96 .93 .98 .89 .88
KLA/ATP 1.02 .99 .92 .86 .95 .92 .90
Dgkg
KLA  ATP  ATP+KLA
 NM_138650 diacylglycerol kinase, gamma (Dgkg), mRNA [NM_138650] KLA .65 .64 .62 .78 .86 .68 .53
ATP .92 .99 1.04 .83 .67 .71 .55
KLA/ATP .60 .66 .66 .65 .84 1.00 .59
Dgkh
KLA  ATP  ATP+KLA
 AK031069 13 days embryo forelimb cDNA, RIKEN full-length enriched library, clone:5930402B05 product:DIACYLGLYCEROL KINASE, DELTA (EC 2.7.1.107) (DIGLYCERIDE KINASE) (DGK- DELTA) (DAG KINASE DELTA) (130 KDA DIACYLGLYCEROL KINASE) (DIACYLGLYCEROL KI KLA 3.02 2.91 2.42 2.25 1.93 1.46 1.40
ATP 1.04 1.08 1.10 1.28 1.46 1.35 .98
KLA/ATP 3.66 4.04 3.53 1.88 1.69 1.34 1.47
Dgkh
KLA  ATP  ATP+KLA
 NM_001081336 diacylglycerol kinase, eta (Dgkh), mRNA [NM_001081336] KLA 6.71 7.34 7.44 7.69 6.90 4.13 3.15
ATP .98 .96 1.02 1.20 2.01 3.95 2.09
KLA/ATP 6.79 7.17 6.53 7.03 4.73 5.21 5.62
Dgki
KLA  ATP  ATP+KLA
 AK086550 15 days embryo head cDNA, RIKEN full-length enriched library, clone:D930036J18 product:DIACYLGLYCEROL KINASE, IOTA (EC 2.7.1.107) (DIGLYCERIDE KINASE) (DGK- IOTA) (DAG KINASE IOTA) homolog [Homo sapiens], full insert sequence. [AK086550] KLA 1.03 1.00 .96 1.07 1.00 1.08 .95
ATP 1.06 .99 1.02 .96 .98 1.02 1.03
KLA/ATP .99 .99 .99 .97 .99 .92 .99
Dgki
KLA  ATP  ATP+KLA
 NM_001081206 diacylglycerol kinase, iota (Dgki), mRNA [NM_001081206] KLA .99 .96 .89 .99 .92 .98 1.02
ATP 1.00 1.01 .95 1.00 .95 .90 1.02
KLA/ATP .91 .86 1.02 .99 1.02 .90 .98
Dgkq
KLA  ATP  ATP+KLA
 NM_199011 diacylglycerol kinase, theta (Dgkq), mRNA [NM_199011] KLA 1.09 .95 1.05 .98 .93 .96 1.11
ATP .99 .78 .66 .44 .99 1.04 1.23
KLA/ATP .98 .73 .66 .47 .67 .89 1.15
Dgkz
KLA  ATP  ATP+KLA
 NM_138306 diacylglycerol kinase zeta (Dgkz), mRNA [NM_138306] KLA .21 .22 .23 .29 .56 1.23 1.39
ATP 1.08 1.25 .90 1.22 .85 .57 1.44
KLA/ATP .23 .22 .18 .31 .60 .80 1.45
Impa1
KLA  ATP  ATP+KLA
 NM_018864 inositol (myo)-1(or 4)-monophosphatase 1 (Impa1), mRNA [NM_018864] KLA .96 .92 .90 .96 .97 1.04 1.10
ATP 1.13 1.12 1.17 1.23 1.80 1.87 1.41
KLA/ATP .92 .99 1.01 1.06 1.50 1.62 1.29
Impa2
KLA  ATP  ATP+KLA
 NM_053261 inositol (myo)-1(or 4)-monophosphatase 2 (Impa2), mRNA [NM_053261] KLA .74 .70 .67 .66 .47 .34 .21
ATP .95 .84 1.13 1.12 .78 .26 .24
KLA/ATP .64 .65 .85 .82 .67 .31 .17
Impad1
KLA  ATP  ATP+KLA
 AK147096 17 days embryo kidney cDNA, RIKEN full-length enriched library, clone:I920165A15 product:hypothetical protein, full insert sequence [AK147096] KLA 1.24 1.16 1.08 .87 .84 .79 .67
ATP 1.01 .98 .87 .50 1.58 1.49 .50
KLA/ATP 1.17 1.08 .95 .59 1.31 .99 .41
Impad1
KLA  ATP  ATP+KLA
 NM_177730 inositol monophosphatase domain containing 1 (Impad1), mRNA [NM_177730] KLA 1.83 1.73 1.69 1.97 1.48 1.27 1.26
ATP 1.04 .91 .89 .57 1.14 3.17 2.06
KLA/ATP 1.67 1.65 1.64 .98 1.14 2.21 3.24
Inpp1
KLA  ATP  ATP+KLA
 AK009002 adult male tongue cDNA, RIKEN full-length enriched library, clone:2300002C06 product:unclassifiable, full insert sequence. [AK009002] KLA 1.33 1.23 1.55 1.72 1.37 1.24 .76
ATP .95 .81 1.03 .79 .56 .87 .70
KLA/ATP 1.08 1.04 1.17 1.04 .89 .95 .92
Inpp1
KLA  ATP  ATP+KLA
 NM_008384 inositol polyphosphate-1-phosphatase (Inpp1), mRNA [NM_008384] KLA 1.43 1.67 2.01 2.24 1.74 1.68 1.01
ATP 1.10 1.00 .97 1.01 .73 1.01 .95
KLA/ATP 1.52 1.63 1.66 1.42 1.07 1.57 1.55
Inpp4a
KLA  ATP  ATP+KLA
 NM_030266 inositol polyphosphate-4-phosphatase, type I (Inpp4a), transcript variant 1, mRNA [NM_030266] KLA 1.25 1.48 1.49 1.81 2.10 1.96 1.57
ATP .91 .89 .94 1.01 1.15 1.91 2.75
KLA/ATP 1.31 1.15 1.12 1.22 1.36 2.03 4.30
Inpp4a
KLA  ATP  ATP+KLA
 NM_172971 inositol polyphosphate-4-phosphatase, type I (Inpp4a), transcript variant 2, mRNA [NM_172971] KLA 1.05 1.09 1.20 1.18 1.27 1.06 1.05
ATP 1.07 1.00 .98 .98 1.06 1.00 1.34
KLA/ATP 1.12 1.10 .97 1.08 1.16 .96 1.00
Inpp4b
KLA  ATP  ATP+KLA
 AK053554 0 day neonate eyeball cDNA, RIKEN full-length enriched library, clone:E130107I17 product:INOSITOL POLYPHOSPHATE 4-PHOSPHATASE TYPE II-ALPHA homolog [Rattus norvegicus], full insert sequence [AK053554] KLA .64 .55 .53 .51 .41 .54 .72
ATP .99 .98 1.17 .82 .65 .47 .50
KLA/ATP .57 .58 .71 .49 .52 .40 .26
Inpp4b
KLA  ATP  ATP+KLA
 NM_001024617 inositol polyphosphate-4-phosphatase, type II (Inpp4b), mRNA [NM_001024617] KLA .72 .73 .54 .69 .58 .65 .90
ATP 1.10 1.11 .99 .95 .76 .52 .65
KLA/ATP .72 .65 .70 .76 .65 .60 .41
Inpp5a
KLA  ATP  ATP+KLA
 NM_183144 inositol polyphosphate-5-phosphatase A (Inpp5a), mRNA [NM_183144] KLA .69 .67 .56 .50 .52 .83 1.14
ATP .97 1.04 .97 1.34 1.22 2.44 1.59
KLA/ATP .66 .65 .53 .58 .76 2.72 1.65
Inpp5b
KLA  ATP  ATP+KLA
 AF040095 inositol polyphosphate 5-phosphatase II splice variant (INPP5P) mRNA, partial cds. [AF040095] KLA .99 .98 1.05 1.03 1.06 1.15 1.09
ATP 1.05 1.00 .97 1.10 1.04 .99 1.00
KLA/ATP 1.03 .98 2.59 .99 1.05 1.05 1.20
Inpp5b
KLA  ATP  ATP+KLA
 NM_008385 inositol polyphosphate-5-phosphatase B (Inpp5b), nuclear gene encoding mitochondrial protein, mRNA [NM_008385] KLA 3.86 4.11 5.04 4.87 5.30 4.56 2.35
ATP .95 .97 .87 .85 1.15 1.62 1.53
KLA/ATP 4.32 4.36 4.10 4.65 3.31 3.30 2.63
Inpp5d
KLA  ATP  ATP+KLA
 NM_010566 inositol polyphosphate-5-phosphatase D (Inpp5d), transcript variant 1, mRNA [NM_010566] KLA .17 .15 .13 .20 .56 1.17 .81
ATP 1.09 1.05 .86 .70 .37 .42 1.25
KLA/ATP .18 .15 .14 .12 .17 .37 1.19
Inpp5e
KLA  ATP  ATP+KLA
 NM_033134 inositol polyphosphate-5-phosphatase E (Inpp5e), mRNA [NM_033134] KLA .78 .76 .84 .81 .91 .96 1.16
ATP 1.17 1.19 .92 .82 .64 .87 1.30
KLA/ATP .88 .85 .74 .69 .60 .78 1.26
Inppl1
KLA  ATP  ATP+KLA
 NM_010567 inositol polyphosphate phosphatase-like 1 (Inppl1), transcript variant 1, mRNA [NM_010567] KLA .82 .80 .73 .81 .79 .72 .94
ATP 1.05 1.04 .69 .58 .56 .87 .98
KLA/ATP .90 .83 .58 .46 .87 1.07 1.34
Ippk
KLA  ATP  ATP+KLA
 NM_199056 inositol 1,3,4,5,6-pentakisphosphate 2-kinase (Ippk), mRNA [NM_199056] KLA .92 .89 .86 .89 .91 .98 1.06
ATP 1.02 1.05 .88 .73 1.71 1.23 1.10
KLA/ATP .88 .85 .83 .71 .77 1.07 .84
Itpk1
KLA  ATP  ATP+KLA
 NM_172584 inositol 1,3,4-triphosphate 5/6 kinase (Itpk1), mRNA [NM_172584] KLA 1.80 1.90 1.99 2.00 1.71 1.70 1.57
ATP 1.02 1.04 .98 1.13 1.20 1.21 .99
KLA/ATP 2.15 1.89 1.63 1.91 1.33 1.69 1.53
Itpka
KLA  ATP  ATP+KLA
 NM_146125 inositol 1,4,5-trisphosphate 3-kinase A (Itpka), mRNA [NM_146125] KLA 6.50 5.98 5.46 4.17 2.98 2.72 1.97
ATP 1.13 .98 1.19 1.19 2.36 2.47 1.17
KLA/ATP 7.72 7.92 10.01 7.02 8.80 6.84 1.93
Itpkc
KLA  ATP  ATP+KLA
 AK051297 12 days embryo spinal ganglion cDNA, RIKEN full-length enriched library, clone:D130031K05 product:weakly similar to INOSITOL 1,4,5-TRISPHOSPHATE 3-KINASE C [Homo sapiens], full insert sequence. [AK051297] KLA 1.15 1.02 1.00 1.09 1.07 1.03 1.00
ATP .91 1.03 1.02 .99 .98 1.03 1.02
KLA/ATP .94 .95 1.06 .99 .95 .98 1.02
Itpkc
KLA  ATP  ATP+KLA
 NM_181593 inositol 1,4,5-trisphosphate 3-kinase C (Itpkc), mRNA [NM_181593] KLA .76 .68 .76 1.00 1.61 1.01 1.14
ATP 1.18 1.09 1.14 4.49 3.58 1.64 1.04
KLA/ATP .85 .78 1.05 2.67 3.12 1.34 1.41
Itpr1
KLA  ATP  ATP+KLA
 NM_010585 inositol 1,4,5-triphosphate receptor 1 (Itpr1), mRNA [NM_010585] KLA 3.66 3.69 6.74 8.11 7.08 4.40 1.22
ATP 1.08 .95 1.19 .94 1.09 1.00 .68
KLA/ATP 3.48 3.58 5.86 6.03 4.01 2.31 .97
Itpr2
KLA  ATP  ATP+KLA
 NM_019923 inositol 1,4,5-triphosphate receptor 2 (Itpr2), transcript variant 1, mRNA [NM_019923] KLA 1.41 1.38 1.43 1.42 1.30 1.07 1.01
ATP 1.00 1.00 .97 .97 1.07 1.15 1.06
KLA/ATP 1.39 1.48 1.64 1.42 1.07 .83 .95
Itpr3
KLA  ATP  ATP+KLA
 NM_080553 inositol 1,4,5-triphosphate receptor 3 (Itpr3), mRNA [NM_080553] KLA .55 .51 .45 .41 .34 .34 .45
ATP 1.01 .92 1.02 .57 .46 .34 1.22
KLA/ATP .56 .48 .48 .29 .33 .27 .65
Mm.18707
9
KLA  ATP  ATP+KLA
 149268188 Unknown KLA 4.07 3.11 3.86 4.46 3.31 3.46 1.63
ATP 1.17 .95 1.34 .60 1.22 1.61 1.03
KLA/ATP 3.87 3.25 5.63 2.01 3.05 3.28 2.19
Mm.21312
8
KLA  ATP  ATP+KLA
 141801344 Unknown KLA .96 .95 .83 .77 .52 .99 1.32
ATP .80 .82 1.09 .80 .83 1.19 1.46
KLA/ATP .78 .92 .98 .62 .71 .94 1.41
Mm.25381
9
KLA  ATP  ATP+KLA
 118130676 Unknown KLA 1.81 1.88 1.96 1.62 1.89 2.44 1.56
ATP .92 .91 1.24 1.01 1.16 2.06 1.95
KLA/ATP 1.62 1.86 1.86 1.41 1.89 2.37 1.97
Mm.29073
1
KLA  ATP  ATP+KLA
 125347157 Unknown KLA .98 .99 1.12 1.02 1.04 1.04 1.05
ATP 1.02 1.06 .97 1.05 .99 1.07 1.02
KLA/ATP .96 .96 .99 1.10 1.07 1.03 1.01
Mm.38329
7
KLA  ATP  ATP+KLA
 124487166 Unknown KLA 2.05 2.34 2.70 2.62 3.57 3.14 2.09
ATP 1.14 1.43 1.16 2.23 1.65 1.29 1.61
KLA/ATP 2.51 2.51 1.90 3.84 2.23 2.63 3.57
Mm.41173
7
KLA  ATP  ATP+KLA
 124486740 Unknown KLA 6.95 6.26 6.49 5.66 6.34 2.93 3.01
ATP 1.18 1.40 1.03 1.27 1.96 1.87 1.53
KLA/ATP 6.62 7.00 6.07 6.81 2.75 2.22 2.84
Mm.42677
1
KLA  ATP  ATP+KLA
 149234310 Unknown KLA .98 .96 .91 1.07 1.00 .99 .98
ATP .96 1.00 .97 .94 1.03 .95 1.01
KLA/ATP 1.01 .92 .96 .96 1.02 .99 1.00
Mm.44250
5
KLA  ATP  ATP+KLA
 124487070 Unknown KLA .93 .96 1.03 1.01 .97 .93 1.17
ATP 1.04 .91 .96 .96 .99 .89 .96
KLA/ATP .95 .89 .70 1.01 .95 1.00 .96
Mm.44463
KLA  ATP  ATP+KLA
 118129851 Unknown KLA 1.01 .98 .97 1.02 .93 1.06 1.05
ATP .97 1.01 1.04 1.06 1.02 1.08 .97
KLA/ATP 1.02 1.06 .95 1.04 1.09 1.14 1.03
Mtm1
KLA  ATP  ATP+KLA
 BC066847 cDNA clone IMAGE:30056108, containing frame-shift errors [BC066847] KLA 1.95 1.54 1.59 1.45 1.67 1.72 1.56
ATP 1.13 .99 1.79 .67 1.45 1.50 1.16
KLA/ATP 1.94 1.67 2.49 .85 1.57 1.41 1.69
Mtm1
KLA  ATP  ATP+KLA
 NM_019926 X-linked myotubular myopathy gene 1 (Mtm1), mRNA [NM_019926] KLA 1.83 1.97 2.17 2.00 2.01 1.87 2.29
ATP 1.10 1.30 1.18 1.32 .93 1.12 1.07
KLA/ATP 2.00 2.06 1.71 2.12 1.12 1.14 1.76
Ocrl
KLA  ATP  ATP+KLA
 NM_177215 oculocerebrorenal syndrome of Lowe (Ocrl), mRNA [NM_177215] KLA .99 .89 .92 .90 .90 1.11 1.10
ATP 1.02 1.03 1.17 .91 .65 .58 1.04
KLA/ATP .93 .90 .90 .75 .58 .54 .81
Pi4k2a
KLA  ATP  ATP+KLA
 NM_145501 phosphatidylinositol 4-kinase type 2 alpha (Pi4k2a), mRNA [NM_145501] KLA 1.89 1.83 2.04 2.30 2.46 2.05 1.32
ATP .95 .93 .93 .89 1.73 1.92 1.92
KLA/ATP 1.74 1.80 1.76 1.87 2.87 3.06 2.17
Pi4k2b
KLA  ATP  ATP+KLA
 NM_025951 phosphatidylinositol 4-kinase type 2 beta (Pi4k2b), transcript variant 1, mRNA [NM_025951] KLA 2.43 2.74 2.72 2.24 1.73 1.50 1.40
ATP 1.05 1.21 1.09 1.18 2.83 2.89 1.13
KLA/ATP 2.57 2.54 2.01 2.52 3.67 3.33 1.88
Pi4k2b
KLA  ATP  ATP+KLA
 NM_028744 phosphatidylinositol 4-kinase type 2 beta (Pi4k2b), transcript variant 2, mRNA [NM_028744] KLA 1.95 2.36 2.66 2.48 2.11 1.86 1.76
ATP 1.03 1.13 1.13 1.26 2.32 3.45 1.82
KLA/ATP 2.20 2.30 1.94 2.27 2.45 3.17 3.44
Pi4ka
KLA  ATP  ATP+KLA
 NM_001001983 phosphatidylinositol 4-kinase, catalytic, alpha polypeptide (Pi4ka), mRNA [NM_001001983] KLA 1.06 1.04 1.08 1.09 1.10 .94 .79
ATP 1.02 .99 1.06 .85 1.13 .82 .96
KLA/ATP 1.06 1.02 1.20 .90 1.27 .93 .56
Pi4kb
KLA  ATP  ATP+KLA
 NM_175356 phosphatidylinositol 4-kinase, catalytic, beta polypeptide (Pi4kb), mRNA [NM_175356] KLA .96 .93 .97 1.08 1.24 1.40 1.15
ATP 1.22 1.22 1.14 1.46 1.44 1.15 1.67
KLA/ATP 1.18 1.13 .93 1.19 1.22 1.46 1.18
Pib5pa
KLA  ATP  ATP+KLA
 NM_172439 phosphatidylinositol (4,5) bisphosphate 5-phosphatase, A (Pib5pa), mRNA [NM_172439] KLA 1.02 .98 .92 1.00 .93 .94 1.06
ATP 1.02 1.13 .96 1.00 .95 .89 1.21
KLA/ATP .95 1.00 .90 .91 .88 .93 1.85
Pik3c2a
KLA  ATP  ATP+KLA
 AK013614 adult male hippocampus cDNA, RIKEN full-length enriched library, clone:2900035A08 product:phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide, full insert sequence. [AK013614] KLA .74 .78 .79 .84 .92 .94 1.06
ATP 1.06 .97 1.01 .84 .84 1.01 1.21
KLA/ATP .75 .70 .74 .76 .80 .88 1.15
Pik3c2a
KLA  ATP  ATP+KLA
 NM_011083 phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide (Pik3c2a), mRNA [NM_011083] KLA .77 .75 .74 .86 .90 .93 1.10
ATP 1.20 1.37 1.39 1.09 1.24 1.48 1.18
KLA/ATP .82 .77 .84 1.03 .95 1.28 1.34
Pik3c2g
KLA  ATP  ATP+KLA
 NM_207683 phosphatidylinositol 3-kinase, C2 domain containing, gamma polypeptide (Pik3c2g), transcript variant 1, mRNA [NM_207683] KLA 1.06 1.04 1.07 1.03 1.00 1.06 1.07
ATP 1.04 1.02 1.06 1.00 .98 .98 .97
KLA/ATP 1.06 1.02 1.01 1.03 1.02 1.04 1.07
Pik3c3
KLA  ATP  ATP+KLA
 NM_181414 phosphoinositide-3-kinase, class 3 (Pik3c3), mRNA [NM_181414] KLA .85 .82 .90 .91 .99 1.01 .87
ATP .92 1.02 .97 1.08 .60 .82 .87
KLA/ATP .80 .86 .79 .90 .66 .94 .92
Pik3ca
KLA  ATP  ATP+KLA
 ENSMUST00000108243 ens|Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (EC 2.7.1.153) (PI3-kinase p110 subunit alpha) (PtdIns-3- kinase p110) (PI3K). [Source:Uniprot/SWISSPROT;Acc:P42337] [ENSMUST00000108243] KLA 1.07 1.01 .91 .90 .98 .96 .86
ATP 1.03 .87 1.12 .63 1.22 1.86 .60
KLA/ATP 1.05 .82 .91 .61 1.17 1.26 .63
Pik3ca
KLA  ATP  ATP+KLA
 NM_008839 phosphatidylinositol 3-kinase, catalytic, alpha polypeptide (Pik3ca), mRNA [NM_008839] KLA 1.15 1.11 1.05 .82 .99 1.03 1.27
ATP .98 1.00 .79 .75 .96 1.32 1.10
KLA/ATP 1.10 .98 .64 .72 .80 1.20 1.41
Pik3cb
KLA  ATP  ATP+KLA
 NM_029094 phosphatidylinositol 3-kinase, catalytic, beta polypeptide (Pik3cb), mRNA [NM_029094] KLA 1.06 1.06 1.03 .73 .68 .98 1.69
ATP 1.04 1.21 .95 1.02 .85 .93 1.73
KLA/ATP 1.15 1.27 .73 .83 .58 .81 1.81
Pik3cd
KLA  ATP  ATP+KLA
 NM_008840 phosphatidylinositol 3-kinase catalytic delta polypeptide (Pik3cd), transcript variant 1, mRNA [NM_008840] KLA 2.28 2.42 3.10 4.17 3.35 2.31 1.34
ATP 1.02 .91 .99 .63 .30 .67 .80
KLA/ATP 2.14 2.23 2.70 1.51 1.17 .85 .72
Pik3cd
KLA  ATP  ATP+KLA
 U86587 phosphatidylinositol 3-kinase catalytic subunit p110 delta mRNA, complete cds. [U86587] KLA 2.21 2.24 3.71 3.17 3.67 2.66 1.48
ATP 1.00 1.03 .93 .96 .46 .75 .97
KLA/ATP 2.27 2.32 1.97 2.02 1.01 .99 .98
Pik3cg
KLA  ATP  ATP+KLA
 NM_020272 phosphoinositide-3-kinase, catalytic, gamma polypeptide (Pik3cg), mRNA [NM_020272] KLA .53 .53 .61 .64 .97 .86 .79
ATP 1.01 1.13 .88 .89 .52 .53 .53
KLA/ATP .58 .53 .43 .60 .40 .43 .62
Pik3r1
KLA  ATP  ATP+KLA
 NM_001077495 phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha) (Pik3r1), transcript variant 2, mRNA [NM_001077495] KLA 1.05 1.07 1.03 1.00 1.01 1.20 .85
ATP .97 1.02 1.48 1.42 1.76 1.33 1.23
KLA/ATP 1.11 1.12 1.06 1.17 1.24 .99 1.12
Pik3r2
KLA  ATP  ATP+KLA
 NM_008841 phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 2 (p85 beta) (Pik3r2), mRNA [NM_008841] KLA .50 .50 .48 .43 .46 .66 .75
ATP .78 .68 .45 .43 .28 .57 1.37
KLA/ATP .49 .38 .32 .33 .38 .67 1.10
Pik3r3
KLA  ATP  ATP+KLA
 NM_181585 phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 3 (p55) (Pik3r3), mRNA [NM_181585] KLA 1.59 1.49 1.37 1.17 1.05 1.55 1.41
ATP 1.12 1.00 1.33 1.70 2.01 2.37 2.02
KLA/ATP 1.63 1.54 1.58 1.70 2.43 2.68 1.92
Pik3r5
KLA  ATP  ATP+KLA
 NM_177320 phosphoinositide-3-kinase, regulatory subunit 5, p101 (Pik3r5), mRNA [NM_177320] KLA 3.57 3.58 4.16 3.54 4.11 2.59 2.39
ATP 1.08 1.08 .93 1.67 3.11 1.88 1.34
KLA/ATP 3.91 3.70 3.30 3.80 2.70 2.04 3.00
Pip4k2a
KLA  ATP  ATP+KLA
 NM_008845 phosphatidylinositol-5-phosphate 4-kinase, type II, alpha (Pip4k2a), mRNA [NM_008845] KLA .56 .55 .57 .71 .81 .75 .73
ATP .98 1.04 .92 1.19 .99 .74 .59
KLA/ATP .55 .55 .50 .58 .60 .59 .76
Pip4k2b
KLA  ATP  ATP+KLA
 AB054987 pipk type II beta mRNA for Phosphatidyl inositol phosphate kinase type II beta, partial cds. [AB054987] KLA 1.09 1.03 1.08 1.13 1.07 1.00 .92
ATP 1.14 .98 .98 1.01 1.16 1.18 .93
KLA/ATP 1.00 1.08 1.06 1.04 1.16 1.09 1.07
Pip4k2b
KLA  ATP  ATP+KLA
 NM_054051 phosphatidylinositol-5-phosphate 4-kinase, type II, beta (Pip4k2b), mRNA [NM_054051] KLA .45 .47 .40 .50 .73 1.06 1.14
ATP 1.00 1.04 1.02 .85 .60 .63 .73
KLA/ATP .46 .45 .41 .44 .54 .54 .42
Pip4k2c
KLA  ATP  ATP+KLA
 NM_054097 phosphatidylinositol-5-phosphate 4-kinase, type II, gamma (Pip4k2c), mRNA [NM_054097] KLA .65 .65 .67 .71 .79 .88 .95
ATP 1.01 1.01 .90 .84 1.27 1.48 1.33
KLA/ATP .63 .65 .57 .53 1.09 1.50 1.44
Pip5k1a
KLA  ATP  ATP+KLA
 NM_008847 phosphatidylinositol-4-phosphate 5-kinase, type 1 alpha (Pip5k1a), mRNA [NM_008847] KLA 1.99 1.84 1.66 1.49 1.49 1.37 1.57
ATP 1.05 1.06 .89 1.54 4.20 2.72 1.58
KLA/ATP 1.95 1.90 1.55 1.60 3.26 2.64 2.25
Pip5k1b
KLA  ATP  ATP+KLA
 NM_008846 phosphatidylinositol-4-phosphate 5-kinase, type 1 beta (Pip5k1b), mRNA [NM_008846] KLA 1.24 1.35 1.11 .92 .57 .72 .86
ATP .86 1.00 .96 1.15 .85 .74 .89
KLA/ATP 1.20 1.22 .97 1.00 .78 .76 1.06
Pip5k1c
KLA  ATP  ATP+KLA
 BC094665 phosphatidylinositol-4-phosphate 5-kinase, type 1 gamma, mRNA (cDNA clone MGC:102155 IMAGE:30356181), complete cds [BC094665] KLA .82 .90 .90 .70 .96 .86 1.21
ATP 1.19 1.45 .92 1.64 1.17 .83 1.33
KLA/ATP .97 1.21 .66 1.20 .91 .92 1.69
Pip5k1c
KLA  ATP  ATP+KLA
 NM_008844 phosphatidylinositol-4-phosphate 5-kinase, type 1 gamma (Pip5k1c), mRNA [NM_008844] KLA 1.40 1.36 1.38 1.39 1.30 1.30 1.27
ATP 1.01 1.16 1.12 1.46 1.38 1.35 1.21
KLA/ATP 1.39 1.44 1.44 1.64 1.41 1.45 1.53
Pip5k3
KLA  ATP  ATP+KLA
 NM_011086 phosphatidylinositol-3-phosphate/phosphatidylinositol 5-kinase, type III (Pip5k3), mRNA [NM_011086] KLA 2.92 2.86 2.69 1.86 1.49 1.25 1.14
ATP 1.15 1.23 1.19 1.19 1.63 1.06 1.18
KLA/ATP 3.09 3.42 2.64 2.17 1.71 1.25 1.14
Plcb1
KLA  ATP  ATP+KLA
 AK129166 mRNA for mKIAA0581 protein [AK129166] KLA 1.02 .98 .91 .91 .92 .95 .89
ATP 1.03 1.02 1.02 1.01 .90 1.02 1.04
KLA/ATP .98 .97 .91 .93 .92 1.01 1.16
Plcb1
KLA  ATP  ATP+KLA
 NM_019677 phospholipase C, beta 1 (Plcb1), mRNA [NM_019677] KLA .99 .94 .95 .97 .93 .92 .91
ATP 1.00 .96 .99 .95 .99 1.03 .98
KLA/ATP .93 .96 .94 .93 .87 1.00 1.06
Plcb2
KLA  ATP  ATP+KLA
 NM_177568 phospholipase C, beta 2 (Plcb2), mRNA [NM_177568] KLA .70 .68 .64 .67 .65 .76 .88
ATP .95 .94 1.04 .94 .72 .57 1.19
KLA/ATP .69 .68 .72 .63 .65 .55 .70
Plcb3
KLA  ATP  ATP+KLA
 NM_008874 phospholipase C, beta 3 (Plcb3), mRNA [NM_008874] KLA 1.72 1.78 1.82 1.65 1.67 1.44 1.21
ATP .97 1.04 .81 .87 .78 .88 .94
KLA/ATP 1.69 1.89 1.44 1.66 1.12 .73 .93
Plcb4
KLA  ATP  ATP+KLA
 AK082509 0 day neonate cerebellum cDNA, RIKEN full-length enriched library, clone:C230058B11 product:unclassifiable, full insert sequence. [AK082509] KLA 1.06 1.03 .97 .98 1.02 1.01 .99
ATP .99 1.07 1.09 .95 .97 .97 1.02
KLA/ATP .98 1.00 1.03 .96 1.02 .91 .98
Plcb4
KLA  ATP  ATP+KLA
 NM_013829 phospholipase C, beta 4 (Plcb4), mRNA [NM_013829] KLA .88 .94 .81 .82 .81 .86 1.01
ATP 1.00 1.01 .92 .93 .88 .85 .89
KLA/ATP .97 .94 .78 .80 .78 .86 .97
Plcd1
KLA  ATP  ATP+KLA
 NM_019676 phospholipase C, delta 1 (Plcd1), mRNA [NM_019676] KLA 2.80 2.76 2.50 2.05 1.09 .66 1.49
ATP .93 .94 1.22 1.10 .99 1.35 .50
KLA/ATP 2.55 2.84 3.38 2.74 1.98 1.32 .80
Plcd3
KLA  ATP  ATP+KLA
 NM_152813 phospholipase C, delta 3 (Plcd3), mRNA [NM_152813] KLA .58 .56 .49 .61 .70 .74 .87
ATP .98 1.07 .91 .92 .80 .96 1.23
KLA/ATP .58 .55 .59 .61 .75 1.03 1.68
Plcd4
KLA  ATP  ATP+KLA
 NM_148937 phospholipase C, delta 4 (Plcd4), transcript variant 2, mRNA [NM_148937] KLA 1.04 .99 1.00 .99 .95 1.02 1.06
ATP .99 .98 .99 1.13 1.00 1.02 1.04
KLA/ATP 1.04 1.01 1.00 .97 1.10 .99 1.02
Plce1
KLA  ATP  ATP+KLA
 AK035546 adult male urinary bladder cDNA, RIKEN full-length enriched library, clone:9530064F18 product:PANCREAS-ENRICHED PHOSPHOLIPASE C homolog [Homo sapiens], full insert sequence. [AK035546] KLA .99 1.08 1.03 1.00 1.06 1.04 .97
ATP 1.04 1.01 1.02 1.01 .96 1.01 1.06
KLA/ATP .98 .98 .93 1.02 .95 .93 .97
Plce1
KLA  ATP  ATP+KLA
 BC025027 phospholipase C, epsilon 1, mRNA (cDNA clone IMAGE:4948638), with apparent retained intron. [BC025027] KLA 1.07 1.12 1.04 1.10 1.07 1.04 1.04
ATP 1.00 .96 1.06 .99 .98 .96 1.01
KLA/ATP 1.21 1.06 1.13 1.09 1.00 1.08 1.14
Plce1
KLA  ATP  ATP+KLA
 NM_019588 phospholipase C, epsilon 1 (Plce1), mRNA [NM_019588] KLA .98 1.03 .99 .96 1.01 1.04 .96
ATP .98 .99 1.02 1.13 .99 1.01 1.00
KLA/ATP .97 1.11 1.00 1.07 .93 1.06 .99
Plcg2
KLA  ATP  ATP+KLA
 NM_172285 phospholipase C, gamma 2 (Plcg2), mRNA [NM_172285] KLA .76 .74 .68 .66 .71 .92 .95
ATP .96 .90 .95 .87 .81 .79 .91
KLA/ATP .76 .71 .69 .62 .72 .78 .68
Plcz1
KLA  ATP  ATP+KLA
 NM_054066 phospholipase C, zeta 1 (Plcz1), mRNA [NM_054066] KLA 1.02 .99 .97 1.04 .98 .95 .98
ATP 1.01 1.03 1.03 .98 .97 1.00 1.04
KLA/ATP 1.02 1.04 1.03 .99 1.01 1.00 1.01
Prkca
KLA  ATP  ATP+KLA
 NM_011101 protein kinase C, alpha (Prkca), mRNA [NM_011101] KLA 1.00 .96 .94 .95 .95 .89 .96
ATP 1.00 1.03 .91 .94 .82 .87 1.13
KLA/ATP 1.02 .95 .91 .86 .78 .84 .94
Prkcb1
KLA  ATP  ATP+KLA
 NM_008855 protein kinase C, beta 1 (Prkcb1), mRNA [NM_008855] KLA .92 .95 .93 .78 .77 1.08 1.83
ATP 1.03 1.12 1.09 1.23 .90 2.08 .96
KLA/ATP .98 .99 .82 .89 .62 1.01 1.08
Prkcc
KLA  ATP  ATP+KLA
 NM_011102 protein kinase C, gamma (Prkcc), mRNA [NM_011102] KLA 1.02 1.04 1.11 1.04 .96 1.02 1.05
ATP .98 .98 1.05 1.03 1.08 .96 .95
KLA/ATP 1.21 1.16 1.09 1.07 1.04 .98 .93
Pten
KLA  ATP  ATP+KLA
 NM_008960 phosphatase and tensin homolog (Pten), mRNA [NM_008960] KLA .79 .73 .61 .59 .56 .70 1.00
ATP 1.04 1.11 1.07 1.12 1.03 1.38 .83
KLA/ATP .75 .69 .60 .74 .93 1.09 1.24
RP23-136
K12.4
KLA  ATP  ATP+KLA
 NM_008916 putative phosphatase (Pps), mRNA [NM_008916] KLA 1.35 1.47 1.81 1.90 2.21 2.28 1.37
ATP 1.00 1.04 1.03 1.11 .86 .77 1.25
KLA/ATP 1.45 1.56 1.59 1.74 1.57 1.45 2.55
Synj1
KLA  ATP  ATP+KLA
 AK080946 4 days neonate male adipose cDNA, RIKEN full-length enriched library, clone:B430216F19 product:SYNAPTOJANIN 1 (EC 3.1.3.56) (SYNAPTIC INOSITOL-1,4,5-TRISPHOSPHATE 5- PHOSPHATASE 1) homolog [Rattus norvegicus], full insert sequence. [AK080 KLA 2.98 2.90 3.08 3.32 2.29 1.91 1.44
ATP .88 .86 1.58 1.20 1.53 2.26 1.97
KLA/ATP 2.79 3.22 4.30 2.74 2.82 2.28 2.35
Synj1
KLA  ATP  ATP+KLA
 XM_001481287 gb|PREDICTED: Mus musculus synaptojanin 1 (Synj1), mRNA [XM_001481287] KLA 3.23 3.00 3.78 3.44 2.82 2.78 1.56
ATP .97 .86 1.21 .59 1.04 1.34 1.07
KLA/ATP 3.33 3.04 4.28 1.80 2.61 2.79 1.99
Synj2
KLA  ATP  ATP+KLA
 AK014584 0 day neonate skin cDNA, RIKEN full-length enriched library, clone:4632417B14 product:synaptojanin 2, full insert sequence. [AK014584] KLA .87 .82 .75 .78 .71 .96 1.05
ATP .95 1.11 1.78 1.18 .95 1.08 1.89
KLA/ATP .68 .74 .89 .83 .73 .73 1.14
Synj2
KLA  ATP  ATP+KLA
 NM_001113353 synaptojanin 2 (Synj2), transcript variant 1, mRNA [NM_001113353] KLA .45 .41 .40 .44 .48 .65 .72
ATP 1.06 1.04 1.10 .99 .60 .76 1.67
KLA/ATP .44 .41 .45 .46 .46 .52 1.15
Synj2
KLA  ATP  ATP+KLA
 NM_011523 synaptojanin 2 (Synj2), transcript variant 3, mRNA [NM_011523] KLA .62 .59 .54 .64 .49 .57 .57
ATP .95 .90 .94 .78 .61 .60 .78
KLA/ATP .56 .59 .63 .56 .56 .68 .59