Microarray data for Acat1: fold-change ratios

Bone marrow-derived macrophage cells treated with Kdo2-Lipid A (KLA) and ATP

Gene Time course graph Description Treatment 15min 30min 1h 2h 4h 8h 20h
Acat1
KLA  ATP  ATP+KLA
 acetyl-Coenzyme A acetyltransferase 1 (Acat1), nuclear gene encoding mitochondrial protein, mRNA [NM_144784] KLA 1.04 .99 .95 .99 .81 .83 .51
 ATP .89 .88 1.21 .99 .67 .36 .47
 ATP+KLA .86 .97 1.18 .90 .64 .42 .35

Bone marrow-derived macrophage cells treated with 25-hydroxy-cholesterol +/- lipid-depleted media containing compactin

Gene Time course graph Description Treatment 30min 1h 2h 4h 8h 12h 24h
Acat1
25OHC/Ctl - treatment with 25-OHC / no treatment
25-OHC*/* - lipid depleted media containing compactin and treatment with 25-OHC / lipid depleted media containing compactin only
acetyl-Coenzyme A acetyltransferase 1 (Acat1), nuclear gene encoding mitochondrial protein, mRNA [NM_144784] 25OHC/Ctl (?) .99 1.00 .97 1.10 1.02 .85 .76
 25-OHC*/* (?) .94 1.05 .79 1.16 1.06 .98 .93
 
 

Thioglycolate-elicited macrophage cells treated with Kdo2-Lipid A (KLA) and compactin

Gene Time course graph Description Treatment 30min 1h 2h 4h 8h 12h 24h
Acat1
KLA  Compactin  Compactin+KLA
 acetyl-Coenzyme A acetyltransferase 1 KLA .98 .93 .98 1.05 1.08 .97 1.04
 Compactin 1.07 1.03 1.00 1.00 1.06 .99 .91
 Compactin+KLA 1.05 1.03 1.03 1.01 .98 .97 .96
Acat1
KLA  Compactin  Compactin+KLA
 acetyl-Coenzyme A acetyltransferase 1 (Acat1), nuclear gene encoding mitochondrial protein, mRNA [NM_144784] KLA 1.07 1.03 1.04 .80 .74 .78 .95
 Compactin 1.03 .99 1.02 .98 1.05 1.05 1.01
 Compactin+KLA 1.07 1.07 1.02 .82 .80 .77 .92

RAW 264.7 cells treated with Kdo2-Lipid A (KLA) and compactin

Gene Time course graph Description Treatment 30min 1h 2h 4h 8h 12h 24h
Acat1
KLA  Compactin  Compactin+KLA
 acetyl-Coenzyme A acetyltransferase 1 KLA .99 1.04 .99 .95 1.03 .91 .97
 Compactin 1.04 1.04 .96 .99 1.10 .98 1.05
 Compactin+KLA 1.01 1.04 .96 .95 .98 1.04 .97
Acat1
KLA  Compactin  Compactin+KLA
 acetyl-Coenzyme A acetyltransferase 1 (Acat1), nuclear gene encoding mitochondrial protein, mRNA [NM_144784] KLA 1.06 1.00 1.14 1.12 .89 .89 .65
 Compactin 1.13 1.13 1.17 1.19 .98 1.08 1.04
 Compactin+KLA 1.21 1.04 1.19 1.10 .95 .85 .70