Microarray data for Acat2: fold-change ratios

Bone marrow-derived macrophage cells treated with Kdo2-Lipid A (KLA) and ATP

Gene Time course graph Description Treatment 15min 30min 1h 2h 4h 8h 20h
Acat2
KLA  ATP  ATP+KLA
 acetyl-Coenzyme A acetyltransferase 2 (Acat2), mRNA [NM_009338] KLA 1.14 1.13 1.22 1.29 1.10 .93 .81
 ATP 1.04 1.05 1.16 1.35 1.20 1.53 1.16
 ATP+KLA 1.19 1.19 1.41 1.29 1.13 .92 .71

Bone marrow-derived macrophage cells treated with 25-hydroxy-cholesterol +/- lipid-depleted media containing compactin

Gene Time course graph Description Treatment 30min 1h 2h 4h 8h 12h 24h
Acat2
25OHC/Ctl - treatment with 25-OHC / no treatment
25-OHC*/* - lipid depleted media containing compactin and treatment with 25-OHC / lipid depleted media containing compactin only
acetyl-Coenzyme A acetyltransferase 2 (Acat2), mRNA [NM_009338] 25OHC/Ctl (?) .97 .99 .86 .75 .72 .68 .54
 25-OHC*/* (?) 1.02 .84 .76 .44 .33 .31 .36
 
 

Thioglycolate-elicited macrophage cells treated with Kdo2-Lipid A (KLA) and compactin

Gene Time course graph Description Treatment 30min 1h 2h 4h 8h 12h 24h
Acat2
KLA  Compactin  Compactin+KLA
 acetyl-Coenzyme A acetyltransferase 2 (Acat2), mRNA [NM_009338] KLA 1.00 1.04 1.50 1.35 1.24 1.30 1.30
 Compactin 1.08 .99 .96 1.11 1.02 1.23 1.09
 Compactin+KLA .99 1.11 1.44 1.43 1.62 1.50 1.27

RAW 264.7 cells treated with Kdo2-Lipid A (KLA) and compactin

Gene Time course graph Description Treatment 30min 1h 2h 4h 8h 12h 24h
Acat2
KLA  Compactin  Compactin+KLA
 acetyl-Coenzyme A acetyltransferase 2 (Acat2), mRNA [NM_009338] KLA .99 .96 .94 1.00 .74 .88 .98
 Compactin .99 1.06 1.19 1.15 1.10 1.09 .92
 Compactin+KLA .94 1.03 1.02 1.02 .87 .88 .96