Microarray data for Acot2: fold-change ratios

Bone marrow-derived macrophage cells treated with Kdo2-Lipid A (KLA) and ATP

Gene Time course graph Description Treatment 15min 30min 1h 2h 4h 8h 20h
Acot2
KLA  ATP  ATP+KLA
acyl-CoA thioesterase 2 (Acot2), nuclear gene encoding mitochondrial protein, mRNA [NM_134188] KLA .46 .49 .37 .43 .34 .37 .53
 ATP 1.02 1.15 .87 .99 .54 .37 .96
 ATP+KLA .51 .46 .44 .49 .36 .34 .49

Bone marrow-derived macrophage cells treated with 25-hydroxy-cholesterol +/- lipid-depleted media containing compactin

Gene Time course graph Description Treatment 30min 1h 2h 4h 8h 12h 24h
Acot2
25OHC/Ctl - treatment with 25-OHC / no treatment
25-OHC*/* - lipid depleted media containing compactin and treatment with 25-OHC / lipid depleted media containing compactin only
acyl-CoA thioesterase 2 (Acot2), nuclear gene encoding mitochondrial protein, mRNA [NM_134188] 25OHC/Ctl (?) 1.04 .92 1.09 .93 .99 1.20 1.20
 25-OHC*/* (?) 1.20 .92 .82 .90 1.22 1.42 1.50
 
 

Thioglycolate-elicited macrophage cells treated with Kdo2-Lipid A (KLA) and compactin

Gene Time course graph Description Treatment 30min 1h 2h 4h 8h 12h 24h
Acot2
KLA  Compactin  Compactin+KLA
acyl-CoA thioesterase 2 (Acot2), nuclear gene encoding mitochondrial protein, mRNA [NM_134188] KLA 1.05 .90 .70 .68 .66 .63 .61
 Compactin 1.02 1.06 .99 1.02 .95 1.00 .99
 Compactin+KLA 1.08 1.01 .75 .69 .62 .68 .64

RAW 264.7 cells treated with Kdo2-Lipid A (KLA) and compactin

Gene Time course graph Description Treatment 30min 1h 2h 4h 8h 12h 24h
Acot2
KLA  Compactin  Compactin+KLA
acyl-CoA thioesterase 2 (Acot2), nuclear gene encoding mitochondrial protein, mRNA [NM_134188] KLA .97 .98 .93 .79 .88 .94 .75
 Compactin 1.03 1.06 1.07 1.10 1.09 .83 1.70
 Compactin+KLA 1.01 .98 .92 .82 .83 .95 .57