Microarray data for Agpat4: fold-change ratios

Bone marrow-derived macrophage cells treated with Kdo2-Lipid A (KLA) and ATP

Gene Time course graph Description Treatment 15min 30min 1h 2h 4h 8h 20h
Agpat4
KLA  ATP  ATP+KLA
 1-acylglycerol-3-phosphate O-acyltransferase 4 (lysophosphatidic acid acyltransferase, delta) (Agpat4), mRNA [NM_026644] KLA 1.37 1.26 1.06 1.10 .98 1.29 1.77
 ATP 1.05 .95 1.02 1.26 1.86 3.88 2.42
 ATP+KLA 1.38 1.32 1.44 1.22 1.29 2.06 5.07

Bone marrow-derived macrophage cells treated with 25-hydroxy-cholesterol +/- lipid-depleted media containing compactin

Gene Time course graph Description Treatment 30min 1h 2h 4h 8h 12h 24h
Agpat4
25OHC/Ctl - treatment with 25-OHC / no treatment
25-OHC*/* - lipid depleted media containing compactin and treatment with 25-OHC / lipid depleted media containing compactin only
1-acylglycerol-3-phosphate O-acyltransferase 4 (lysophosphatidic acid acyltransferase, delta) (Agpat4), mRNA [NM_026644] 25OHC/Ctl (?) 1.04 1.08 .95 1.33 1.22 1.20 1.45
 25-OHC*/* (?) 1.03 1.11 1.02 1.06 .91 .91 1.04
 
 

Thioglycolate-elicited macrophage cells treated with Kdo2-Lipid A (KLA) and compactin

Gene Time course graph Description Treatment 30min 1h 2h 4h 8h 12h 24h
Agpat4
KLA  Compactin  Compactin+KLA
 1-acylglycerol-3-phosphate O-acyltransferase 4 (lysophosphatidic acid acyltransferase, delta) (Agpat4), mRNA [NM_026644] KLA .99 .88 1.01 .98 1.17 1.20 1.56
 Compactin 1.06 .98 .97 .99 1.10 1.13 .93
 Compactin+KLA .88 1.23 1.39 .91 1.01 1.48 1.63

RAW 264.7 cells treated with Kdo2-Lipid A (KLA) and compactin

Gene Time course graph Description Treatment 30min 1h 2h 4h 8h 12h 24h
Agpat4
KLA  Compactin  Compactin+KLA
 1-acylglycerol-3-phosphate O-acyltransferase 4 (lysophosphatidic acid acyltransferase, delta) (Agpat4), mRNA [NM_026644] KLA .91 1.26 2.19 3.31 2.93 2.15 3.15
 Compactin .90 .96 .77 .74 .89 1.19 1.85
 Compactin+KLA .94 1.06 2.13 2.99 1.78 2.75 3.65