Microarray data for Agpat6: fold-change ratios

Bone marrow-derived macrophage cells treated with Kdo2-Lipid A (KLA) and ATP

Gene Time course graph Description Treatment 15min 30min 1h 2h 4h 8h 20h
Agpat6
KLA  ATP  ATP+KLA
 1-acylglycerol-3-phosphate O-acyltransferase 6 (lysophosphatidic acid acyltransferase, zeta) (Agpat6), mRNA [NM_018743] KLA 1.14 1.08 1.21 1.15 1.17 1.25 1.50
 ATP 1.05 1.02 .91 .91 1.11 1.42 1.26
 ATP+KLA 1.16 1.17 .96 .87 1.00 1.40 1.35

Bone marrow-derived macrophage cells treated with 25-hydroxy-cholesterol +/- lipid-depleted media containing compactin

Gene Time course graph Description Treatment 30min 1h 2h 4h 8h 12h 24h
Agpat6
25OHC/Ctl - treatment with 25-OHC / no treatment
25-OHC*/* - lipid depleted media containing compactin and treatment with 25-OHC / lipid depleted media containing compactin only
1-acylglycerol-3-phosphate O-acyltransferase 6 (lysophosphatidic acid acyltransferase, zeta) (Agpat6), mRNA [NM_018743] 25OHC/Ctl (?) .99 .93 1.06 1.00 .99 1.01 1.08
 25-OHC*/* (?) 1.01 .96 1.19 1.01 1.01 1.03 1.06
 
 

Thioglycolate-elicited macrophage cells treated with Kdo2-Lipid A (KLA) and compactin

Gene Time course graph Description Treatment 30min 1h 2h 4h 8h 12h 24h
Agpat6
KLA  Compactin  Compactin+KLA
 1-acylglycerol-3-phosphate O-acyltransferase 6 (lysophosphatidic acid acyltransferase, zeta) (Agpat6), mRNA [NM_018743] KLA .98 .93 1.15 1.33 1.41 1.46 1.43
 Compactin 1.03 .99 .97 1.03 .98 1.00 1.00
 Compactin+KLA .95 .96 1.21 1.27 1.39 1.46 1.52

RAW 264.7 cells treated with Kdo2-Lipid A (KLA) and compactin

Gene Time course graph Description Treatment 30min 1h 2h 4h 8h 12h 24h
Agpat6
KLA  Compactin  Compactin+KLA
 1-acylglycerol-3-phosphate O-acyltransferase 6 (lysophosphatidic acid acyltransferase, zeta) (Agpat6), mRNA [NM_018743] KLA .90 .91 .88 .85 .83 .97 1.01
 Compactin .97 .89 .88 .89 .89 .91 .85
 Compactin+KLA .89 .96 .92 .74 .95 .96 .93