Microarray data for Cds1: fold-change ratios

Bone marrow-derived macrophage cells treated with Kdo2-Lipid A (KLA) and ATP

Gene Time course graph Description Treatment 15min 30min 1h 2h 4h 8h 20h
Cds1
KLA  ATP  ATP+KLA
 CDP-diacylglycerol synthase 1 (Cds1), mRNA [NM_173370] KLA 2.81 2.96 3.63 3.43 3.28 1.96 .97
 ATP 1.08 1.05 .86 .90 .78 .83 1.17
 ATP+KLA 2.84 2.92 2.34 2.04 1.61 1.01 .98

Bone marrow-derived macrophage cells treated with 25-hydroxy-cholesterol +/- lipid-depleted media containing compactin

Gene Time course graph Description Treatment 30min 1h 2h 4h 8h 12h 24h
Cds1
25OHC/Ctl - treatment with 25-OHC / no treatment
25-OHC*/* - lipid depleted media containing compactin and treatment with 25-OHC / lipid depleted media containing compactin only
CDP-diacylglycerol synthase 1 (Cds1), mRNA [NM_173370] 25OHC/Ctl (?) .97 .90 1.02 1.00 .92 .84 .91
 25-OHC*/* (?) 1.05 1.00 1.13 .93 .89 .85 .75
 
 

Thioglycolate-elicited macrophage cells treated with Kdo2-Lipid A (KLA) and compactin

Gene Time course graph Description Treatment 30min 1h 2h 4h 8h 12h 24h
Cds1
KLA  Compactin  Compactin+KLA
 CDP-diacylglycerol synthase 1 (Cds1), mRNA [NM_173370] KLA .94 1.10 1.48 2.85 2.01 1.32 1.16
 Compactin 1.00 1.09 .97 1.10 1.04 1.07 1.06
 Compactin+KLA .99 1.06 1.43 2.98 2.01 1.32 1.24

RAW 264.7 cells treated with Kdo2-Lipid A (KLA) and compactin

Gene Time course graph Description Treatment 30min 1h 2h 4h 8h 12h 24h
Cds1
KLA  Compactin  Compactin+KLA
 CDP-diacylglycerol synthase 1 (Cds1), mRNA [NM_173370] KLA .91 .95 .96 1.20 1.17 1.05 1.22
 Compactin .95 .99 .97 .96 .91 .94 .92
 Compactin+KLA .99 .93 1.03 1.13 1.36 1.13 1.17