Microarray data for Dhcr24: fold-change ratios

Bone marrow-derived macrophage cells treated with Kdo2-Lipid A (KLA) and ATP

Gene Time course graph Description Treatment 15min 30min 1h 2h 4h 8h 20h
Dhcr24
KLA  ATP  ATP+KLA
 24-dehydrocholesterol reductase (Dhcr24), mRNA [NM_053272] KLA .50 .50 .44 .42 .35 .28 .36
 ATP 1.09 1.12 1.01 1.09 .72 .43 1.05
 ATP+KLA .51 .54 .46 .54 .33 .22 .18

Bone marrow-derived macrophage cells treated with 25-hydroxy-cholesterol +/- lipid-depleted media containing compactin

Gene Time course graph Description Treatment 30min 1h 2h 4h 8h 12h 24h
Dhcr24
25OHC/Ctl - treatment with 25-OHC / no treatment
25-OHC*/* - lipid depleted media containing compactin and treatment with 25-OHC / lipid depleted media containing compactin only
24-dehydrocholesterol reductase (Dhcr24), mRNA [NM_053272] 25OHC/Ctl (?) .91 .86 .83 .42 .17 .17 .17
 25-OHC*/* (?) 1.00 .87 1.00 .29 .10 .08 .08
 
 

Thioglycolate-elicited macrophage cells treated with Kdo2-Lipid A (KLA) and compactin

Gene Time course graph Description Treatment 30min 1h 2h 4h 8h 12h 24h
Dhcr24
KLA  Compactin  Compactin+KLA
 24-dehydrocholesterol reductase (Dhcr24), mRNA [NM_053272] KLA .85 1.00 1.15 .88 .66 .51 .43
 Compactin .98 1.12 1.03 1.07 1.14 1.23 1.07
 Compactin+KLA .87 1.07 1.25 1.02 .78 .60 .55

RAW 264.7 cells treated with Kdo2-Lipid A (KLA) and compactin

Gene Time course graph Description Treatment 30min 1h 2h 4h 8h 12h 24h
Dhcr24
KLA  Compactin  Compactin+KLA
 24-dehydrocholesterol reductase (Dhcr24), mRNA [NM_053272] KLA 1.09 .93 .92 .50 .53 .49 .24
 Compactin 1.00 1.04 1.02 .98 1.06 1.16 .92
 Compactin+KLA 1.04 .96 1.04 .50 .50 .41 .30