Microarray data for Hmgcr: fold-change ratios

Bone marrow-derived macrophage cells treated with Kdo2-Lipid A (KLA) and ATP

Gene Time course graph Description Treatment 15min 30min 1h 2h 4h 8h 20h
Hmgcr
KLA  ATP  ATP+KLA
 3-hydroxy-3-methylglutaryl-Coenzyme A reductase (Hmgcr), mRNA [NM_008255] KLA 2.15 2.09 2.02 1.44 1.13 .88 1.02
 ATP 1.05 1.16 1.43 1.53 1.83 2.60 1.87
 ATP+KLA 2.16 2.23 1.99 1.81 1.34 1.81 1.79

Bone marrow-derived macrophage cells treated with 25-hydroxy-cholesterol +/- lipid-depleted media containing compactin

Gene Time course graph Description Treatment 30min 1h 2h 4h 8h 12h 24h
Hmgcr
25OHC/Ctl - treatment with 25-OHC / no treatment
25-OHC*/* - lipid depleted media containing compactin and treatment with 25-OHC / lipid depleted media containing compactin only
3-hydroxy-3-methylglutaryl-Coenzyme A reductase (Hmgcr), mRNA [NM_008255] 25OHC/Ctl (?) .94 .84 .54 .52 .53 .58 .54
 25-OHC*/* (?) 1.01 .80 .34 .24 .24 .26 .27
 
 

Thioglycolate-elicited macrophage cells treated with Kdo2-Lipid A (KLA) and compactin

Gene Time course graph Description Treatment 30min 1h 2h 4h 8h 12h 24h
Hmgcr
KLA  Compactin  Compactin+KLA
 3-hydroxy-3-methylglutaryl-Coenzyme A reductase (Hmgcr), mRNA [NM_008255] KLA 1.06 1.48 1.44 2.07 1.64 1.22 .96
 Compactin .99 .97 1.12 1.05 1.10 1.10 1.02
 Compactin+KLA .97 1.49 1.57 2.26 1.88 1.28 1.06

RAW 264.7 cells treated with Kdo2-Lipid A (KLA) and compactin

Gene Time course graph Description Treatment 30min 1h 2h 4h 8h 12h 24h
Hmgcr
KLA  Compactin  Compactin+KLA
 3-hydroxy-3-methylglutaryl-Coenzyme A reductase (Hmgcr), mRNA [NM_008255] KLA 1.15 1.47 1.66 1.32 1.28 1.28 .96
 Compactin 1.09 1.04 1.04 1.14 .99 1.06 .88
 Compactin+KLA 1.21 1.46 1.76 1.44 1.44 1.45 1.03