Microarray data for Lass2: fold-change ratios

Bone marrow-derived macrophage cells treated with Kdo2-Lipid A (KLA) and ATP

Gene Time course graph Description Treatment 15min 30min 1h 2h 4h 8h 20h
Lass2
KLA  ATP  ATP+KLA
 LAG1 homolog, ceramide synthase 2 (Lass2), mRNA [NM_029789] KLA .79 .81 .81 .68 .72 .72 1.08
 ATP 1.02 1.11 .95 1.07 .94 .70 1.25
 ATP+KLA .86 .86 .62 .78 .64 .63 .97

Bone marrow-derived macrophage cells treated with 25-hydroxy-cholesterol +/- lipid-depleted media containing compactin

Gene Time course graph Description Treatment 30min 1h 2h 4h 8h 12h 24h
Lass2
25OHC/Ctl - treatment with 25-OHC / no treatment
25-OHC*/* - lipid depleted media containing compactin and treatment with 25-OHC / lipid depleted media containing compactin only
LAG1 homolog, ceramide synthase 2 (Lass2), mRNA [NM_029789] 25OHC/Ctl (?) .95 .91 1.03 .89 1.03 1.08 1.12
 25-OHC*/* (?) .98 .94 1.03 .91 1.09 1.13 .94
 
 

Thioglycolate-elicited macrophage cells treated with Kdo2-Lipid A (KLA) and compactin

Gene Time course graph Description Treatment 30min 1h 2h 4h 8h 12h 24h
Lass2
KLA  Compactin  Compactin+KLA
 LAG1 homolog, ceramide synthase 2 (Lass2), mRNA [NM_029789] KLA .93 .95 .99 .98 .98 1.11 .96
 Compactin 1.00 .99 1.00 1.04 .98 .99 .99
 Compactin+KLA 1.01 .91 1.05 .95 1.05 1.06 .90

RAW 264.7 cells treated with Kdo2-Lipid A (KLA) and compactin

Gene Time course graph Description Treatment 30min 1h 2h 4h 8h 12h 24h
Lass2
KLA  Compactin  Compactin+KLA
 LAG1 homolog, ceramide synthase 2 (Lass2), mRNA [NM_029789] KLA .95 .99 1.03 1.00 .98 1.22 1.14
 Compactin 1.06 1.03 1.02 1.01 .95 1.18 1.11
 Compactin+KLA 1.05 .98 .98 .94 1.12 1.45 1.24