Microarray data for Lass5: fold-change ratios

Bone marrow-derived macrophage cells treated with Kdo2-Lipid A (KLA) and ATP

Gene Time course graph Description Treatment 15min 30min 1h 2h 4h 8h 20h
Lass5
KLA  ATP  ATP+KLA
 LAG1 homolog, ceramide synthase 5 (Lass5), mRNA [NM_028015] KLA .62 .60 .53 .42 .37 .34 .66
 ATP 1.05 1.15 1.02 1.21 .85 .53 .90
 ATP+KLA .68 .64 .53 .54 .39 .37 .42

Bone marrow-derived macrophage cells treated with 25-hydroxy-cholesterol +/- lipid-depleted media containing compactin

Gene Time course graph Description Treatment 30min 1h 2h 4h 8h 12h 24h
Lass5
25OHC/Ctl - treatment with 25-OHC / no treatment
25-OHC*/* - lipid depleted media containing compactin and treatment with 25-OHC / lipid depleted media containing compactin only
LAG1 homolog, ceramide synthase 5 (Lass5), mRNA [NM_028015] 25OHC/Ctl (?) .94 .95 1.01 .85 .87 .93 1.22
 25-OHC*/* (?) .98 .95 1.10 .84 .94 .90 .91
 
 

Thioglycolate-elicited macrophage cells treated with Kdo2-Lipid A (KLA) and compactin

Gene Time course graph Description Treatment 30min 1h 2h 4h 8h 12h 24h
Lass5
KLA  Compactin  Compactin+KLA
 LAG1 homolog, ceramide synthase 5 (Lass5), mRNA [NM_028015] KLA .98 1.03 .99 .67 .40 .45 .61
 Compactin 1.04 .96 1.00 .95 .95 .98 .93
 Compactin+KLA 1.03 .98 .90 .63 .44 .47 .63

RAW 264.7 cells treated with Kdo2-Lipid A (KLA) and compactin

Gene Time course graph Description Treatment 30min 1h 2h 4h 8h 12h 24h
Lass5
KLA  Compactin  Compactin+KLA
 LAG1 homolog, ceramide synthase 5 (Lass5), mRNA [NM_028015] KLA 1.00 1.06 1.13 1.15 1.03 .81 .64
 Compactin 1.12 1.08 1.00 1.15 1.16 1.11 1.14
 Compactin+KLA 1.14 1.06 1.15 1.05 1.04 .96 .66