Microarray data for Lss: fold-change ratios

Bone marrow-derived macrophage cells treated with Kdo2-Lipid A (KLA) and ATP

Gene Time course graph Description Treatment 15min 30min 1h 2h 4h 8h 20h
Lss
KLA  ATP  ATP+KLA
 adult male brain UNDEFINED_CELL_LINE cDNA, RIKEN full-length enriched library, clone:M5C1106O04 product:lanosterol synthase, full insert sequence [AK147680] KLA .52 .46 .46 .47 .49 .43 .44
 ATP .93 .92 1.44 .97 .55 .39 .46
 ATP+KLA .46 .45 .56 .47 .44 .32 .15
Lss
KLA  ATP  ATP+KLA
 lanosterol synthase (Lss), mRNA [NM_146006] KLA .77 .80 .87 .80 .90 .70 .80
 ATP 1.04 1.09 1.03 1.18 .73 .67 1.63
 ATP+KLA .79 .89 .87 .88 .57 .46 .43

Bone marrow-derived macrophage cells treated with 25-hydroxy-cholesterol +/- lipid-depleted media containing compactin

Gene Time course graph Description Treatment 30min 1h 2h 4h 8h 12h 24h
Lss
25OHC/Ctl - treatment with 25-OHC / no treatment
25-OHC*/* - lipid depleted media containing compactin and treatment with 25-OHC / lipid depleted media containing compactin only
adult male brain UNDEFINED_CELL_LINE cDNA, RIKEN full-length enriched library, clone:M5C1106O04 product:lanosterol synthase, full insert sequence [AK147680] 25OHC/Ctl (?) .97 .94 .68 .51 .49 .46 .33
 25-OHC*/* (?) .94 .76 .50 .22 .17 .17 .16
 
 
Lss
25OHC/Ctl - treatment with 25-OHC / no treatment
25-OHC*/* - lipid depleted media containing compactin and treatment with 25-OHC / lipid depleted media containing compactin only
lanosterol synthase (Lss), mRNA [NM_146006] 25OHC/Ctl (?) .94 .85 .81 .56 .43 .44 .35
 25-OHC*/* (?) .95 .87 .79 .29 .16 .17 .17
 
 

Thioglycolate-elicited macrophage cells treated with Kdo2-Lipid A (KLA) and compactin

Gene Time course graph Description Treatment 30min 1h 2h 4h 8h 12h 24h
Lss
KLA  Compactin  Compactin+KLA
 adult male brain UNDEFINED_CELL_LINE cDNA, RIKEN full-length enriched library, clone:M5C1106O04 product:lanosterol synthase, full insert sequence [AK147680] KLA 1.00 .73 .60 .51 .50 .53 .73
 Compactin .97 .98 1.08 .99 1.13 1.09 1.03
 Compactin+KLA 1.09 .79 .58 .57 .57 .65 .77
Lss
KLA  Compactin  Compactin+KLA
 lanosterol synthase (Lss), mRNA [NM_146006] KLA .93 1.00 .86 .84 .84 .88 1.11
 Compactin .97 .98 1.33 1.09 1.04 1.11 1.12
 Compactin+KLA 1.02 .98 .89 .93 1.11 1.09 1.21

RAW 264.7 cells treated with Kdo2-Lipid A (KLA) and compactin

Gene Time course graph Description Treatment 30min 1h 2h 4h 8h 12h 24h
Lss
KLA  Compactin  Compactin+KLA
 adult male brain UNDEFINED_CELL_LINE cDNA, RIKEN full-length enriched library, clone:M5C1106O04 product:lanosterol synthase, full insert sequence [AK147680] KLA 1.11 .91 .72 .56 .68 .73 .55
 Compactin 1.13 1.08 1.22 1.23 1.18 .90 .76
 Compactin+KLA 1.15 .91 .80 .75 .67 .53 .48
Lss
KLA  Compactin  Compactin+KLA
 lanosterol synthase (Lss), mRNA [NM_146006] KLA 1.03 .99 1.00 .77 1.03 1.22 1.09
 Compactin 1.00 1.00 .96 1.05 1.17 1.10 .97
 Compactin+KLA 1.01 .93 1.11 .89 .98 1.06 1.14