Microarray data for Mvd: fold-change ratios

Bone marrow-derived macrophage cells treated with Kdo2-Lipid A (KLA) and ATP

Gene Time course graph Description Treatment 15min 30min 1h 2h 4h 8h 20h
Mvd
KLA  ATP  ATP+KLA
 mevalonate (diphospho) decarboxylase (Mvd), mRNA [NM_138656] KLA .53 .53 .53 .53 .54 .48 .81
 ATP .95 .97 1.05 1.29 1.06 .87 1.80
 ATP+KLA .54 .57 .60 .73 .77 .56 .47

Bone marrow-derived macrophage cells treated with 25-hydroxy-cholesterol +/- lipid-depleted media containing compactin

Gene Time course graph Description Treatment 30min 1h 2h 4h 8h 12h 24h
Mvd
25OHC/Ctl - treatment with 25-OHC / no treatment
25-OHC*/* - lipid depleted media containing compactin and treatment with 25-OHC / lipid depleted media containing compactin only
mevalonate (diphospho) decarboxylase (Mvd), mRNA [NM_138656] 25OHC/Ctl (?) 1.00 .86 .72 .41 .35 .35 .31
 25-OHC*/* (?) .94 .85 .85 .19 .14 .13 .13
 
 

Thioglycolate-elicited macrophage cells treated with Kdo2-Lipid A (KLA) and compactin

Gene Time course graph Description Treatment 30min 1h 2h 4h 8h 12h 24h
Mvd
KLA  Compactin  Compactin+KLA
 mevalonate (diphospho) decarboxylase (Mvd), mRNA [NM_138656] KLA .93 .81 .52 .45 .62 .72 1.00
 Compactin 1.06 1.05 1.08 1.23 1.20 1.33 1.16
 Compactin+KLA 1.05 .89 .53 .56 .90 .90 1.32

RAW 264.7 cells treated with Kdo2-Lipid A (KLA) and compactin

Gene Time course graph Description Treatment 30min 1h 2h 4h 8h 12h 24h
Mvd
KLA  Compactin  Compactin+KLA
 mevalonate (diphospho) decarboxylase (Mvd), mRNA [NM_138656] KLA 1.07 1.01 .93 .60 .60 .82 .82
 Compactin 1.35 1.12 1.18 1.54 1.52 1.16 .89
 Compactin+KLA 1.17 .98 1.14 .84 .85 .84 .84