Microarray data for Mvk: fold-change ratios

Bone marrow-derived macrophage cells treated with Kdo2-Lipid A (KLA) and ATP

Gene Time course graph Description Treatment 15min 30min 1h 2h 4h 8h 20h
Mvk
KLA  ATP  ATP+KLA
 mevalonate kinase (Mvk), mRNA [NM_023556] KLA .87 .90 .89 .91 .90 .94 .99
 ATP .91 .79 .56 .59 .35 .47 1.40
 ATP+KLA .89 .74 .56 .61 .43 .43 .65

Bone marrow-derived macrophage cells treated with 25-hydroxy-cholesterol +/- lipid-depleted media containing compactin

Gene Time course graph Description Treatment 30min 1h 2h 4h 8h 12h 24h
Mvk
25OHC/Ctl - treatment with 25-OHC / no treatment
25-OHC*/* - lipid depleted media containing compactin and treatment with 25-OHC / lipid depleted media containing compactin only
mevalonate kinase (Mvk), mRNA [NM_023556] 25OHC/Ctl (?) 1.08 .90 .92 .66 .55 .64 .51
 25-OHC*/* (?) 1.03 .95 1.12 .39 .30 .27 .25
 
 

Thioglycolate-elicited macrophage cells treated with Kdo2-Lipid A (KLA) and compactin

Gene Time course graph Description Treatment 30min 1h 2h 4h 8h 12h 24h
Mvk
KLA  Compactin  Compactin+KLA
 mevalonate kinase (Mvk), mRNA [NM_023556] KLA 1.03 1.08 1.04 .81 .86 .89 1.09
 Compactin 1.07 1.14 1.06 1.12 1.07 1.17 1.10
 Compactin+KLA 1.06 1.04 .92 .90 1.05 1.03 1.21

RAW 264.7 cells treated with Kdo2-Lipid A (KLA) and compactin

Gene Time course graph Description Treatment 30min 1h 2h 4h 8h 12h 24h
Mvk
KLA  Compactin  Compactin+KLA
 mevalonate kinase (Mvk), mRNA [NM_023556] KLA 1.16 1.05 1.05 .93 .85 .99 .99
 Compactin 1.22 1.10 1.18 1.35 1.17 1.11 .89
 Compactin+KLA 1.26 1.04 1.02 .98 .98 .96 1.10