Microarray data for Pmvk: fold-change ratios

Bone marrow-derived macrophage cells treated with Kdo2-Lipid A (KLA) and ATP

Gene Time course graph Description Treatment 15min 30min 1h 2h 4h 8h 20h
Pmvk
KLA  ATP  ATP+KLA
 phosphomevalonate kinase (Pmvk), mRNA [NM_026784] KLA .89 .91 .96 .99 .92 .78 .88
 ATP 1.13 .98 1.07 1.10 .70 .51 1.19
 ATP+KLA .94 .95 1.06 .91 .80 .44 .53

Bone marrow-derived macrophage cells treated with 25-hydroxy-cholesterol +/- lipid-depleted media containing compactin

Gene Time course graph Description Treatment 30min 1h 2h 4h 8h 12h 24h
Pmvk
25OHC/Ctl - treatment with 25-OHC / no treatment
25-OHC*/* - lipid depleted media containing compactin and treatment with 25-OHC / lipid depleted media containing compactin only
phosphomevalonate kinase (Pmvk), mRNA [NM_026784] 25OHC/Ctl (?) .98 .99 .89 .68 .56 .54 .42
 25-OHC*/* (?) 1.02 .91 .74 .33 .20 .20 .20
 
 

Thioglycolate-elicited macrophage cells treated with Kdo2-Lipid A (KLA) and compactin

Gene Time course graph Description Treatment 30min 1h 2h 4h 8h 12h 24h
Pmvk
KLA  Compactin  Compactin+KLA
 phosphomevalonate kinase (Pmvk), mRNA [NM_026784] KLA 1.02 .89 .90 .82 .88 .69 .87
 Compactin 1.05 .95 1.03 1.04 1.07 1.15 1.15
 Compactin+KLA .95 .93 .93 .96 1.06 .84 1.04

RAW 264.7 cells treated with Kdo2-Lipid A (KLA) and compactin

Gene Time course graph Description Treatment 30min 1h 2h 4h 8h 12h 24h
Pmvk
KLA  Compactin  Compactin+KLA
 phosphomevalonate kinase (Pmvk), mRNA [NM_026784] KLA .96 .98 1.02 .87 .87 1.09 1.24
 Compactin 1.02 1.00 1.11 1.16 1.24 1.07 1.19
 Compactin+KLA .97 1.02 1.15 .98 1.14 1.35 1.61