Microarray data for Ptges: fold-change ratios

Bone marrow-derived macrophage cells treated with Kdo2-Lipid A (KLA) and ATP

Gene Time course graph Description Treatment 15min 30min 1h 2h 4h 8h 20h
Ptges
KLA  ATP  ATP+KLA
 prostaglandin E synthase (Ptges), mRNA [NM_022415] KLA 16.01 15.00 16.36 20.05 28.20 32.79 23.08
 ATP 1.00 1.03 1.44 2.27 10.67 30.61 17.52
 ATP+KLA 14.56 16.98 20.33 21.07 21.87 25.39 38.01

Bone marrow-derived macrophage cells treated with 25-hydroxy-cholesterol +/- lipid-depleted media containing compactin

Gene Time course graph Description Treatment 30min 1h 2h 4h 8h 12h 24h
Ptges
25OHC/Ctl - treatment with 25-OHC / no treatment
25-OHC*/* - lipid depleted media containing compactin and treatment with 25-OHC / lipid depleted media containing compactin only
prostaglandin E synthase (Ptges), mRNA [NM_022415] 25OHC/Ctl (?) .98 1.07 1.09 1.16 1.06 1.18 1.51
 25-OHC*/* (?) 1.07 .94 1.33 .85 .96 1.15 1.35
 
 

Thioglycolate-elicited macrophage cells treated with Kdo2-Lipid A (KLA) and compactin

Gene Time course graph Description Treatment 30min 1h 2h 4h 8h 12h 24h
Ptges
KLA  Compactin  Compactin+KLA
 prostaglandin E synthase (Ptges), mRNA [NM_022415] KLA 1.02 2.22 4.45 10.45 19.28 19.39 18.36
 Compactin .98 1.14 .99 1.13 1.05 1.23 1.01
 Compactin+KLA .90 2.11 4.78 11.00 17.86 18.56 16.72

RAW 264.7 cells treated with Kdo2-Lipid A (KLA) and compactin

Gene Time course graph Description Treatment 30min 1h 2h 4h 8h 12h 24h
Ptges
KLA  Compactin  Compactin+KLA
 prostaglandin E synthase (Ptges), mRNA [NM_022415] KLA .89 1.64 1.98 2.68 3.48 4.51 7.67
 Compactin .84 .91 .92 .92 1.04 1.11 1.29
 Compactin+KLA .91 1.46 1.94 2.37 3.09 5.56 7.88