Microarray data for Sgms1: fold-change ratios

Bone marrow-derived macrophage cells treated with Kdo2-Lipid A (KLA) and ATP

Gene Time course graph Description Treatment 15min 30min 1h 2h 4h 8h 20h
Sgms1
KLA  ATP  ATP+KLA
sphingomyelin synthase 1 (Sgms1), mRNA [NM_144792] KLA .84 .84 .58 .94 1.49 .66 .71
 ATP .98 .97 1.57 1.85 1.32 1.60 .57
 ATP+KLA .82 .73 .90 .97 .67 .81 .55

Bone marrow-derived macrophage cells treated with 25-hydroxy-cholesterol +/- lipid-depleted media containing compactin

Gene Time course graph Description Treatment 30min 1h 2h 4h 8h 12h 24h
Sgms1
25OHC/Ctl - treatment with 25-OHC / no treatment
25-OHC*/* - lipid depleted media containing compactin and treatment with 25-OHC / lipid depleted media containing compactin only
sphingomyelin synthase 1 (Sgms1), mRNA [NM_144792] 25OHC/Ctl (?) .99 1.08 .86 1.14 1.26 1.20 1.53
 25-OHC*/* (?) 1.05 1.05 .94 1.16 1.02 .85 1.09
 
 

Thioglycolate-elicited macrophage cells treated with Kdo2-Lipid A (KLA) and compactin

Gene Time course graph Description Treatment 30min 1h 2h 4h 8h 12h 24h
Sgms1
KLA  Compactin  Compactin+KLA
sphingomyelin synthase 1 KLA 1.18 3.44 2.59 .56 .84 .52 .49
 Compactin 1.07 .90 1.09 .98 .99 1.09 1.04
 Compactin+KLA 1.01 3.10 2.76 .63 .79 .54 .62
Sgms1
KLA  Compactin  Compactin+KLA
sphingomyelin synthase 1 (Sgms1), mRNA [NM_144792] KLA .99 3.76 2.68 .56 .83 .59 .55
 Compactin .88 1.40 1.10 1.23 1.12 1.17 1.05
 Compactin+KLA .97 3.88 2.54 .67 .76 .56 .65

RAW 264.7 cells treated with Kdo2-Lipid A (KLA) and compactin

Gene Time course graph Description Treatment 30min 1h 2h 4h 8h 12h 24h
Sgms1
KLA  Compactin  Compactin+KLA
sphingomyelin synthase 1 KLA 1.06 1.37 1.10 1.01 1.38 1.21 .88
 Compactin .91 .87 1.06 .87 1.26 1.98 2.23
 Compactin+KLA .98 1.13 1.63 1.11 1.33 1.51 .90
Sgms1
KLA  Compactin  Compactin+KLA
sphingomyelin synthase 1 (Sgms1), mRNA [NM_144792] KLA .90 1.29 1.06 .73 1.26 1.04 1.01
 Compactin 1.04 .88 .86 .77 1.29 1.95 2.06
 Compactin+KLA .79 1.23 1.31 .88 1.20 1.50 1.07