Microarray data for Sgms2: fold-change ratios

Bone marrow-derived macrophage cells treated with Kdo2-Lipid A (KLA) and ATP

Gene Time course graph Description Treatment 15min 30min 1h 2h 4h 8h 20h
Sgms2
KLA  ATP  ATP+KLA
 sphingomyelin synthase 2 (Sgms2), mRNA [NM_028943] KLA 1.21 1.19 1.18 1.03 .89 .92 1.42
 ATP 1.00 .99 1.08 1.22 3.11 11.82 3.08
 ATP+KLA 1.17 1.16 1.07 1.21 1.17 3.37 5.49

Bone marrow-derived macrophage cells treated with 25-hydroxy-cholesterol +/- lipid-depleted media containing compactin

Gene Time course graph Description Treatment 30min 1h 2h 4h 8h 12h 24h
Sgms2
25OHC/Ctl - treatment with 25-OHC / no treatment
25-OHC*/* - lipid depleted media containing compactin and treatment with 25-OHC / lipid depleted media containing compactin only
sphingomyelin synthase 2 (Sgms2), mRNA [NM_028943] 25OHC/Ctl (?) .96 .98 1.01 1.07 1.06 1.08 1.15
 25-OHC*/* (?) 1.00 1.00 1.12 1.05 1.22 1.24 1.31
 
 

Thioglycolate-elicited macrophage cells treated with Kdo2-Lipid A (KLA) and compactin

Gene Time course graph Description Treatment 30min 1h 2h 4h 8h 12h 24h
Sgms2
KLA  Compactin  Compactin+KLA
 sphingomyelin synthase 2 (Sgms2), mRNA [NM_028943] KLA 1.08 1.46 4.16 1.88 1.44 1.52 1.91
 Compactin 1.03 .98 1.05 .95 1.02 1.06 1.14
 Compactin+KLA 1.08 1.47 4.14 1.69 1.51 1.27 1.91

RAW 264.7 cells treated with Kdo2-Lipid A (KLA) and compactin

Gene Time course graph Description Treatment 30min 1h 2h 4h 8h 12h 24h
Sgms2
KLA  Compactin  Compactin+KLA
 sphingomyelin synthase 2 (Sgms2), mRNA [NM_028943] KLA .98 1.27 1.28 1.33 1.03 1.13 1.03
 Compactin .89 1.05 .97 .97 .97 .91 1.11
 Compactin+KLA 1.06 .97 1.16 1.24 1.03 .97 1.05