Microarray data for Sqle: fold-change ratios

Bone marrow-derived macrophage cells treated with Kdo2-Lipid A (KLA) and ATP

Gene Time course graph Description Treatment 15min 30min 1h 2h 4h 8h 20h
Sqle
KLA  ATP  ATP+KLA
 squalene epoxidase (Sqle), mRNA [NM_009270] KLA .41 .38 .35 .27 .26 .24 .42
 ATP 1.00 1.02 1.10 .92 .83 .65 1.37
 ATP+KLA .43 .42 .32 .31 .26 .23 .31

Bone marrow-derived macrophage cells treated with 25-hydroxy-cholesterol +/- lipid-depleted media containing compactin

Gene Time course graph Description Treatment 30min 1h 2h 4h 8h 12h 24h
Sqle
25OHC/Ctl - treatment with 25-OHC / no treatment
25-OHC*/* - lipid depleted media containing compactin and treatment with 25-OHC / lipid depleted media containing compactin only
squalene epoxidase (Sqle), mRNA [NM_009270] 25OHC/Ctl (?) .99 .84 .74 .30 .32 .29 .27
 25-OHC*/* (?) 1.09 .87 .65 .22 .17 .16 .14
 
 

Thioglycolate-elicited macrophage cells treated with Kdo2-Lipid A (KLA) and compactin

Gene Time course graph Description Treatment 30min 1h 2h 4h 8h 12h 24h
Sqle
KLA  Compactin  Compactin+KLA
 squalene epoxidase (Sqle), mRNA [NM_009270] KLA .97 .97 .82 .57 .64 .50 .55
 Compactin 1.03 .95 1.00 1.14 1.15 1.17 1.07
 Compactin+KLA .98 .94 .87 .68 .96 .63 .66

RAW 264.7 cells treated with Kdo2-Lipid A (KLA) and compactin

Gene Time course graph Description Treatment 30min 1h 2h 4h 8h 12h 24h
Sqle
KLA  Compactin  Compactin+KLA
 squalene epoxidase (Sqle), mRNA [NM_009270] KLA .96 1.04 1.06 .53 .74 .79 .98
 Compactin 1.04 .93 .97 1.22 1.06 1.14 1.09
 Compactin+KLA 1.07 1.04 .96 .65 .89 .96 1.00