Lipidomics studies on macrophages - bone marrow-derived macrophages treated with 25-hydroxy-cholesterol +/- lipid-depleted media containing compactin

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Details: 7alpha-hydroxy-cholesterol

Legend:graph_icon: View detailed data for replicatesgraph_icon: View time course graphs
Ctrl:Untreated BMDM cells (control)
25-OHC: Cells treated with 25-OH-cholesterol at time 0
*: BMDM cells in lipid-depleted media containing compactin
25-OHC*: cells in lipid-depleted media containing compactin and treated with 25-OHC at time 0
4.622.49 2.1 2.55 1.58 1.85 1.49 1.19 5.77 2.44 2.66 2.43 2.16 1.63 1.47 0.903 3.09 3.16 2.95 2.84 2.65 2.55 2.13 1.01 1.71 2.21 2.16 1.67 1.77 1.68 3.17 2.17 0.527 0.913 0.773 0.953 0.6 0.503 0.497 1.5 0.583 0.783 0.68 0.653 0.73 0.59 0.727 0.383 0.5 0.95 1.12 0.55 0.76 0.58 0.52 0.82 0.6 0.49 0.59 0.53 0.48 0.42 0.47 0.35 0.74 0.56 0.5 0.6 0.87 0.4 0.51 0.58 0.803 0.886 0.93 0.632 0.57 0.622 1.04 0.582 1.39 1.36 1.05 0.513 0.857 0.948 1.04 0.641 0.725 0.921 0.829 0.764 1.22 0.932 0.85 0.884 2.5 4.52 1.74 2.99 1.6 1.68 4.51 2.1 2.06 3.38 1.65 1.78 1.97 2.16 5.34 2.5 2.64 3.06 1.26 1.78 1.98 1.72 4.11 1.3 3.15 2.52 1.58 1.46 1.69 1.41 4.06 1.63 4.48 3.33 1.9 1.3 1.41 1.37 1.86 2.12 3.87 3.35 1.66 1.43 1.5 1.58 1.92 1.91 1.45 1.36 1.19 2.03 3.06 2.37 0.76 0.54 0.34 0.032 0.031 0.027 0.56 0.353 0.361 0.315 0.395 0.689 0.459 0.437 0.455 0.485 0.333 0.634 0.304 0.41 0.298 0.344 0.587 0.533 0.431 0.433 0.4 0.314 0.374 0.486 2.05 1.51 1.73 1.46 1.21 0.654 0.583 0.362 1.12 0.963 0.929 10.3 10.8 50.3 7.27 6.61 9.68 30.5 28.8 30.1 31.5 58.8 64.5 54.7 52.6 6.82 8.87 6.68 8.79 8.39 12 5.54 3.92 4.51 6.77 6.88 4.6 3.57 4.66 5.57 4.81 3.18 3.64 10.4 7.54 6.11 4.2 3.63 3.53 5.74 4.68 2.36 10.8 9.14 5 1.09 1.08 1.74 2.01 1.25 1.79 3.1 1.44 1.22 1.32 0.994 1.81 2.68 5.45 6.83 2.19 3.11 1.58 113 42.2 196 106 90 45.7 243 148 57.3 53 131 67.4 158 66.4 56.4 106 126 41.3
Details Graph
Individual
Expts		Ave Biol. Reps
LM_ID Name 25-OHC*
*
25-OHC
Ctrl
 0 hrs		 25-OHC*
*
25-OHC
Ctrl
 30 min		 25-OHC*
*
25-OHC
Ctrl
 1 hr		 25-OHC*
*
25-OHC
Ctrl
 2 hrs		 25-OHC*
*
25-OHC
Ctrl
 4 hrs		 25-OHC*
*
25-OHC
Ctrl
 8 hrs		 25-OHC*
*
25-OHC
Ctrl
 12 hrs		 25-OHC*
*
25-OHC
Ctrl
 24 hrs		Units
. . . .
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
 
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
(MSJ070605)		LMST01010013 7alpha-hydroxy-cholesterol pmol/ug DNA
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
 
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
(MSJ070612)		LMST01010013 7alpha-hydroxy-cholesterol pmol/ug DNA
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
 
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
(MSJ070820)		LMST01010013 7alpha-hydroxy-cholesterol pmol/ug DNA
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
 
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
(MSJ071011)		LMST01010013 7alpha-hydroxy-cholesterol pmol/1E6 cells
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
 
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
(MSJ070726)		LMST01010013 7alpha-hydroxy-cholesterol pmol/ug DNA
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
 
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
(MSJ070808)		LMST01010013 7alpha-hydroxy-cholesterol pmol/ug DNA
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
 
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
(MSJ070823)		LMST01010013 7alpha-hydroxy-cholesterol pmol/ug DNA
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
 
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
(BCJ080212)		LMST01010013 7alpha-hydroxy-cholesterol pmol/ug DNA
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
 
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
(BCJ080219)		LMST01010013 7alpha-hydroxy-cholesterol pmol/ug DNA
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
 
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
(BCJ080226)		LMST01010013 7alpha-hydroxy-cholesterol pmol/ug DNA
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
 
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
(BCD080211)		LMST01010013 7alpha-hydroxy-cholesterol pmol/ug DNA
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
 
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
(BCD080311)		LMST01010013 7alpha-hydroxy-cholesterol pmol/ug DNA
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
 
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
(BCD080408)		LMST01010013 7alpha-hydroxy-cholesterol pmol/ug DNA
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
 
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
(BCD090512)		LMST01010013 7alpha-hydroxy-cholesterol pmol/ug DNA
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
 
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
(BCD090512)		LMST01010013 7alpha-hydroxy-cholesterol pmol/ug DNA
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
 
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
(BCD090716)		LMST01010013 7alpha-hydroxy-cholesterol pmol/ug DNA
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
 
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
(BCD090716)		LMST01010013 7alpha-hydroxy-cholesterol pmol/ug DNA
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
 
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
(BCD090805)		LMST01010013 7alpha-hydroxy-cholesterol pmol/ug DNA
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
 
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
(BCD090805)		LMST01010013 7alpha-hydroxy-cholesterol pmol/ug DNA
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
 
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
(BCD100322)		LMST01010013 7alpha-hydroxy-cholesterol -
0.94
-
0.65		 0.7
1.98
0.76
1.49		 0.29
2.9
0.99
1		 3.61
0.8
0.8
0.33		 3.85
2.37
2.02
0.68		 1.4
1
0.64
0.32		 2.1
1.18
0.68
0.81		 2.17
2.74
3.11
3.94		 pmol/ug DNA
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
 
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
(BCD100322)		LMST01010013 7alpha-hydroxy-cholesterol -
1.03
-
1.31		 1.07
0.96
1.55
1.07		 1.03
0.49
1.41
1.29		 1.11
0.75
1.19
1.45		 1.45
1.19
1.94
1.49		 0.98
0.77
1.68
1.2		 0.9
0.68
1.5
0.73		 0.94
0.74
1.77
1.2		 pmol/ug DNA
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
 
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
(BCD100322)		LMST01010013 7alpha-hydroxy-cholesterol -
1.37
-
2.57		 1.64
1.87
3.17
2.36		 1.48
1.44
3.22
2.66		 1.47
1.54
2.86
2.19		 1.57
1.31
4.38
2.93		 1.92
1.81
2.96
3.11		 2.47
2.21
6.98
2.76		 2.39
2.48
6.77
4.62		 pmol/ug DNA
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
 
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
(BCD100322)		LMST01010013 7alpha-hydroxy-cholesterol -
9.2
-
6.65		 7.91
20.6
8.54
9.94		 3.56
34.3
10.6
11.1		 28.6
7.11
11.5
4.04		 27.6
19.5
15.7
6.16		 15.2
11.2
8.7
4.84		 20.8
9.79
9.36
12.2		 25.6
23.4
31.6
44.2		 pmol/sample
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
 
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
(BCD100322)		LMST01010013 7alpha-hydroxy-cholesterol -
10.1
-
13.4		 12.1
9.98
17.4
7.14		 12.6
5.8
15
14.4		 8.78
6.66
17.1
17.8		 10.4
9.8
15
13.5		 10.7
8.59
22.8
18.2		 8.89
5.64
20.6
11		 11.1
6.33
18
13.5		 pmol/sample
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
 
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
(BCD100322)		LMST01010013 7alpha-hydroxy-cholesterol -
13.4
-
26.3		 18.5
19.4
35.6
15.7		 18.2
17
34.3
29.6		 11.6
13.7
41.1
26.8		 11.3
10.8
34
26.5		 20.9
20.2
40.3
47.1		 24.4
18.3
96
41.4		 28.2
21.2
68.8
51.9		 pmol/sample
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
 
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
(BCJ070515)		LMST01010013 7alpha-hydroxy-cholesterol pmol/ug DNA
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
 
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
(BCJ070619)		LMST01010013 7alpha-hydroxy-cholesterol pmol/ug DNA
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
 
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
(BCJ070724)		LMST01010013 7alpha-hydroxy-cholesterol pmol/ug DNA
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
 
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
(BCJ050725)		LMST01010013 7alpha-hydroxy-cholesterol ug/extract
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
 
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
(BCJ060926)		LMST01010013 7alpha-hydroxy-cholesterol pmol/ug DNA
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
 
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
(BCJ061017)		LMST01010013 7alpha-hydroxy-cholesterol pmol/ug DNA
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
 
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
(BCJ061024)		LMST01010013 7alpha-hydroxy-cholesterol pmol/ug DNA
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
 
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
(BCJ061024)		LMST01010013 7alpha-hydroxy-cholesterol pmol/ug DNA
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
 
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
(BCJ061010)		LMST01010013 7alpha-hydroxy-cholesterol pmol/ug DNA
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
 
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
(MSJ070716)		LMST01010013 7alpha-hydroxy-cholesterol pmol/1E6 cells
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
 
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
(MSJ070927)		LMST01010013 7alpha-hydroxy-cholesterol pmol/1E6 cells
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
 
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
(MSJ070927)		LMST01010013 7alpha-hydroxy-cholesterol pmol/1E6 cells
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
 
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
(MSJ070927)		LMST01010013 7alpha-hydroxy-cholesterol pmol/1E6 cells
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
 
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
(BCJSUB003)		LMST01010013 7alpha-hydroxy-cholesterol pmol/mg protein
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
 
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
(BCISUB300)		LMST01010013 7alpha-hydroxy-cholesterol pmol/mg protein
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
 
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
(MSJ110501)		LMST01010013 7alpha-hydroxy-cholesterol pmol/1E6 cells
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
 
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
(BCD110605)		LMST01010013 7alpha-hydroxy-cholesterol umol/sample
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
 
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
(BCD110605)		LMST01010013 7alpha-hydroxy-cholesterol umol/ml of media
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
 
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
(BCG120120)		LMST01010013 7alpha-hydroxy-cholesterol pmol/10E6 cells
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
 
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
(BCG120131)		LMST01010013 7alpha-hydroxy-cholesterol pmol/10E6 cells
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
 
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
(BCG120212)		LMST01010013 7alpha-hydroxy-cholesterol pmol/10E6 cells
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
 
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
(BCG120308)		LMST01010013 7alpha-hydroxy-cholesterol pmol/10E6 cells
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
 
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
(NASH0013)		LMST01010013 7alpha-hydroxy-cholesterol pmol/mg
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
 
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
(NASH0008)		LMST01010013 7alpha-hydroxy-cholesterol pmol/ml