Lipidomics studies on macrophages - bone marrow-derived macrophages treated with 25-hydroxy-cholesterol +/- lipid-depleted media containing compactin

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Details: C18:1 Sphingomyelin Legend: : View detailed data for replicates: View time course graphs Ctrl: Untreated BMDM cells (control) 25-OHC: Cells treated with 25-OH-cholesterol at time 0 *: BMDM cells in lipid-depleted media containing compactin 25-OHC*: cells in lipid-depleted media containing compactin and treated with 25-OHC at time 0 0.770.91 1.25 0.96 0.94 0.71 0.7 0.76 1.07 1.04 1.04 1.19 1.01 0.86 0.72 0.82 0.79 0.73 0.81 0.95 0.81 0.59 0.46 0.65 0.69 0.49 0.49 0.57 0.59 0.58 0.58 0.69 0.53 0.58 0.39 0.51 0.45 0.48 0.4 0.59 0.67 0.52 0.63 0.7 0.54 0.48 0.67 0.47 2.38 2.17 1.47 2.46 1.23 1.21 1.46 1.85 14.9 12.4 10.6 11.1 11.5 11.8 13.2 16.8 0.398 0.286 0.379 0.274 0.467 0.523 0.557 0.698 1.19 1.09 0.733 1.23 0.614 0.606 0.732 0.927 0.981 0.812 0.696 0.733 0.753 0.778 0.868 1.1 0.408 0.484 0.322 0.596 0.452 0.526 0.373 0.316 0.487 0.399 0.403 0.489 0.386 0.433 0.369 0.395 0.44 0.432 0.44 0.377 0.332 0.284 0.334 0.329 0.38 0.435 0.387 0.413 0.353 0.327 0.345 0.297 16.9 5.3 9.82 7.89 7.18 20.1 16.9 13.1 14.5 5.23 6967 2015 3827 4278 1856 4899 3846 5506 5839 1863 21.9 6.82 8.8 50.6 8.46 6.18 38.9 5.14 6.16 11.2 Details Graph Individual Expts Ave Biol. Reps LM_ID Name 25-OHC* * 25-OHC Ctrl 0 hrs 25-OHC* * 25-OHC Ctrl 30 min 25-OHC* * 25-OHC Ctrl 1 hr 25-OHC* * 25-OHC Ctrl 2 hrs 25-OHC* * 25-OHC Ctrl 4 hrs 25-OHC* * 25-OHC Ctrl 8 hrs 25-OHC* * 25-OHC Ctrl 12 hrs 25-OHC* * 25-OHC Ctrl 24 hrs Units . . . . Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp   Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp (BCJ080212) LMSP03010029 C18:1 Sphingomyelin pmol/ug DNA Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp   Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp (BCJ080219) LMSP03010029 C18:1 Sphingomyelin pmol/ug DNA Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp   Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp (BCJ080226) LMSP03010029 C18:1 Sphingomyelin pmol/ug DNA Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp   Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp (BCD090127) LMSP03010029 C18:1 Sphingomyelin pmol/ug DNA Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp   Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp (BCD090114) LMSP03010029 C18:1 Sphingomyelin pmol/ug DNA Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp   Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp (BCD090401) LMSP03010029 C18:1 Sphingomyelin pmol/ug DNA Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp   Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp (BCD090512) LMSP03010029 C18:1 Sphingomyelin pmol/ug DNA Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp   Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp (BCD090512) LMSP03010029 C18:1 Sphingomyelin pmol/sample Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp   Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp (BCJ081209) LMSP03010029 C18:1 Sphingomyelin pmol/ug DNA Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp   Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp (BCD090512) LMSP03010029 C18:1 Sphingomyelin pmol/ug DNA Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp   Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp (BCD090512) LMSP03010029 C18:1 Sphingomyelin pmol/ug DNA Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp   Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp (BCD090716) LMSP03010029 C18:1 Sphingomyelin pmol/ug DNA Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp   Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp (BCD090716) LMSP03010029 C18:1 Sphingomyelin pmol/ug DNA Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp   Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp (BCD090805) LMSP03010029 C18:1 Sphingomyelin pmol/ug DNA Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp   Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp (BCD090805) LMSP03010029 C18:1 Sphingomyelin pmol/ug DNA Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp   Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp (BCD100322) LMSP03010029 C18:1 Sphingomyelin - 0.56 - 0.76 0.62 0.64 0.65 1.13 0.5 0.45 0.69 0.69 0.71 0.66 0.51 0.67 0.8 0.72 0.96 0.79 0.54 0.5 0.59 0.52 0.58 0.61 0.33 0.57 0.41 0.62 0.66 0.65 pmol/ug DNA Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp   Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp (BCD100427) LMSP03010029 C18:1 Sphingomyelin - 0.76 - 0.8 0.62 0.65 0.63 0.53 0.66 0.71 0.64 0.51 0.85 0.62 0.54 0.63 0.8 0.89 0.73 0.9 0.51 0.51 0.62 0.6 0.62 0.63 0.61 0.63 0.34 0.61 0.54 0.66 pmol/ug DNA Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp   Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp (BCD100624) LMSP03010029 C18:1 Sphingomyelin - 0.63 - 0.99 0.59 0.93 1.24 0.98 0.67 0.73 1.15 1.02 0.64 0.65 1.11 0.93 0.64 0.62 1.61 1.45 0.55 0.6 0.9 1.23 0.62 0.71 1.15 0.94 0.4 0.62 1.08 1.29 pmol/ug DNA Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp   Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp (BCD100322) LMSP03010029 C18:1 Sphingomyelin - 5.48 - 7.77 7 6.65 7.3 7.54 6.13 5.32 7.35 7.69 5.62 5.86 7.33 8.2 5.74 5.93 7.44 7.15 5.88 5.58 8.02 7.87 5.73 5.06 4.54 8.55 4.83 5.3 6.7 7.3 pmol/sample Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp   Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp (BCD100427) LMSP03010029 C18:1 Sphingomyelin - 5.64 - 7.52 5.12 5.75 5.59 5.78 6.11 7.07 6.36 5.92 6.53 6.93 6.6 6.82 6.2 5.88 6.83 6.38 5.12 5.45 7.4 6.23 5.23 6.09 6.54 8.73 3.39 5.65 5.79 6.63 pmol/sample Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp   Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp (BCD100624) LMSP03010029 C18:1 Sphingomyelin - 5.05 - 7.39 4.29 5.37 7.34 6.97 4.92 4.54 7.48 7.45 4.46 4.3 6.32 7.26 4.38 4.22 7.22 6.84 3.71 4.01 6.8 6.88 3.2 3.25 6.19 6.66 2.14 3.02 5 6.67 pmol/sample Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp   Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp (NASH0003) LMSP03010029 C18:1 Sphingomyelin pmol/mg Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp   Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp (NASH0002) LMSP03010029 C18:1 Sphingomyelin pmol/ml Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp   Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp (NASH0009) LMSP03010029 C18:1 Sphingomyelin pmol/ml