Lipidomics studies on macrophages - bone marrow-derived macrophages treated with 25-hydroxy-cholesterol +/- lipid-depleted media containing compactin

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Details: C20DH Sphingomyelin Legend: : View detailed data for replicates: View time course graphs Ctrl: Untreated BMDM cells (control) 25-OHC: Cells treated with 25-OH-cholesterol at time 0 *: BMDM cells in lipid-depleted media containing compactin 25-OHC*: cells in lipid-depleted media containing compactin and treated with 25-OHC at time 0 4.492.572.164.884.584.755.045.374.564.738.717.237.976.416.526.245.651.971.712.731.181.591.320.9590.4930.237 0.217 3.31 2.16 1.99 3.65 2.25 2 1.76 1.01 0.527 29.5 0.72 0.62 1.14 0.44 0.42 0.72 0.63 0.43 0.89 1.14 1.14 1.04 0.65 0.66 0.62 0.53 0.8 0.63 0.72 0.75 0.78 0.53 0.35 0.31 - - - - - - - - 3.3 4.17 2.64 4.17 1.99 2.01 2.5 3.08 20.7 23.7 19.1 18.9 18.5 19.7 22.6 27.9 1.78 1.4 1.36 1.34 1.44 1.18 1.61 1.67 1.65 2.08 1.32 2.08 0.993 1.01 1.25 1.54 1.36 1.56 1.25 1.24 1.22 1.29 1.48 1.83 0.377 0.533 0.487 0.63 0.484 0.526 0.612 0.345 0.45 0.439 0.61 0.517 0.413 0.433 0.604 0.431 1.07 1 1.4 1.14 1.14 1.04 1.51 1.09 0.924 1.01 1.23 1.25 1.21 1.19 1.56 0.979 26.9 28.8 26.8 30.3 8.62 27.4 26.6 26.2 25.8 23.9 26.6 24.8 19.9 29 30.1 26.8 22 20.2 23.2 30.7 31 28.9 27.1 26.7 30.2 18.5 13.7 16.3 25.8 21.2 15.8 11.7 23.3 28.4 20.4 7.42 16.7 15.8 19.5 9.28 15 17.2 12.5 16 18.4 1543 806 1684 1166 1053 1124 1855 1814 820 1303 26.3 Details Graph Individual Expts Ave Biol. Reps LM_ID Name 25-OHC* * 25-OHC Ctrl 0 hrs 25-OHC* * 25-OHC Ctrl 30 min 25-OHC* * 25-OHC Ctrl 1 hr 25-OHC* * 25-OHC Ctrl 2 hrs 25-OHC* * 25-OHC Ctrl 4 hrs 25-OHC* * 25-OHC Ctrl 8 hrs 25-OHC* * 25-OHC Ctrl 12 hrs 25-OHC* * 25-OHC Ctrl 24 hrs Units . . . . Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp   Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp (BCI060111) LMSP03010021 C20DH Sphingomyelin pmol/ug DNA Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp   Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp (BCI060122) LMSP03010021 C20DH Sphingomyelin pmol/ug DNA Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp   Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp (BCI060126) LMSP03010021 C20DH Sphingomyelin pmol/ug DNA Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp   Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp (BCI060614) LMSP03010021 C20DH Sphingomyelin pmol/ug DNA Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp   Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp (BCJ060718) LMSP03010021 C20DH Sphingomyelin pmol/ug DNA Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp   Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp (BCJ070123) LMSP03010021 C20DH Sphingomyelin pmol/1E6 cells Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp   Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp (BCG070312) LMSP03010021 C20DH Sphingomyelin pmol/1E6 cells Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp   Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp (BCG061213) LMSP03010021 C20DH Sphingomyelin pmol/1E6 cells Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp   Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp (BCJ070619) LMSP03010021 C20DH Sphingomyelin pmol/ug DNA Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp   Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp (BCJ070515) LMSP03010021 C20DH Sphingomyelin pmol/ug DNA Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp   Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp (BCJ070515) LMSP03010021 C20DH Sphingomyelin pmol/ug DNA Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp   Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp (BCD070815) LMSP03010021 C20DH Sphingomyelin pmol/1E6 cells Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp   Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp (BCISUB000) LMSP03010021 C20DH Sphingomyelin pmol/mg protein Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp   Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp (BCJ080212) LMSP03010021 C20DH Sphingomyelin pmol/ug DNA Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp   Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp (BCJ080219) LMSP03010021 C20DH Sphingomyelin pmol/ug DNA Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp   Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp (BCJ080226) LMSP03010021 C20DH Sphingomyelin pmol/ug DNA Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp   Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp (BCD090401) LMSP03010021 C20DH Sphingomyelin pmol/ug DNA Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp   Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp (BCD090512) LMSP03010021 C20DH Sphingomyelin pmol/ug DNA Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp   Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp (BCD090512) LMSP03010021 C20DH Sphingomyelin pmol/sample Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp   Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp (BCJ081209) LMSP03010021 C20DH Sphingomyelin pmol/ug DNA Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp   Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp (BCD090512) LMSP03010021 C20DH Sphingomyelin pmol/ug DNA Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp   Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp (BCD090512) LMSP03010021 C20DH Sphingomyelin pmol/ug DNA Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp   Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp (BCD090716) LMSP03010021 C20DH Sphingomyelin pmol/ug DNA Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp   Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp (BCD090716) LMSP03010021 C20DH Sphingomyelin pmol/ug DNA Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp   Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp (BCD090805) LMSP03010021 C20DH Sphingomyelin pmol/ug DNA Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp   Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp (BCD090805) LMSP03010021 C20DH Sphingomyelin pmol/ug DNA Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp   Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp (BCD100322) LMSP03010021 C20DH Sphingomyelin - 5.12 - 5.75 5.1 5.85 4.51 6.52 3.78 2.78 4.53 4.29 6.56 5.39 3.1 4.03 7.96 6.97 7.36 5.86 5.02 4.9 4.34 3.77 6.35 6.42 3.62 4.14 4.54 5.96 5.11 4.55 pmol/ug DNA Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp   Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp (BCD100427) LMSP03010021 C20DH Sphingomyelin - 4.54 - 3.91 7.09 5.1 4.77 2.41 7.04 6.59 4.72 4.35 8.04 5.15 3.96 5.55 8.68 10.5 5.65 6.49 7.8 6.82 4.28 - 8.59 8.01 5.95 4.3 5.12 7.66 3.92 5.08 pmol/ug DNA Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp   Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp (BCD100624) LMSP03010021 C20DH Sphingomyelin - 7.27 - 8.36 8.06 11.7 11.6 8.75 8.83 10 12.5 8.8 10.2 10.2 10.9 8.55 11.3 10 18.9 14.4 9.61 10.2 11 16.1 10.8 15.9 14.5 12.6 7.76 14.8 14.3 15.4 pmol/ug DNA Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp   Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp (BCD100322) LMSP03010021 C20DH Sphingomyelin - 50.1 - 58.8 57.6 60.8 50.7 43.5 46.4 32.9 48.3 47.8 51.9 47.9 44.5 49.3 57.1 57.4 57.1 53.1 54.6 54.7 59 57.1 62.8 53.3 49.8 62.1 53.5 51 51.9 51.1 pmol/sample Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp   Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp (BCD100427) LMSP03010021 C20DH Sphingomyelin - 33.7 - 36.8 58.6 45.1 42.3 26.3 65.2 65.6 46.9 50.5 61.8 57.5 48.4 60.1 67.3 69.5 52.8 46 78.4 72.9 51.1 - 72.4 77.4 63.8 59.6 51 71 42.1 51.1 pmol/sample Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp   Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp (BCD100624) LMSP03010021 C20DH Sphingomyelin - 58.2 - 62.4 58.6 67.3 68.8 62.2 64.8 62.5 81.4 64.3 70.8 67.5 61.8 66.8 77.4 68.3 84.9 68.2 64.9 68.4 83.3 90.1 56 72.7 78.2 89.5 41.5 72.3 66.1 79.5 pmol/sample Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp   Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp (BCD110605) LMSP03010021 C20DH Sphingomyelin pmol/sample Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp   Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp (BCD110605) LMSP03010021 C20DH Sphingomyelin pmol/10E6 cells Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp   Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp (BCG120120) LMSP03010021 C20DH Sphingomyelin pmol/10E6 cells Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp   Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp (BCG120131) LMSP03010021 C20DH Sphingomyelin pmol/10E6 cells Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp   Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp (BCG120131) LMSP03010021 C20DH Sphingomyelin pmol/10E6 cells Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp   Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp (BCG120308) LMSP03010021 C20DH Sphingomyelin pmol/10E6 cells Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp   Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp (NASH0010) LMSP03010021 C20DH Sphingomyelin pmol/mg Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp   Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp (NASH0006) LMSP03010021 C20DH Sphingomyelin pmol/ml Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp   Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp (BCJ070122) LMSP03010021 C20DH Sphingomyelin pmol/1E6 cells Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp   Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp (BCJ070124) LMSP03010021 C20DH Sphingomyelin pmol/1E6 cells Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp   Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp (BCISUB300) LMSP03010021 C20DH Sphingomyelin pmol/mg protein