Lipidomics studies on macrophages - bone marrow-derived macrophages treated with 25-hydroxy-cholesterol +/- lipid-depleted media containing compactin

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Details: Sphinganine-P Legend: : View detailed data for replicates: View time course graphs Ctrl: Untreated BMDM cells (control) 25-OHC: Cells treated with 25-OH-cholesterol at time 0 *: BMDM cells in lipid-depleted media containing compactin 25-OHC*: cells in lipid-depleted media containing compactin and treated with 25-OHC at time 0 0.0690.1180.0560.4370.213 0.097 0.79 0.617 0.677 0.275 0.11 0.147 0.015 0.01 0.01 0.47 0.42 0.47 0.29 0.32 0.3 0.26 0.15 0.21 0.13 0.18 0.14 0.12 0.06 0.08 0.05 0.11 0.09 0.08 0.07 0.06 0.06 0.03 0.02 0.009 0.009 0.011 0.012 0.006 0.008 0.01 0.008 0.007 0.008 0.01 0.01 0.015 0.013 0.008 0.008 0.007 0.006 0.013 0.011 0.01 0.08 0.05 0.02 0.04 0.08 0.02 0.02 0.03 - - - - 0.03 0.07 0.06 0.04 0.01 - - 0.01 - - 0.01 - - - - - - - - - - - - - - - - - 0.018 0.009 0.025 0.013 0.026 0.047 0.016 0.022 0.012 0.016 0.005 0.028 0.022 0.009 0.008 0.025 0.01 0.012 0.005 0.016 0.027 0.012 0.009 0.029 0.013 0.014 0.008 0.021 0.028 0.007 0.014 0.012 0.016 0.012 0.01 0.017 0.024 0.005 0.014 0.015 0.012 0.006 0.006 0.01 0.009 0.004 0.009 0.012 0.01 0.006 0.005 0.011 0.009 0.005 0.009 0.011 0.167 0.063 0.143 0.27 1.2 0.059 0.087 0.072 0.086 0.072 0.047 0.075 0.044 0.062 0.108 0.09 0.072 0.057 0.069 0.054 0.063 0.051 0.051 0.08 0.109 0.111 0.094 0.1 0.066 0.082 0.038 0.03 0.081 0.03 0.04 0.032 0.035 0.012 0.071 0.021 1.02 0.015 0.008 0.048 0.049 64.7 87.2 54.8 94.6 56.3 47.6 33.7 31.6 141 42.2 0.4 0.059 0.357 0.539 0.347 0.577 0.283 0.557 0.361 0.576 1.08 1.21 0.786 0.679 0.941 0.696 0.703 1.82 1.95 1.69 1.35 1.27 1.05 1.18 1.74 2.38 2.93 2.71 2.13 1.28 0.911 Details Graph Individual Expts Ave Biol. Reps LM_ID Name 25-OHC* * 25-OHC Ctrl 0 hrs 25-OHC* * 25-OHC Ctrl 30 min 25-OHC* * 25-OHC Ctrl 1 hr 25-OHC* * 25-OHC Ctrl 2 hrs 25-OHC* * 25-OHC Ctrl 4 hrs 25-OHC* * 25-OHC Ctrl 8 hrs 25-OHC* * 25-OHC Ctrl 12 hrs 25-OHC* * 25-OHC Ctrl 24 hrs Units . . . . Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp   Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp (BCI060111) LMSP01050002 Sphinganine-P pmol/ug DNA Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp   Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp (BCJ060718) LMSP01050002 Sphinganine-P pmol/ug DNA Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp   Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp (BCJ070123) LMSP01050002 Sphinganine-P pmol/1E6 cells Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp   Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp (BCG070312) LMSP01050002 Sphinganine-P pmol/1E6 cells Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp   Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp (BCG061213) LMSP01050002 Sphinganine-P pmol/1E6 cells Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp   Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp (BCJ070619) LMSP01050002 Sphinganine-P pmol/ug DNA Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp   Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp (BCJ070515) LMSP01050002 Sphinganine-P pmol/ug DNA Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp   Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp (BCJ070515) LMSP01050002 Sphinganine-P pmol/ug DNA Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp   Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp (BCD070815) LMSP01050002 Sphinganine-P pmol/1E6 cells Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp   Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp (BCJ080212) LMSP01050002 Sphinganine-P pmol/ug DNA Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp   Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp (BCJ080219) LMSP01050002 Sphinganine-P pmol/ug DNA Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp   Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp (BCJ080226) LMSP01050002 Sphinganine-P pmol/ug DNA Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp   Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp (BCI081123) LMSP01050002 Sphinganine-P pmol/ug DNA Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp   Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp (BCI081130) LMSP01050002 Sphinganine-P pmol/ug DNA Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp   Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp (BCI081207) LMSP01050002 Sphinganine-P pmol/ug DNA Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp   Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp (BCD090127) LMSP01050002 Sphinganine-P pmol/ug DNA Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp   Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp (BCD090114) LMSP01050002 Sphinganine-P pmol/ug DNA Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp   Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp (BCD090401) LMSP01050002 Sphinganine-P pmol/ug DNA Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp   Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp (BCD090512) LMSP01050002 Sphinganine-P pmol/ug DNA Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp   Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp (BCD090512) LMSP01050002 Sphinganine-P pmol/sample Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp   Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp (BCJ081209) LMSP01050002 Sphinganine-P pmol/ug DNA Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp   Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp (BCD090512) LMSP01050002 Sphinganine-P pmol/ug DNA Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp   Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp (BCD090512) LMSP01050002 Sphinganine-P pmol/ug DNA Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp   Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp (BCD090716) LMSP01050002 Sphinganine-P pmol/ug DNA Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp   Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp (BCD090716) LMSP01050002 Sphinganine-P pmol/ug DNA Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp   Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp (BCD090805) LMSP01050002 Sphinganine-P pmol/ug DNA Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp   Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp (BCD090805) LMSP01050002 Sphinganine-P pmol/ug DNA Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp   Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp (BCD100322) LMSP01050002 Sphinganine-P - 0.01 - 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 - 0.01 0.01 0.01 0.01 - 0.01 - 0.01 0.01 0.01 pmol/ug DNA Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp   Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp (BCD100427) LMSP01050002 Sphinganine-P - - - 0.01 - - 0.01 - 0.01 0.01 - - 0.01 - 0.01 - 0.01 - - - - 0.01 - 0.01 - - - - - 0.01 0.01 0.01 pmol/ug DNA Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp   Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp (BCD100624) LMSP01050002 Sphinganine-P - 0.01 - 0.02 0.02 0.03 0.03 0.02 0.02 0.02 0.04 0.04 0.02 0.02 0.02 0.02 0.01 0.02 0.03 0.03 - 0.02 0.01 0.02 0.03 0.03 0.01 0.01 0.02 0.03 0.01 0.02 pmol/ug DNA Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp   Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp (BCD100322) LMSP01050002 Sphinganine-P - 0.1 - 0.1 0.11 0.1 0.11 0.07 0.12 0.12 0.11 0.11 0.08 0.09 0.14 0.12 0.07 0.08 0.08 0.09 0.11 - 0.14 0.15 0.1 0.08 - 0.15 - 0.09 0.1 0.11 pmol/sample Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp   Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp (BCD100427) LMSP01050002 Sphinganine-P - - - 0.09 - - 0.09 - 0.09 0.1 - - 0.08 - 0.12 - 0.08 - - - - 0.11 - 0.1 - - - - - 0.09 0.11 0.1 pmol/sample Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp   Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp (BCD100624) LMSP01050002 Sphinganine-P - 0.08 - 0.15 0.15 0.17 0.18 0.14 0.15 0.12 0.26 0.29 0.14 0.13 0.11 0.16 0.07 0.14 0.13 0.14 - 0.13 0.08 0.11 0.15 0.14 0.05 0.07 0.11 0.15 0.05 0.1 pmol/sample Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp   Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp (BCD110605) LMSP01050002 Sphinganine-P pmol/sample Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp   Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp (BCD110605) LMSP01020001 Sphinganine-P pmol/10E6 cells Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp   Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp (BCG120120) LMSP01050002 Sphinganine-P pmol/10E6 cells Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp   Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp (BCG120131) LMSP01050002 Sphinganine-P pmol/10E6 cells Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp   Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp (BCG120131) LMSP01050002 Sphinganine-P pmol/10E6 cells Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp   Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp (BCG120308) LMSP01050002 Sphinganine-P pmol/10E6 cells Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp   Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp (NASH0009) LMSP01050002 Sphinganine-P pmol/mg Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp   Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp (NASH0008) LMSP01050002 Sphinganine-P pmol/ml Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp   Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp (NASH0006) LMSP01050002 Sphinganine-P pmol/ml Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp   Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp (BCI060122) LMSP01050002 Sphinganine-P pmol/ug DNA Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp   Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp (BCI060126) LMSP01050002 Sphinganine-P pmol/ug DNA Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp   Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp (BCI060614) LMSP01050002 Sphinganine-P pmol/ug DNA Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp   Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp (BCD070716) LMSP01050002 Sphinganine-P pmol/1E6 cells Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp   Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp (BCJ070122) LMSP01050002 Sphinganine-P pmol/1E6 cells Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp   Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp (BCJ070124) LMSP01050002 Sphinganine-P pmol/1E6 cells