Gene/Proteome Database (LMPD)
LMPD ID
LMP000004
Gene ID
Species
Mus musculus (Mouse)
Gene Name
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1
Gene Symbol
Synonyms
Siat7a
Alternate Names
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; SIAT7-A; ST6GalNAcI; ST6GalNAc I; sialyltransferase 7A; sialyltransferase 7 ((alpha-N-acetylneuraminyl 2,3-beta-galactosyl-1,3)-N-acetyl galactosaminde alpha-2,6-sialyltransferase) A
Chromosome
11
Map Location
11 E2|11
EC Number
2.4.99.3
Proteins
| alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 | |
|---|---|
| Refseq ID | NP_035501 |
| Protein GI | 126116572 |
| UniProt ID | Q9QZ39 |
| mRNA ID | NM_011371 |
| Length | 526 |
| RefSeq Status | VALIDATED |
| MTRYCRGLSQRQAFLLLTVLALLFILLFVVKDPRAKDSRCQFIWKNDASAQENQQKAEPQVPIMTLSPRVHNKETTSVSSKDLKKQEREAVQGEQAEGKEKRKLETIRPAPENPQSKAEPAAKTPVSEHLDKLPRAPGALSTRKTPMATGAVPAKKKVVQATKSPASSPHPTTRRRQRLKASEFKSEPRWDFEEEYSLDMSSLQTNCSASVKIKASKSPWLQNIFLPNITLFLDSGRFTQSEWNRLEHFAPPFGFMELNQSLVQKVVTRFPPVRQQQLLLASLPTGYSKCITCAVVGNGGILNDSRVGREIDSHDYVFRLSGAVIKGYEQDVGTRTSFYGFTAFSLTQSILILGRRGFQHVPLGKDVRYLHFLEGTRDYEWLEAMFLNQTLAKTHLSWFRHRPQEAFRNALDLDRYLLLHPDFLRYMKNRFLRSKTLDTAHWRIYRPTTGALLLLTALHLCDKVSAYGFITEGHQRFSDHYYDTSWKRLIFYINHDFRLERMVWKRLHDEGIIWLYQRPQSDKAKN | |
Gene Information
Entrez Gene ID
Gene Name
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1
Gene Symbol
Species
Mus musculus
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005794 | IEA:UniProtKB-KW | C | Golgi apparatus |
| GO:0016021 | IEA:UniProtKB-KW | C | integral component of membrane |
| GO:0001665 | IDA:MGI | F | alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity |
| GO:0001574 | TAS:MGI | P | ganglioside biosynthetic process |
| GO:0009312 | IDA:MGI | P | oligosaccharide biosynthetic process |
| GO:0006486 | IEA:UniProtKB-UniPathway | P | protein glycosylation |
| GO:0097503 | IDA:GOC | P | sialylation |
KEGG Pathway Links
| KEGG Pathway ID | Description |
|---|---|
| mmu01100 | Metabolic pathways |
| ko00512 | Mucin type O-Glycan biosynthesis |
| mmu00512 | Mucin type O-Glycan biosynthesis |
REACTOME Pathway Links
| REACTOME Pathway ID | Description |
|---|---|
| 5893781 | Sialic acid metabolism |
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR001675 | Glycosyl transferase, family 29 |
UniProt Annotations
Entry Information
Gene Name
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1
Protein Entry
SIA7A_MOUSE
UniProt ID
Species
Mouse
Comments
| Comment Type | Description |
|---|---|
| Catalytic Activity | CMP-N-acetylneuraminate + glycano-(1->3)-(N- acetyl-alpha-D-galactosaminyl)-glycoprotein = CMP + glycano- ((2->6)-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)- glycoprotein. |
| Function | Transfers CMP-NeuAc with an alpha-2,6-linkage to the GalNAc residues of GalNAc-O-Ser/Thr, Gal-beta-1,3-GalNAc-O-Ser/Thr and NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc-O-Ser/Thr are substrates. Higher activity towards GalNAc-O-Ser/Thr. {ECO:0000269|PubMed:10788794}. |
| Pathway | Protein modification; protein glycosylation. |
| Similarity | Belongs to the glycosyltransferase 29 family. {ECO:0000305}. |
| Subcellular Location | Golgi apparatus membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}. |
| Tissue Specificity | Submaxillary gland, mammary gland, spleen and colon. |
| Web Resource | Name=Functional Glycomics Gateway - GTase; Note=ST6GalNAc I; URL="http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_mou_650"; |
Identical and Related Proteins
Unique RefSeq proteins for LMP000004 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 126116572 | RefSeq | NP_035501 | 526 | alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 |
Identical Sequences to LMP000004 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:126116572 | GenBank | AAI45374.1 | 526 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 [Mus musculus] |
| GI:126116572 | GenBank | AAI41096.1 | 526 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 [Mus musculus] |
| GI:126116572 | SwissProt | Q9QZ39.2 | 526 | RecName: Full=Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; AltName: Full=GalNAc alpha-2,6-sialyltransferase I; AltName: Full=ST6GalNAc I; Short=ST6GalNAcI; AltName: Full=Sialyltransferase 7A; Short=SIAT7-A [Mus musculus] |
Related Sequences to LMP000004 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:126116572 | EMBL | CAA72137.1 | 526 | GalNAc alpha-2,6-sialyltransferase I [Mus musculus] |
| GI:126116572 | GenBank | EDL34593.1 | 526 | mCG62614 [Mus musculus] |
| GI:126116572 | GenBank | AAI45375.1 | 515 | St6galnac1 protein [Mus musculus] |
| GI:126116572 | GenBank | AFG79805.1 | 526 | Sequence 64 from patent US 8137928 |
| GI:126116572 | GenBank | AFN90538.1 | 526 | Sequence 61 from patent US 8198045 |
| GI:126116572 | RefSeq | NP_001099329.1 | 520 | alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 precursor [Rattus norvegicus] |