Gene/Proteome Database (LMPD)

LMPD ID
LMP000007
Gene ID
20454
Species
Mus musculus (Mouse)
Gene Name
ST3 beta-galactoside alpha-2,3-sialyltransferase 5
Gene Symbol
St3gal5
Synonyms
3S-T; Siat9; [a]2
Alternate Names
lactosylceramide alpha-2,3-sialyltransferase; ST3GalV; mST3Gal V; GM3 synthase; ganglioside GM3 synthase; GM3-specific sialytransferase; CMP-NeuAc:lactosylceramide alpha-2,3-sialyltransferase; sialyltransferase 9 (CMP-NeuAc:lactosylceramide alpha-2,3-sialyltransferase)
Chromosome
6
Map Location
6|6 C3
EC Number
2.4.99.9

Proteins

lactosylceramide alpha-2,3-sialyltransferase isoform a
Refseq ID NP_001030305
Protein GI 78126157
UniProt ID O88829
mRNA ID NM_001035228
Length 414
RefSeq Status VALIDATED
MHTEAVGGAARRPQKLRSQAAAPACRAMPSEFTSAKLRSDCSRTSLQWYTRTQHKMRRPSLLIKDICKCTLVAFGVWLLYILILNYTAEECDMKRMHYVDPDRIKRAQSYAQEVLQKECRPRYAKTAMALLFEDRYSINLEPFVQKVPTASEAELKYDPPFGFRKFSSKVQSLLDMLPEHDFPEHLRAKACKRCVVVGNGGILHGLELGHALNQFDVVIRLNSAPVEGYSEHVGNKTTIRMTYPEGAPLSDVEYYANDLFVTVLFKSVDFKWLQAMVKNESLPFWVRLFFWKQVAEKVPLQPKHFRILNPVIIKETAFDILQYSEPQSRFWGHDKNIPTIGVIAVVLATHLCDEVSLAGFGYDLSQPRTPLHYFDSQCMGAMHWQVMHNVTTETKFLLKLLKEGVVEDLSGGIH
lactosylceramide alpha-2,3-sialyltransferase isoform b
Refseq ID NP_035505
Protein GI 78126169
UniProt ID O88829
mRNA ID NM_011375
Length 387
RefSeq Status VALIDATED
MPSEFTSAKLRSDCSRTSLQWYTRTQHKMRRPSLLIKDICKCTLVAFGVWLLYILILNYTAEECDMKRMHYVDPDRIKRAQSYAQEVLQKECRPRYAKTAMALLFEDRYSINLEPFVQKVPTASEAELKYDPPFGFRKFSSKVQSLLDMLPEHDFPEHLRAKACKRCVVVGNGGILHGLELGHALNQFDVVIRLNSAPVEGYSEHVGNKTTIRMTYPEGAPLSDVEYYANDLFVTVLFKSVDFKWLQAMVKNESLPFWVRLFFWKQVAEKVPLQPKHFRILNPVIIKETAFDILQYSEPQSRFWGHDKNIPTIGVIAVVLATHLCDEVSLAGFGYDLSQPRTPLHYFDSQCMGAMHWQVMHNVTTETKFLLKLLKEGVVEDLSGGIH

Gene Information

Entrez Gene ID
20454
Gene Name
ST3 beta-galactoside alpha-2,3-sialyltransferase 5
Gene Symbol
St3gal5
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0030173 IEA:InterPro C integral component of Golgi membrane
GO:0047291 ISS:UniProtKB F lactosylceramide alpha-2,3-sialyltransferase activity
GO:0006486 IEA:InterPro P protein glycosylation
GO:0097503 ISS:GOC P sialylation

KEGG Pathway Links

KEGG Pathway ID Description
mmu00604 Glycosphingolipid biosynthesis - ganglio series
mmu01100 Metabolic pathways

REACTOME Pathway Links

REACTOME Pathway ID Description
5893781 Sialic acid metabolism

Domain Information

InterPro Annotations

Accession Description
IPR001675 Glycosyl transferase, family 29
IPR012163 Sialyltransferase

UniProt Annotations

Entry Information

Gene Name
ST3 beta-galactoside alpha-2,3-sialyltransferase 5
Protein Entry
SIAT9_MOUSE
UniProt ID
O88829
Species
Mouse

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O88829-1; Sequence=Displayed; Name=2; IsoId=O88829-2; Sequence=VSP_033689;
Catalytic Activity CMP-N-acetylneuraminate + beta-D-galactosyl- (1->4)-beta-D-glucosyl-(1<->1)-ceramide = CMP + alpha-N- acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl- (1<->1)-ceramide.
Disruption Phenotype Mice are viable and fertile, and do not show any obvious abnormality apart from an increased sensitivity to insulin. {ECO:0000269|PubMed:12629211}.
Function Catalyzes the formation of ganglioside GM3 (alpha-N- acetylneuraminyl-2,3-beta-D-galactosyl-1, 4-beta-D- glucosylceramide). {ECO:0000269|PubMed:12629211}.
Sequence Caution Sequence=AAF66147.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA33491.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA76467.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB28571.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAE34763.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAA75235.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAA75236.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAC79655.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Similarity Belongs to the glycosyltransferase 29 family. {ECO:0000305}.
Subcellular Location Golgi apparatus membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Web Resource Name=Functional Glycomics Gateway - GTase; Note=ST3Gal V; URL="http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_mou_646";

Identical and Related Proteins

Unique RefSeq proteins for LMP000007 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
78126157 RefSeq NP_001030305 414 lactosylceramide alpha-2,3-sialyltransferase isoform a
78126169 RefSeq NP_035505 387 lactosylceramide alpha-2,3-sialyltransferase isoform b

Identical Sequences to LMP000007 proteins

Reference Database Accession Length Protein Name
GI:78126169 DBBJ BAB28571.1 387 unnamed protein product [Mus musculus]
GI:78126157 DBBJ BAE38355.1 414 unnamed protein product [Mus musculus]
GI:78126157 GenBank AAE80033.1 414 Sequence 4 from patent US 6280989
GI:78126169 GenBank EDK98960.1 387 ST3 beta-galactoside alpha-2,3-sialyltransferase 5, isoform CRA_b [Mus musculus]
GI:78126157 GenBank AAI38558.1 414 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 [Mus musculus]
GI:78126157 GenBank AAI38560.1 414 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 [Mus musculus]
GI:78126169 RefSeq XP_006505880.1 387 PREDICTED: lactosylceramide alpha-2,3-sialyltransferase isoform X2 [Mus musculus]
GI:78126157 SwissProt O88829.2 414 RecName: Full=Lactosylceramide alpha-2,3-sialyltransferase; AltName: Full=CMP-NeuAc:lactosylceramide alpha-2,3-sialyltransferase; AltName: Full=Ganglioside GM3 synthase; AltName: Full=ST3Gal V; Short=ST3GalV; AltName: Full=Sialyltransferase 9 [Mus musculus]

Related Sequences to LMP000007 proteins

Reference Database Accession Length Protein Name
GI:78126157 DBBJ BAB28571.1 387 unnamed protein product [Mus musculus]
GI:78126169 DBBJ BAE38355.1 414 unnamed protein product [Mus musculus]
GI:78126157 EMBL CAJ44922.1 387 unnamed protein product [Mus musculus]
GI:78126169 GenBank AAE80033.1 414 Sequence 4 from patent US 6280989
GI:78126157 GenBank EDK98960.1 387 ST3 beta-galactoside alpha-2,3-sialyltransferase 5, isoform CRA_b [Mus musculus]
GI:78126169 GenBank AAI38558.1 414 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 [Mus musculus]
GI:78126169 GenBank AAI38560.1 414 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 [Mus musculus]
GI:78126169 RefSeq NP_001030305.1 414 lactosylceramide alpha-2,3-sialyltransferase isoform a [Mus musculus]
GI:78126157 RefSeq NP_035505.2 387 lactosylceramide alpha-2,3-sialyltransferase isoform b [Mus musculus]
GI:78126157 RefSeq XP_006505879.1 505 PREDICTED: lactosylceramide alpha-2,3-sialyltransferase isoform X1 [Mus musculus]
GI:78126157 RefSeq XP_006505880.1 387 PREDICTED: lactosylceramide alpha-2,3-sialyltransferase isoform X2 [Mus musculus]
GI:78126169 SwissProt O88829.2 414 RecName: Full=Lactosylceramide alpha-2,3-sialyltransferase; AltName: Full=CMP-NeuAc:lactosylceramide alpha-2,3-sialyltransferase; AltName: Full=Ganglioside GM3 synthase; AltName: Full=ST3Gal V; Short=ST3GalV; AltName: Full=Sialyltransferase 9 [Mus musculus]