Gene/Proteome Database (LMPD)

LMPD ID
LMP000009
Gene ID
56077
Species
Mus musculus (Mouse)
Gene Name
diacylglycerol kinase, epsilon
Gene Symbol
Dgke
Synonyms
C87606; DAGK6; DGK
Alternate Names
diacylglycerol kinase epsilon; DGK-epsilon; DAG kinase epsilon; diglyceride kinase epsilon
Chromosome
11
Map Location
11 C|11
EC Number
2.7.1.107

Proteins

diacylglycerol kinase epsilon
Refseq ID NP_062378
Protein GI 9506541
UniProt ID Q9R1C6
mRNA ID NM_019505
Length 564
RefSeq Status VALIDATED
MEGDQRSGPPAQSLLPDGHLVLWTLCSVLLPVFITLWCSLQRSRRQLHRRDIFRKSKHCWRDTDLFSHPTYCCVCAQHILQGAFCDCCGLRVDEGCLKKVDKRFPCKEIMLKNDKAADAMPHHWIRGNVPLCSYCVFCRQQCGSQPKLCDYRCIWCQKTVHDECMRGSLRSEKCDFGEFRNLIIPPSYLTSINQMRKDKNTNYEGLASKFGKQWTPLIILANSRSGTNMGEGLLGEFKILLNPVQVFDVTKTPPIKALQLCTLLPYYSVRVLVCGGDGTVGWVLDAIDEMKIKGQEKYIPEVAVLPLGTGNDLSNTLGWGTGYAGEIPVAQVLRNVMEADGIKLDRWKVQVTNKGYYNLRKPKEFTMNNYFSVGPDALMALNFHAHREKAPSLFSSRILNKAVYLFYGTKDCLVQECKDLNKKIELELDGERVELPNLEGIIVLNIGYWGGGCRLWEGMGDETYPLARHDDGLLEIVGVYGSFHCAQIQVKLANPFRIGQAHTVRLTLKCSMMPMQVDGEPWAQGPCTVTITHKTHALMLYFSGEQSDDDISSPSDHEDVKEAE

Gene Information

Entrez Gene ID
56077
Gene Name
diacylglycerol kinase, epsilon
Gene Symbol
Dgke
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IEA:UniProtKB-KW C cytoplasm
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0003951 IEA:InterPro F NAD+ kinase activity
GO:0004143 IEA:UniProtKB-EC F diacylglycerol kinase activity
GO:0046872 IEA:UniProtKB-KW F metal ion binding
GO:0035556 IEA:InterPro P intracellular signal transduction
GO:0007205 IEA:InterPro P protein kinase C-activating G-protein coupled receptor signaling pathway

KEGG Pathway Links

KEGG Pathway ID Description
mmu00561 Glycerolipid metabolism
mmu00564 Glycerophospholipid metabolism
mmu01100 Metabolic pathways
mmu04070 Phosphatidylinositol signaling system

Domain Information

InterPro Annotations

Accession Description
IPR016064 ATP-NAD kinase-like domain
IPR000756 Diacylglycerol kinase, accessory domain
IPR001206 Diacylglycerol kinase, catalytic domain
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain

UniProt Annotations

Entry Information

Gene Name
diacylglycerol kinase, epsilon
Protein Entry
DGKE_MOUSE
UniProt ID
Q9R1C6
Species
Mouse

Comments

Comment Type Description
Catalytic Activity ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2- diacyl-sn-glycerol 3-phosphate.
Function Highly selective for arachidonate-containing species of diacylglycerol (DAG). May terminate signals transmitted through arachidonoyl-DAG or may contribute to the synthesis of phospholipids with defined fatty acid composition (By similarity). {ECO:0000250}.
Similarity Belongs to the eukaryotic diacylglycerol kinase family. {ECO:0000305}.
Similarity Contains 1 DAGKc domain. {ECO:0000255|PROSITE- ProRule:PRU00783}.
Similarity Contains 2 phorbol-ester/DAG-type zinc fingers. {ECO:0000255|PROSITE-ProRule:PRU00226}.
Subcellular Location Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}.
Tissue Specificity Expressed in platelets. {ECO:0000269|PubMed:23542698}.

Identical and Related Proteins

Unique RefSeq proteins for LMP000009 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
9506541 RefSeq NP_062378 564 diacylglycerol kinase epsilon

Identical Sequences to LMP000009 proteins

Reference Database Accession Length Protein Name
GI:9506541 GenBank AAD45665.1 564 diacylglycerol kinase epsilon [Mus musculus]
GI:9506541 GenBank AAI40302.1 564 Diacylglycerol kinase, epsilon, partial [synthetic construct]
GI:9506541 GenBank AAI48726.1 564 Diacylglycerol kinase, epsilon [synthetic construct]
GI:9506541 SwissProt Q9R1C6.1 564 RecName: Full=Diacylglycerol kinase epsilon; Short=DAG kinase epsilon; AltName: Full=Diglyceride kinase epsilon; Short=DGK-epsilon [Mus musculus]

Related Sequences to LMP000009 proteins

Reference Database Accession Length Protein Name
GI:9506541 GenBank EDL15870.1 571 diacylglycerol kinase, epsilon, partial [Mus musculus]
GI:9506541 RefSeq XP_005350574.1 565 PREDICTED: diacylglycerol kinase epsilon [Microtus ochrogaster]
GI:9506541 RefSeq XP_006247132.1 567 PREDICTED: diacylglycerol kinase epsilon isoform X1 [Rattus norvegicus]
GI:9506541 RefSeq XP_006972083.1 565 PREDICTED: diacylglycerol kinase epsilon [Peromyscus maniculatus bairdii]
GI:9506541 RefSeq XP_007622288.1 565 PREDICTED: diacylglycerol kinase epsilon [Cricetulus griseus]
GI:9506541 RefSeq XP_007632395.1 565 PREDICTED: diacylglycerol kinase epsilon [Cricetulus griseus]