Gene/Proteome Database (LMPD)

LMPD ID
LMP000012
Gene ID
107650
Species
Mus musculus (Mouse)
Gene Name
phosphatidylinositol 4-kinase, catalytic, beta polypeptide
Gene Symbol
Pi4kb
Synonyms
ESTM41; PI4K-beta; PI4Kbeta; Pik4cb
Chromosome
3
Map Location
3 F2.1|3

Proteins

phosphatidylinositol 4-kinase beta isoform 1
Refseq ID NP_001280644
Protein GI 656985047
UniProt ID Q8BKC8
mRNA ID NM_001293715
Length 816
RefSeq Status VALIDATED
MGDMVVEPATLKPTSEPTPSPSGNNGGSLLSVITEGVGELSVIDPEVAQKACQEVLEKVKLLHGGVAISSKGTPLELVNGDGVDNEIRCLDDPPAQIREEEDEMGAGVASGTAKGARRRRQNNSAKQSWLLRLFESKLFDISMAISYLYNSKEPGVQAYIGNRLFYFRNEDVDFYLPQLLNMYIHMDEDVGDAIKPYIVHRCRQSINFSLQCALLLGAYSSDMHISTQRHSRGTKLRKLILSDELKPAHRKRELPTLSPAPDTGLSPSKRTHQRSKSDATASISLSSNLKRTASNPKVENEDEELSSSTESIDNSFSSPVRLAPEREFIKSLMAIGKRLATLPTKEQKTQRLISELSLLNHKLPARVWLPTAGFDHHVVRVPHTQAVVLNSKDKAPYLIYVEVLECENFDTTSVPARIPENRIRSTRSVENLPECGITHEQRAGSFSTVPNYDNDDEAWSVDDIGELQVELPEVHTNSCDNISQFSVDSITSQESKEPVFIAAGDIRRRLSEQLAHTPTAFKRDPEDPSAVALKEPWQEKVRRIREGSPYGHLPNWRLLSVIVKCGDDLRQELLAFQVLKQLQSIWEQERVPLWIKPYKILVISADSGMIEPVVNAVSIHQVKKQSQLSLLDYFLQEHGSYTTEAFLSAQRNFVQSCAGYCLVCYLLQVKDRHNGNILLDAEGHIIHIDFGFILSSSPRNLGFETSAFKLTTEFVDVMGGLNGDMFNYYKMLMLQGLIAARKHMDKVVQIVEIMQQGSQLPCFHGSSTIRNLKERFHMSMTEEQLQLLVEQMVDGSMRSITTKLYDGFQYLTNGIM
phosphatidylinositol 4-kinase beta isoform 2
Refseq ID NP_780565
Protein GI 256000773
UniProt ID Q8BKC8
mRNA ID NM_175356
Length 801
RefSeq Status VALIDATED
MGDMVVEPATLKPTSEPTPSPSGNNGGSLLSVITEGVGELSVIDPEVAQKACQEVLEKVKLLHGGVAISSKGTPLELVNGDGVDNEIRCLDDPPAQIREEEDEMGAGVASGTAKGARRRRQNNSAKQSWLLRLFESKLFDISMAISYLYNSKEPGVQAYIGNRLFYFRNEDVDFYLPQLLNMYIHMDEDVGDAIKPYIVHRCRQSINFSLQCALLLGAYSSDMHISTQRHSRGTKLRKLILSDELKPAHRKRELPTLSPAPDTGLSPSKRTHQRSKSDATASISLSSNLKRTASNPKVENEDEPVRLAPEREFIKSLMAIGKRLATLPTKEQKTQRLISELSLLNHKLPARVWLPTAGFDHHVVRVPHTQAVVLNSKDKAPYLIYVEVLECENFDTTSVPARIPENRIRSTRSVENLPECGITHEQRAGSFSTVPNYDNDDEAWSVDDIGELQVELPEVHTNSCDNISQFSVDSITSQESKEPVFIAAGDIRRRLSEQLAHTPTAFKRDPEDPSAVALKEPWQEKVRRIREGSPYGHLPNWRLLSVIVKCGDDLRQELLAFQVLKQLQSIWEQERVPLWIKPYKILVISADSGMIEPVVNAVSIHQVKKQSQLSLLDYFLQEHGSYTTEAFLSAQRNFVQSCAGYCLVCYLLQVKDRHNGNILLDAEGHIIHIDFGFILSSSPRNLGFETSAFKLTTEFVDVMGGLNGDMFNYYKMLMLQGLIAARKHMDKVVQIVEIMQQGSQLPCFHGSSTIRNLKERFHMSMTEEQLQLLVEQMVDGSMRSITTKLYDGFQYLTNGIM
phosphatidylinositol 4-kinase beta isoform 3
Refseq ID NP_001280645
Protein GI 656985050
UniProt ID Q8BKC8
mRNA ID NM_001293716
Length 484
RefSeq Status VALIDATED
MAIGKRLATLPTKEQKTQRLISELSLLNHKLPARVWLPTAGFDHHVVRVPHTQAVVLNSKDKAPYLIYVEVLECENFDTTSVPARIPENRIRSTRSVENLPECGITHEQRAGSFSTVPNYDNDDEAWSVDDIGELQVELPEVHTNSCDNISQFSVDSITSQESKEPVFIAAGDIRRRLSEQLAHTPTAFKRDPEDPSAVALKEPWQEKVRRIREGSPYGHLPNWRLLSVIVKCGDDLRQELLAFQVLKQLQSIWEQERVPLWIKPYKILVISADSGMIEPVVNAVSIHQVKKQSQLSLLDYFLQEHGSYTTEAFLSAQRNFVQSCAGYCLVCYLLQVKDRHNGNILLDAEGHIIHIDFGFILSSSPRNLGFETSAFKLTTEFVDVMGGLNGDMFNYYKMLMLQGLIAARKHMDKVVQIVEIMQQGSQLPCFHGSSTIRNLKERFHMSMTEEQLQLLVEQMVDGSMRSITTKLYDGFQYLTNGIM

Gene Information

Entrez Gene ID
107650
Gene Name
phosphatidylinositol 4-kinase, catalytic, beta polypeptide
Gene Symbol
Pi4kb
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005794 IEA:UniProtKB-KW C Golgi apparatus
GO:0005737 IBA:RefGenome C cytoplasm
GO:0005829 IEA:Ensembl C cytosol
GO:0005783 IEA:UniProtKB-KW C endoplasmic reticulum
GO:0005741 IEA:UniProtKB-KW C mitochondrial outer membrane
GO:0005886 IEA:Ensembl C plasma membrane
GO:0004430 IBA:RefGenome F 1-phosphatidylinositol 4-kinase activity
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0006661 IEA:InterPro P phosphatidylinositol biosynthetic process
GO:0048015 IEA:InterPro P phosphatidylinositol-mediated signaling

KEGG Pathway Links

KEGG Pathway ID Description
ko00562 Inositol phosphate metabolism
mmu00562 Inositol phosphate metabolism
M00130 Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
mmu01100 Metabolic pathways
ko04070 Phosphatidylinositol signaling system
mmu04070 Phosphatidylinositol signaling system

BIOCYC Pathway Links

BIOCYC Pathway ID Description
PWY-6352 3-phosphoinositide biosynthesis
PWY-6351 D-myo-inositol (1,4,5)-trisphosphate biosynthesis
PWY3DJ-219 PIP metabolism

REACTOME Pathway Links

REACTOME Pathway ID Description
5892760 Metabolism
5892799 Metabolism of lipids and lipoproteins
5893988 PI Metabolism
5892984 Phospholipid metabolism
5894012 Synthesis of PIPs at the Golgi membrane

Domain Information

InterPro Annotations

Accession Description
IPR000403 Phosphatidylinositol 3-/4-kinase, catalytic domain
IPR018936 Phosphatidylinositol 3/4-kinase, conserved site
IPR027003 Phosphatidylinositol 4-kinase
IPR015433 Phosphatidylinositol Kinase
IPR001263 Phosphoinositide 3-kinase, accessory (PIK) domain
IPR011009 Protein kinase-like domain

UniProt Annotations

Entry Information

Gene Name
phosphatidylinositol 4-kinase, catalytic, beta polypeptide
Protein Entry
Q8BKC8_MOUSE
UniProt ID
Q8BKC8
Species
Mouse

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8BKC8-1; Sequence=Displayed; Name=2; IsoId=Q8BKC8-2; Sequence=VSP_037135; Note=Contains a phosphoserine at position 294.; Name=3; IsoId=Q8BKC8-3; Sequence=VSP_037134;
Catalytic Activity ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate. {ECO:0000250|UniProtKB:Q9UBF8}.
Enzyme Regulation Inhibited by wortmannin. Increased kinase activity upon interaction with NCS1/FREQ. {ECO:0000250}.
Function Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol- 1,4,5,-trisphosphate (PIP). May regulate Golgi disintegration/reorganization during mitosis, possibly via its phosphorylation (By similarity). Involved in Golgi-to-plasma membrane trafficking (By similarity). {ECO:0000250}.
Similarity Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily. {ECO:0000305}.
Similarity Contains 1 PI3K/PI4K domain. {ECO:0000255|PROSITE- ProRule:PRU00269}.
Similarity Contains 1 PIK helical domain. {ECO:0000255|PROSITE- ProRule:PRU00878}.
Subcellular Location Endomembrane system {ECO:0000250}. Mitochondrion outer membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Rough endoplasmic reticulum membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Golgi apparatus {ECO:0000250}. Note=Found in the outer membrane of mitochondria and membranes of the rough endoplasmic reticulum. Recruited to the Golgi complex by the small GTPase ARF to stimulate the synthesis of phosphatidylinositol 4,5-bisphosphate (PIP2) on the Golgi complex (By similarity). {ECO:0000250}.
Subunit Interacts with NCS1/FREQ in a calcium-independent manner. Interacts with CALN1/CABP8 and CALN2/CABP7; in a calcium-dependent manner. This binding competes with NCS1/FREQ binding. Interacts with ARF1 and ARF3. {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP000012 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
656985047 RefSeq NP_001280644 816 phosphatidylinositol 4-kinase beta isoform 1
256000773 RefSeq NP_780565 801 phosphatidylinositol 4-kinase beta isoform 2
656985050 RefSeq NP_001280645 484 phosphatidylinositol 4-kinase beta isoform 3

Identical Sequences to LMP000012 proteins

Reference Database Accession Length Protein Name
GI:256000773 DBBJ BAC26222.1 801 unnamed protein product [Mus musculus]
GI:256000773 DBBJ BAE34263.1 801 unnamed protein product [Mus musculus]
GI:256000773 GenBank AAH79846.1 801 Phosphatidylinositol 4-kinase, catalytic, beta polypeptide [Mus musculus]
GI:656985047 GenBank AAI13177.1 816 Pik4cb protein [Mus musculus]
GI:656985050 GenBank AAI13782.1 484 Pik4cb protein [Mus musculus]
GI:656985047 GenBank ABK42319.1 816 phosphoinositide 4-kinase type III beta [synthetic construct]
GI:656985047 GenBank EDL38762.1 816 phosphatidylinositol 4-kinase, catalytic, beta polypeptide, isoform CRA_a [Mus musculus]
GI:256000773 GenBank AAI38459.1 801 Phosphatidylinositol 4-kinase, catalytic, beta polypeptide [Mus musculus]
GI:256000773 GenBank AAI38458.1 801 Phosphatidylinositol 4-kinase, catalytic, beta polypeptide [Mus musculus]
GI:656985050 RefSeq XP_005357063.1 484 PREDICTED: phosphatidylinositol 4-kinase beta isoform X3 [Microtus ochrogaster]
GI:656985050 RefSeq XP_006168479.1 484 PREDICTED: phosphatidylinositol 4-kinase beta isoform X2 [Tupaia chinensis]
GI:656985047 SwissProt Q8BKC8.2 816 RecName: Full=Phosphatidylinositol 4-kinase beta; Short=PI4K-beta; Short=PI4Kbeta; Short=PtdIns 4-kinase beta [Mus musculus]

Related Sequences to LMP000012 proteins

Reference Database Accession Length Protein Name
GI:656985050 DBBJ BAC26222.1 801 unnamed protein product [Mus musculus]
GI:256000773 DBBJ BAC35448.1 801 unnamed protein product [Mus musculus]
GI:656985050 DBBJ BAC35448.1 801 unnamed protein product [Mus musculus]
GI:256000773 DBBJ BAE42812.1 801 unnamed protein product [Mus musculus]
GI:656985050 GenBank AAH79846.1 801 Phosphatidylinositol 4-kinase, catalytic, beta polypeptide [Mus musculus]
GI:256000773 GenBank ABK42319.1 816 phosphoinositide 4-kinase type III beta [synthetic construct]
GI:256000773 GenBank EDL38762.1 816 phosphatidylinositol 4-kinase, catalytic, beta polypeptide, isoform CRA_a [Mus musculus]
GI:256000773 GenBank EDL38763.1 831 phosphatidylinositol 4-kinase, catalytic, beta polypeptide, isoform CRA_b, partial [Mus musculus]
GI:656985047 GenBank EDL85763.1 816 phosphatidylinositol 4-kinase, catalytic, beta polypeptide, isoform CRA_a [Rattus norvegicus]
GI:656985047 GenBank EDL85764.1 816 phosphatidylinositol 4-kinase, catalytic, beta polypeptide, isoform CRA_a [Rattus norvegicus]
GI:656985050 GenBank AAI38459.1 801 Phosphatidylinositol 4-kinase, catalytic, beta polypeptide [Mus musculus]
GI:656985050 GenBank AAI38458.1 801 Phosphatidylinositol 4-kinase, catalytic, beta polypeptide [Mus musculus]
GI:656985050 RefSeq NP_780565.2 801 phosphatidylinositol 4-kinase beta isoform 2 [Mus musculus]
GI:656985047 RefSeq XP_005084350.1 828 PREDICTED: phosphatidylinositol 4-kinase beta isoform X1 [Mesocricetus auratus]
GI:656985047 RefSeq XP_005084351.1 816 PREDICTED: phosphatidylinositol 4-kinase beta isoform X2 [Mesocricetus auratus]
GI:656985047 RefSeq XP_006994851.1 816 PREDICTED: phosphatidylinositol 4-kinase beta isoform X2 [Peromyscus maniculatus bairdii]
GI:256000773 RefSeq NP_001280644.1 816 phosphatidylinositol 4-kinase beta isoform 1 [Mus musculus]
GI:656985047 SwissProt O08561.1 816 RecName: Full=Phosphatidylinositol 4-kinase beta; Short=PI4K-beta; Short=PI4Kbeta; Short=PtdIns 4-kinase beta [Rattus norvegicus]